研究業績

シングルセル解析

Thayaparan D, Emoto T, et al. Atherosclerotic plaque macrophages drive abdominal aortic aneurysm formation. Nat Immunol. doi:10.1038/s41590-025-02132-8.

Suzuki Y, Emoto T, Sato S, et al. Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation. Commun Biol. 2024; 7: 1601.

Inoue T, Emoto T, Yamanaka K, et al. Intense impact of IL-1β expressing inflammatory macrophages in acute aortic dissection. Sci Rep. 2024; 14: 14893.

Takeda S, Emoto T, Yamashita T, et al. Single-Cell RNA Sequencing reveals an Immune Landscape of CD4+ T cells in Coronary Culprit Plaques with Acute Coronary Syndrome in humans. Arterioscler Thromb Vasc Biol. 2024; 44: 1135-1143.

Emoto T, Yamamoto H, Yamashita T, et al. Single Cell RNA Seq Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome. Circulation. 2022; 145: 1434-36.

腸内細菌叢関連研究

Nakashima H, Shinohara R, Emoto T, et al. Phocaeicola dorei and Phocaeicola vulgatus protect against atherosclerosis by regulating gut immunity. J Atheroscler Thromb. 2025. in press.

Shimizu H, Miyamoto J, Hisa K, et al. Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides. Nat Commun. 2025; 16: 1145.

Ito E, Ohki T, Toya N, et al. Metagenomic Analysis of Gut Microbiota for Abdominal Aortic Aneurysm. Ann Vasc Dis. 2025; 18: 24-00105.

Watanabe S, Yoshida N, Baba K, et al. Gut microbial stability in older Japanese populations: insights from the Mykinso cohort. Biosci Microbiota Food Health. 2024; 43: 64-72.

Shinohara R, Nakashima H, Emoto T, et al. Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice. Hypertension. 2022; 79: 2821-2829.

Saito Y, Yamashita T, Yoshida N, et al. Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils. Atherosclerosis. 2022; 358: 1-11.

Otoshi T, Nagano T, Park J, et al. The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma. Anticancer Res. 2022; 42: 1589-98.

Saji N, Saito Y, Yamashita T, et al. Relationship between plasma lipopolysaccharides, gut microbiota, and dementia: a cross-sectional study. Journal of Alzheimer's Disease. 2022; 86: 1947-57.

Yoshida N, Watanabe S, Yamasaki H, et al. Average gut flora in healthy Japanese subjects stratified with age and body mass index. Biosci Microbiota Food Health. 2022; 41: 45-53.

Hayashi T, Yamashita T, Takahashi T, et al. Uncovering the Role of Gut Microbiota in Amino Acid Metabolic Disturbances in Heart Failure Through Metagenomic Analysis. Front Cardiovasc Med. 2021; 8: 789325.

Yoshida N, Yamashita T, Osone T, et al. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience. 2021; 24: 103342.

Emoto T, Hayashi T, Tabata T, et al. Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. Int J Cardiol. 2021; 338: 138-42.

Tabata T, Yamashita T, Hosomi K, et al. Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs. Heart Vessels. 2021; 36: 105-14.

臨床研究（J-ROAD; 日本循環器学会のデータベースを使用)

Ogawa M, Ishihara K, Kanejima Y, et al. Impact of Body Mass Index on Hospital-associated Disability and Economic Burden in Elective Cardiovascular Surgery: Insights from the JROAD/JROAD-DPC Database. Circ J. in press.

Kanejima Y, Ogawa M, Ishihara K, et al. U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline. Neurol Res. 2025; 47: 296-305.

Ogawa M, Satomi-Kobayashi S, Yoshida N, et al. Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on cardiac surgery: A randomized controlled trial. Clin Nutr. 2025; 45: 91-100.

Kanejima Y, Ogawa M, Ishihara K, et al. Body mass index is associated with disability at discharge as indicated by the modified Rankin Scale in patients with ischemic stroke: a JROAD-DPC study. Top Stroke Rehabil. 2024: 1-10.

Yoshida N, Ogawa M, Nakai M, et al. Impact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan. Sci Rep. 2022; 12: 18934.

Ogawa M, Yoshida N, Nakai M, et al. Hospital-associated disability and hospitalization costs for acute heart failure stratified by body mass index- insight from the JROAD/JROAD-DPC database. Int J Cardiol. 2022; 367: 38-44.

臨床研究

Yoshida N, Iwata S, Ogawa M, et al. Intensive Care Unit Admission for Moderate-to-Severe COVID-19 Patients With Known Cardiovascular Diseases or Their Risk Factors - Insights From a Nationwide Japanese Cohort Study. Circ Rep. 2021; 3: 375-80.

Yoshida N, Kitahama S, Yamashita T, et al. Metabolic alterations in plasma after laparoscopic sleeve gastrectomy. J Diabetes Investig. 2021; 12: 123-9.

Komaki K, Yoshida N, Satomi-Kobayashi S, et al. Preoperative frailty affects postoperative complications, exercise capacity, and home discharge rates after surgical and transcatheter aortic valve replacement. Heart Vessels. 2021; 36: 1234-45.

Suehiro H, Kiuchi K, Fukuzawa K, et al. Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation. J Cardiovasc Electrophysiol. 2021 ;32: 1035-43.

その他

Horibe S, Emoto T, Mizoguchi T, Tanaka T, Kawauchi S, Sasaki N, Yamashita T, Ikeda K, Emoto N, Hirata K, Rikitake Y. Endothelial senescence alleviates cognitive impairment in a mouse model of Alzheimer's disease. Glia. 2024; 72: 51-68.

Kasahara K, Sasaki N, Amin HZ, Tanaka T, Horibe S, Yamashita T, Hirata K, Rikitake Y. Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice. Heliyon. 2022; 8: e09981.