発表論文

TOP 発表論文 Papers 2021

研究成果

Papers 2021

  1. Yukawa, T., Bamba, T., Guirimand, G., Matsuda, M., Hasunuma, T., Kondo, A. (2021/01) Optimization of 1,2,4-butanetriol production from xylose in Saccharomyces cerevisiae by metabolic engineering of NADH/NADPH balance, Biotechnology and Bioengineering, 118(1), 175-185

  2. Takenaka, M., Yoshida, T., Hori, Y., Bamba, T., Mochizuki, M., Vavricka, CJ., Hattori, T., Hayakawa, Y., Hasunuma, T., Kondo, A. (2021/01) An ion-pair free LC-MS/MS method for quantitative metabolite profiling of microbial bioproduction systems, Talanta, 222, 121625

  3. Nakashima, A., Sasaki, K., Sasaki, D., Yasuda, K., Suzuki, K., Kondo, A. (2021/01) The alga Euglena gracilis stimulates Faecalibacterium in the gut and contributes to increased defecation, Scientific Reports, 11, 1074

  4. Sasaki, K., Sasaki, D., Tsuge, Y., Morita, M., Kondo, A. (2021/01) Enhanced methane production from cellulose using a two-stage process involving a bioelectrochemical system and a fixed film reactor, Biotechnology for Biofuels, 14: 7

  5. Nag, A., Ali, MA., Kawaguchi, H., Saito, S., Kawasaki, Y., Miyazaki, S., Kawamoto, H., Nugroho Adi, DT., Yoshihara, K., Masuo, S., Katsuyama, Y., Kondo, A., Ogino, C., Takaya, N., Kaneko, T., Ohnishi, Y. (2021/01) Ultrahigh thermoresistant lightweight bioplastics developed from fermentation products of cellulosic feedstock, Advanced Sustainable Systems, 5(1), 2000193

  6. Nishida, K., Kondo, A. (2021/01) CRISPR-derived genome editing technologies for metabolic engineering, Metabolic Engineering, 63, 141-147

  7. Nakamura, Y., Asama, R., Tabata, T., Morita, K., Maruyama, T., Kondo, A., Ishii, J. (2021/02) Comparative analyses of site-directed mutagenesis of human melatonin MTNR1A and MTNR1B receptors using a yeast fluorescent biosensor, Biotechnology and Bioengineering, 118(2), 863-876

  8. Sasaki, K., Sasaki, D., Sasaki, K., Nishidono, Y, Yamamori, A., Tanaka, K., Kondo, A. (2021/02) Growth stimulation of Bifidobacterium from human colon using daikenchuto in an in vitro model of human intestinal microbiota, Scientific Reports, 11: 4580

  9. Hashimoto, S., Wake, T., Nakamura, H., Minamiyama, M., Araki-Nakamura, S., Ohmae-Shinohara, K., Koketsu, E., Okamura, S., Miura, K., Kawaguchi, H., Kasuga, S., Sazuka, T. (2021/02) The dominance model for heterosis explains culm length genetics in a hybrid sorghum variety, Scietific Reports, 11(1): 4532

  10. Nonaka, D., Fujiwara, R., Hirata, Y., Tanaka, T., Kondo, A. (2021/02) Metabolic engineering of 1,2-propanediol production from cellobiose using beta-glucosidase-expressing E. coli, Bioresource Technology, 329, 124858

  11. Morita, K., Nishimura, Y.,Nakamura, S., Arai, Y., Numako, C., Sato, K., Nakayama, M., Akasaka, H., Sasaki, R., Ogino, C., Kondo, A. (2021/02) Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells, Colloids and Surfaces B: Biointerfaces, 198: 111451

  12. Shibata, N., Kakeshita, H., Igarashi, K., Takimura, Y., Shida, Y., Ogasawara, W., Koda, T., Hasunuma, T., Kondo, A. (2021/02) Disruption of alpha-tubulin releases carbon catabolite repression and enhances enzyme production in Trichoderma reesei even in the presence of glucose, Biotechnology for Biofuels, 14(1): 39

  13. Rachmadona, N., Quayson, E., Amoah, J., Alfaro-Sayes, DA., Hama, S., Aznury, M., Kondo, A., Ogino, C. (2021/02) Utilizing palm oil mill effluent (POME) for the immobilization of Aspergillus oryzae whole-cell lipase strains for biodiesel synthesis, Biofuels, Bioproducts & Biorefining, 15: 804-814

  14. Tominaga, M., Nozaki, K., Umeno, D., Ishii, J., Kondo, A. (2021/03) Robust and flexible platform for directed evolution of yeast genetic switches, Nature Communications, 12: 1846

  15. Kanamoto, A., Kato, Y., Yoshida, E., Hasunuma, T., Kondo, A. (2021/03) Development of a method for fucoxanthin production using the haptophyte marine microalga Pavlova sp. OPMS 30543, Marine Biotechnology, 23, 331-341 (4月号表紙採用)

  16. Mao, N., Aggarwal, N., Poh, CL., Cho, BK., Kondo, A., Liu, C., Yew, WS., Chang, MW. (2021/03) Future trends in synthetic biology in Asia, Advanced Genetics, 2(1), e10038

  17. Hoshi, N., Inoue, J., Sasaki, D., Sasaki, K. (2021/04) The Kobe University Human Intestinal Microbiota Model for gut intervention studies (mini review), Applied Microbiology and Biotechnology, 105(7), 2625-2632

  18. Mori, Y., Noda, S., Shirai, T., Kondo, A. (2021/04) Direct 1,3-butadiene biosynthesis in Escherichia coli via a tailored ferulic acid decarboxylase mutant, Nature Communications, 12: 2195

  19. Kato, Y., Oyama, T., Inokuma, K., Vavricka, CJ., Matsuda, M., Hidese, R., Satoh, K., Oono, Y., Chang, JS., Hasunuma, T., Kondo, A. (2021/04) Enhancing carbohydrate repartitioning into lipid and carotenoid by disruption of microalgae starch debranching enzyme, Communications Biology, 4: 450

  20. Yuan, S., Kawasaki, S., Abdellatif, I.MY., Nishida, K., Kondo, A., Ariizumi, T., Ezura, H., Miura, K. (2021/04) Efficient base editing in tomato using a highly expressed transient system, Plant Cell Reports, 40(4): 667-676

  21. Shoji, S., Yamaji, T., Makino, H., Ishii, J., Kondo, A. (2021/05) Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide, Metabolic Engineering, 65, 167-177

  22. Guirimand, G., Kulagina, N., Papon, N., Hasunuma, T., Courdavault, V. (2021/05) Innovative tools and strategies for optimizing yeast cell factories, Trends in Biotechnology, 39(5), 488-504

  23. Ogawa, S., Shimidzu, H., Fukuda, K., Tsunekawa, N., Hirano, T., Sato, F., Yura, K., Hasunuma, T., Ochi, K., Yamamoto, M., Sakamoto, W., Hashimoto, K., Ogata, H., Kanao, T., Nemoto, M., Inagaki, K., Tamura, T. (2021/05) Multiple mutations in RNA polymerase β-subunit gene rpoB in Streptomyces incarnatus NRRL8089 enhance production of antiviral antibiotic sinefungin: Modeling rif cluster region by density functional theory, Bioscience, Biotechnology, and Biochemistry, 85(5), 1275-1282

  24. Iijima, H., Watanabe, A., Sukigara, H., Iwazumi, K., Shirai, T., Kondo, A., Osanai, T. (2021/05) Four-carbon dicarboxylic acid production through the reductive branch of the open cyanobacterial tricarboxylic acid cycle in Synechocystis sp. PCC 6803, Metabolic Engineering, 65, 88-98

  25. Kaffashsaie, E., Yousefi, H., Nishino, T., Matsumoto, T., Mashkour, M., Madhoushi, M., Kawaguchi, H. (2021/06) Direct conversion of raw wood to TEMPO-oxidized cellulose nanofibers, Carbohydrate polymers, 262(15): 117938

  26. Wolf, S, Becker, J., Tsuge, Y., Kawaguchi, H., Kondo, A., Marienhagen, J., Bott, M., Wendisch, V.F., Wittmann, C. (Review) (2021/06) Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being, Essays in Biochemistry, 65(2): 197–212

  27. Isogai, S., Okahashi, N., Asama, R., Nakamura, T., Hasunuma, T., Matsuda, F., Ishii, J., Kondo, A. (2021/06) Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases, Metabolic Engineering Communications, 12, e00169

  28. Xu, M., Harmon, J., Yuan, D., Yan, S., Lei, C., Hiramatsu, K., Zhou, Y., Loo, MH., Hasunuma, T., Isozaki, A., Goda, K. (2021/06) Morphological Indicator for Directed Evolution of Euglena gracilis with a High Heavy Metal Removal Efficiency, Environmental Science and Technology, 55(12): 7880-7889

  29. Sasaki, K., Mori, T., Hoshi, N., Sasaki, D., Inoue, J., Shinkura, R., Kondo, A. (2021/07) W27 IgA suppresses growth of Escherichia in an in vitro model of the human intestinal microbiota, Scientific Reports, 11(1): 14627

  30. Chen, JH., Kato, Y., Matsuda, M., Chen, CY., Nagarajan, D., Hasunuma, T., Kondo, A., Chang, JS. (2021/08) Lutein production with Chlorella sorokiniana MB-1-M12 using novel two-stage cultivation strategies - metabolic analysis and process improvement, Bioresource Technology, 334, 125200

  31. Sakuragawa, T., Wakai, S., Zhang, S., Kawaguchi, H., Ogino, C., Kondo, A. (2021/08) Accelerated glucose metabolism in hyphae-dispersed Aspergillus oryzae is suitable for biological production, Journal of Bioscience and Bioengineering, 132(2), 140-147

  32. Inokuma, K., Kitada, Y., Bamba, T., Kobayashi, Y., Yukawa, T., den Haan, R., van Zyl, W. H., Kondo, A., Hasunuma, T. (2021/08) Improving the functionality of surface-engineered yeast cells by altering the cell wall morphology of the host strain, Applied Microbiology and Biotechnology, 105(14-15): 5895-5904

  33. Kee, PE., Yim, HS., Kondo, A., Lan, J. C-W., Ng, HS. (2021/08) Evaluation of aqueous biphasic electrophoresis system based on halide-free ionic liquids for direct recovery of Keratinase, Marine Drugs, 19(8): 463

  34. Kee, PE., Yim, HS., Kondo, A., Wei Won, SY., Chen, P-T., Lan, J. C-W., Ng, HS. (2021/08) Incorporation of electric fields to ionic liquids-based aqueous biphasic system for enhanced recovery of extracellular Kytococcus sedentarius TWHKC01 keratinase, Journal of the Taiwan Institute of Chemical Engineers, 125, 35-40

  35. Noda, S., Mori, Y., Fujiwara, R., Shirai, T., Tanaka, T., Kondo, A. (2021/09) Reprogramming Escherichia coli pyruvate-forming reaction towards chorismate derivatives production, Metabolic Engineering, 67, 1-10

  36. Cunha, JT. Gomes, DG. Romaní, A., Inokuma, K., Hasunuma, T., Kondo, A., Domingues, L. (2021/09) Cell surface engineering of Saccharomyces cerevisiae for simultaneous valorization of corn cob and cheese whey via ethanol production, Energy Conversion and Management, 243, 114359

  37. Yuzawa, T., Shirai, T., Orishimo, R., Kawai, K., Kondo, A., Hirasawa, T. (2021/10) 13C-metabolic flux analysis in glycerol-assimilating strains of Saccharomyces cerevisiae, The Journal of General and Applied Microbiology 67(4): 142-149

  38. Vikromvarasiri, N., Shirai., Kondo, A. (2021/10) Metabolic engineering design to enhance (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis based on flux balance analysis, Microbial Cell Factory, 20(1): 196

  39. Zhang, C., Hasunuma, T., Lam, SS., Kondo, A., Ho, SH. (2021/11) Salinity-induced microalgal-based mariculture wastewater treatment combined with biodiesel production, Bioresource Technology, 340, 125638

  40. Yoshida, E., Kojima, M., Suzuki, M., Matsuda, F., Shimbo, K., Onuki, A., Nishio, Y., Usuda, Y., Kondo, A., Ishii, J. (2021/11) Increased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis, Scientific Reports, 11(1): 22126

  41. Yoshida, N., Yamashita, T., Osone, T., Hosooka, T., Shinohara, M., Kitahama, S., Sasaki, K., Sasaki, D., Yoneshiro, T., Suzuki, T., Emoto, T., Saito, Y., Ozawa, G., Hirota, Y., Kitaura, Y., Shimomura, Y., Okamatsu-Ogura, Y., Saito, M., Kondo, A., Kajimura, S., Inagaki, T., Ogawa, W., Yamada, T., Hirata, K. (2021/11) Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity, iScience, 24(11): 103342

  42. Kobayashi, Y., Inokuma, K., Matsuda, M., Kondo, A., Hasunuma, T. (2021/12) Resveratrol production from several types of saccharide sources by a recombinant Scheffersomyces stipitis strain, Metabolic Engineering Communications, 13: e00188

  43. Inabe, K., Miichi, A., Matsuda, M., Yoshida, T., Kato, Y., Hidese, R., Kondo, A., Hasunuma, T. (2021/12) Nitrogen availability affects the metabolic profile in Cyanobacteria, Metabolites, 11, 867

  44. Oyama, T., Kato, Y., Satoh, K., Oono, Y., Matsuda, M., Hasunuma, T., Kondo, A. (2021/12) Development of mutant microalgae that accumulate lipids under nitrate-replete conditions, Algal Research, 60, 102544

  45. Kawaguchi, H., Hasunuma, T., Ohnishi, Y., Sazuka, T., Kondo, A., Ogino, C. (2021/12) Enhanced production of γ-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation, Microbial Cell Factories, 20: 228

  46. Katsurada, K., Tominaga, M., Kaishima, M., Kato, H., Matsuno, T., Ogino, C., Kondo, A., Ishii, J., Takayama, K. (2021/12) Constitutive cell surface expression of ZZ domain for the easy preparation of yeast-based immunosorbents, The Journal of General and Applied Microbiology, 67(6), 265-268

総説・解説

  1. Weijie Zhao (panelist: George Church, Jum Collins, Paul Freemont, Jay Keasling, Akihiko Kondo, Sang Yup Lee, Christina Smolke, Claudia Vickers, Xian-En Zhang, Guoping Zhao, Chenli Liu(Chair)), A forum on synthetic biology: meet the great challenges with new technology, National Science Review, 8(1), nwaa252 (2021/01)

  2. 石井純, 新型コロナで変わる時代の実験自動化・遠隔化 「微生物での発酵生産と実験の自動化」, 羊土社，第39巻，第1号，8-12, (2021/01)

  3. 佐々木建吾, 佐々木大介, in vitroヒト大腸細菌叢モデルによる構造の異なる食物繊維の発酵性評価法, 生化学，第93巻，第1号，167-172, (2021/02)

  4. 松本圭司, 発酵で作るバイオプラスチック, 生物工学会誌, 99(4), 188-192 (2021/04)

  5. 猪熊健太郎, ヒアルロン酸バイオ生産技術の歩み, 生物工学会誌, 99(4), 198 (2021/04)

  6. 中村泰之, 近藤昭彦, 石井純, 酵母シグナル伝達経路を利用したリガンド検出システムの開発とメタボライトセンサへの応用, 細胞, 53(5), 37-40 (2021/05)

  7. 佐々木建吾, 佐々木大介, 近藤昭彦, 電気化学的前処理／通電式担体充填による2段発酵を廃水・廃棄物処理へ適用, 化学と生物, 59(12), 247-253 (2021/05)

  8. 中村泰之, 近藤昭彦, 石井純, 酵母細胞を用いたG蛋白質共役型受容体リガンド検出システムの開発とメタボライトセンサへの応用, アグリバイオ, vol.5, No.7, 58-63 (2021/07)

  9. 蓮沼誠久, 新井宗仁, 特集 藻類バイオマス利用のための新しい生物工学, 生物工学会誌, 99(8), 403 (2021/08)

  10. 加藤悠一, 秀瀬涼太, 蓮沼誠久, 特集 藻類バイオマス利用のための新しい生物工学（後半）, 光合成メタボロミクスの物質生産への応用, 生物工学会誌, 99(9), 456-460 (2021/09)

  11. 林勇樹, 工藤恒, 新井宗仁, ラン藻が持つアルカン合成関連酵素の高活性化, 生物工学会誌, 99(9), 469-472 (2021/09)

  12. 中村泰之, 近藤昭彦, 石井純, 酵母細胞を用いたG蛋白質共役型受容体リガンドスクリーニングシステムの開発とメタボライトセンサへの応用, Precision Medicine, vol.4, No.13, 60-65 (2021/12)

  13. 岡橋伸幸, 磯貝章太, 石井純, 松田史生, 出芽酵母代謝工学株が生産するファイトケミカルの高分解能質量分析による構造確認 –プレニルナリンゲニンの分析–, 島津製作所 Application Notes, No.72 (2021/12)

著書

  1. 大西美輪, 光延仁志, 西田敬二, 最新のゲノム編集技術と用途展開, 第2編：ゲノム編集ツールの開発動向, 第5章 DNA二重鎖切断を伴なわない塩基編集技術, シーエムシー出版, 43-50 (2021/02)

  2. 西田敬二, 近藤昭彦, 最新のゲノム編集技術と用途展開, 第3編：微生物への応用と用途展開, 第9章 バクテリアでのゲノム編集の有用性, シーエムシー出版, 79-83 (2021/02)

  3. 蓮沼誠久, メタボロミクス 実践ガイド, 応用・展望編 Ⅰ. 応用研究　代謝工学分野へのメタボロミクスの応用, 羊土社, 302-304 (2021/04)

  4. Kato, Y., Hasunuma, T. Metabolic Engineering for Carotenoid Production Using Eukaryotic Microalgae and Prokaryotic Cyanobacteria, Carotenoids: Biosynthetic and Biofunctional Approaches, Springer, 121-135 (2021/04)

  5. 蓮沼誠久, バイオリアクターのスケールアップと物質生産事例集, 第11章 スマートセルの動向と効率的創製に向けたAI活用, 第1節 国内におけるスマートセルの動向, 481-489, 技術情報協会 (2021/04)

  6. 蓮沼誠久, 醸造の辞典, 第2章 醸造の科学, 最近の育種技術, 朝倉書店, 150-151 (2021/06)