Publications

Single cell analysis

Emoto T, Yamamoto H, Yamashita T, Takaya T, Sawada T, Takeda S, Taniguchi M, Sasaki N, Yoshida N, Saito Y, Sivasubramaniyam T, Otake M, Furuyashiki T, Robbins SC, Kawai H, Hirata K. Single Cell RNA Seq Reveals a Distinct Immune Landscape of Myeloid Cells in Coronary Culprit Plaques Causing Acute Coronary Syndrome. Circulation. 2022; 145: 1434-36.

Gut microbiota and Diseases

Shinohara R, Nakashima H, Emoto T, Yamashita T, Saito Y, Yoshida N, Inoue T, Yamanaka K, Okada K, Hirata K. Gut Microbiota Influence the Development of Abdominal Aortic Aneurysm by Suppressing Macrophage Accumulation in Mice. Hypertension. 2022; 79: 2821-2829.

Saito Y, Yamashita T, Yoshida N, Emoto T, Takeda S, Tabata T, Shinohara M, Kishino S, Sugiyama Y, Kitamura N, Yamamoto H, Takaya T, Ogawa J, Hirata K. Structural differences in bacterial lipopolysaccharides determine atherosclerotic plaque progression by regulating the accumulation of neutrophils. Atherosclerosis. 2022; 358: 1-11.

Otoshi T, Nagano T, Park J, Hosomi K, Yamashita T, Tachihara M, Tabata T, Sekiya R, Tanaka Y, Kobayashi K, Mizuguchi K, Itoh T, Maniwa Y, Kunisawa J, Nishimura Y. The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma. Anticancer Res. 2022; 42: 1589-98.

Saji N, Saito Y, Yamashita T, Murotani K, Tsuduki T, Hisada T, Sugimoto T, Niida S, Toba K, Sakurai T. Relationship between plasma lipopolysaccharides, gut microbiota, and dementia: a cross-sectional study. Journal of Alzheimer's Disease. 2022; 86: 1947-57.

Yoshida N, Watanabe S, Yamasaki H, Sakuma H, Takeda KA, Yamashita T, Hirata K. Average gut flora in healthy Japanese subjects stratified with age and body mass index. Biosci Microbiota Food Health. 2022; 41: 45-53.

Hayashi T, Yamashita T, Takahashi T, Tabata T, Watanabe H, Gotoh Y, Shinohara M, Kami K, Tanaka H, Matsumoto K, Hayashi T, Yamada T, Hirata K. Uncovering the Role of Gut Microbiota in Amino Acid Metabolic Disturbances in Heart Failure Through Metagenomic Analysis. Front Cardiovasc Med. 2021; 8: 789325.

Yoshida N, Yamashita T, Osone T, Hosooka T, Shinohara M, Kitahama S, Sasaki K, Sasaki D, Yoneshiro T, Suzuki T, Emoto T, Saito Y, Ozawa G, Hirota Y, Kitaura Y, Shimomura Y, Okamatsu-Ogura Y, Saito M, Kondo A, Kajimura S, Inagaki T, Ogawa W, Yamada T, Hirata K. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience. 2021; 24: 103342.

Emoto T, Hayashi T, Tabata T, Yamashita T, Watanabe H, Takahashi T, Gotoh Y, Kami K, Yoshida N, Saito Y, Tanaka H, Matsumoto K, Hayashi T, Yamada T, Hirata K. Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure. Int J Cardiol. 2021; 338: 138-42.

Tabata T, Yamashita T, Hosomi K, Park J, Hayashi T, Yoshida N, Saito Y, Fukuzawa K, Konishi K, Murakami H, Kawashima H, Mizuguchi K, Miyachi M, Kunisawa J, Hirata K. Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs. Heart Vessels. 2021; 36: 105-14.

Clinical Research （J-ROAD; Database of Japanese Circulation Society)

Yoshida N, Ogawa M, Nakai M, Kanaoka K, Sumita Y, Emoto T, Saito Y, Yamamoto H, Izawa KP, Sakai Y, Hirota Y, Ogawa W, Iwanaga Y, Miyamoto Y, Yamashita T, Hirata K. Impact of body mass index on in-hospital mortality for six acute cardiovascular diseases in Japan. Sci Rep. 2022; 12: 18934.

Ogawa M, Yoshida N, Nakai M, Kanaoka K, Sumita Y, Kanejima Y, Emoto T, Saito Y, Yamamoto H, Sakai Y, Hirota Y, Ogawa W, Iwanaga Y, Miyamoto Y, Yamashita T, Izawa KP, Hirata K. Hospital-associated disability and hospitalization costs for acute heart failure stratified by body mass index- insight from the JROAD/JROAD-DPC database. Int J Cardiol. 2022; 367: 38-44.

Clinical Research

Yoshida N, Iwata S, Ogawa M, Izawa KP, Kuroda S, Kohsaka S, Yonetsu T, Kitai T, Torii S, Sano T, Sakai Y, Yamashita T, Hirata K, Matsue Y, Matsumoto S, Node K. Intensive Care Unit Admission for Moderate-to-Severe COVID-19 Patients With Known Cardiovascular Diseases or Their Risk Factors - Insights From a Nationwide Japanese Cohort Study. Circ Rep. 2021; 3: 375-80.

Yoshida N, Kitahama S, Yamashita T, Hirono Y, Tabata T, Saito Y, Shinohara R, Nakashima H, Emoto T, Hirota Y, Takahashi T, Ogawa W, Hirata K. Metabolic alterations in plasma after laparoscopic sleeve gastrectomy. J Diabetes Investig. 2021; 12: 123-9.

Komaki K, Yoshida N, Satomi-Kobayashi S, Tsuboi Y, Ogawa M, Wakida K, Toba T, Kawamori H, Otake H, Omura A, Yamanaka K, Inoue T, Yamashita T, Sakai Y, Izawa KP, Okada K, Hirata K. Preoperative frailty affects postoperative complications, exercise capacity, and home discharge rates after surgical and transcatheter aortic valve replacement. Heart Vessels. 2021; 36: 1234-45.

Suehiro H, Kiuchi K, Fukuzawa K, Yoshida N, Takami M, Watanabe Y, Izawa Y, Akita T, Takemoto M, Sakai J, Nakamura T, Yatomi A, Takahara H, Sonoda Y, Nakasone K, Yamamoto K, Yamashita T, Hirata K. Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation. J Cardiovasc Electrophysiol. 2021 ;32: 1035-43.

Inflammation in Atherogenesis

Kasahara K, Sasaki N, Amin HZ, Tanaka T, Horibe S, Yamashita T, Hirata K, Rikitake Y. Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice. Heliyon. 2022; 8: e09981.