Akazawa H, Fukuda I, Kaneda H, Yoda S, Kimura M, Nomoto R, Ueda S, Shirai Y, Osawa R. (2023) Isolation and identification of hyaluronan-degrading bacteria from Japanese fecal microbiota. PLoS one, 18(5), e0284517, Doi:10.1371/journal.pone.0284517
2022
Hayashi D, Shirai Y. (2022) The Role of Diacylglycerol Kinase in the Amelioration of Diabetic Nephropathy. Molecules, 27(20), 6784-6799, Doi:10.3390/molecules27206784
Ueda S, Nishihara M, Hioka Y, Yoshino K, Yamada S, Yamanoue M, Shirai Y. (2022) Polo-Like Kinase 2 Plays an Essential Role in Cytoprotectionagainst MG132-Induced Proteasome Inhibition via Phosphorylation of Serine 19 in HSPB5. International Journal of Molecular Sciences, 23(19), 11257-11275, Doi:10.3390/ijms231911257
Ueda S, Takashima Y, Gotou Y, Sasaki R, Nakabayashi R, Suzuki T, Sasazaki S, Fukuda I, Kebede B, Kadowaki Y, Tamura M, Nakanishi H, Shirai Y. (2022) Application of Mass Spectrometry for Determining the Geographic Production Area of Wagyu Beef. Metabolites, 12(9), 777, Doi:10.3390/metabo12090777
Hayashi D, Mouchlis VD, Okamoto S, Namba T, Wang L, Li S, Ueda S, Yamanoue M, Tachibana H, Arai H, Ashida H, Dennis EA, Shirai Y. (2022) Vitamin E functions by association with a novel binding site on the 67 kDa laminin receptor activating diacylglycerol kinase. Journal of Nutritional Biochemistry, 110, 109129-109131
Ueda S, Hosoda M, Kasamatsu K, Horiuchi M, Nakabayashi R, Kang B, Shinohara M, Nakanishi H, Ohto-Nakanishi T, Yamanoue M, Shirai Y. (2022) Production of Hydroxy Fatty Acids, Precursors of γ-Hexalactone, Contributes to the Characteristic Sweet Aroma of Beef. Metabolites, 4, 332. Doi:10.3390/metabo12040332
Chinthammit B, Okamoto S, Shirai Y. (2022) Almond Skin Polyphenol Extracts Stimulate the Activation of Diacylglycerol Kinase alpha via a 67 kDa Laminin Receptor. Functional Food in Health and Disease, 12, 151-160, Doi:10.31989/ffhd.v12i4.894
Okada N, Sugiyama K, Shichi S, Shirai Y, Goto K, Sakane F, Kitamura H, Taketomi A. (2022) Combination therapy for hepatocellular carcinoma with diacylglycerol kinase alpha inhibition and anti-programmed cell death-1 ligand blockade. Cancer Immunology, Immunotherapy, 71, 889-903.
2021
Kano T, Tsumagari R, Nakashima A, Kikkawa U, Ueda S, Yamanoue M, Takei N, Shirai Y. (2021) RalA, PLD and mTORC1 Are Required for Kinase-Independent Pathways in DGKβ-Induced Neurite Outgrowth. Biomolecules, 11, 1814-. Doi:10.3390/biom11121814
Matui S, Akazawa H, Tsujikawa Y, Fukuda I, Suzuki Y, Yamamoto Y, Mukai T, Shirai Y and Osawa R. (2021) Milk oligosaccharide-mediated cross-feeding between Enterococcus gallinarum and lactobacilli in the gut microbiota of infant rats. Bioscience of Microbiota, Food and Health, 40, 204-211.
Ueda S, Sasaki R, Nakabayashi R, Yamanoue M, Shirai Y, Iwamoto E. (2021) Exploring the Lipids Involved in the Formation of Characteristic Lactones in Japanese Black Cattle. Metabolites, 11, 203. Doi:10.3390/metabo11040203
Tsumagari R, Maruo K, Nakao T, Ueda S, Yamanoue M, Shirai Y. (2021) Motor dyscoordination and alteration of functional correlation between DGKγ and PKCγ in senescence-accelerated mouse prone 8 (SAMP8). Frontier in aging neuroscience 13, 573966.
Shirai Y, Kobayashi H, Ueda S, Yun SS, Kushiya A, Tsumagari R, Yamanoue M. (2021). Protective effect of Zingiber zerumbet Smith extract on thermotolerance. Bioactive Conpound in Helath and Disease 4, 1-8.
Ueda S, Yamanoue M, Shirai Y, Iwamoto E. (2021) Exploring the Characteristic Aroma of Beef from Japanese Black Cattle (Japanese Wagyu) via Sensory Evaluation and Gas Chromatography-Olfactometry. Metabolites 11, 56
2020
Hayashi D, Wang K, Ueda S, Yamanoue M, Ashida H, Shirai Y. (2020) The mechanisms of ameliorating effect of a green tea polyphenol on diabetic nephropathy based on diacylglycerol kinase α. Sci Rep. 10, 11790.
Tsumagari R, Maruo K, Kakizawa S, Ueda S, Yamanoue M, Saito H, Suzuki N, Shirai Y. (2020) Precise Regulation of the Basal PKCγ Activity by DGKγ Is Crucial for Motor Coordination. International Journal of Molecular Sciences 21; 7866. (doi.org/10.3390/ijms21217866).
Zhao Y, Nishida M, Ueda S, Shirai Y, Habara M, Ikezaki H, Yamanoue M. (2020) Comparative Study of the Effects of Different Pretreatment Procedures on Beef Taste-traits Using an Electronic Taste Sensing System. Food Science and Technology Research 26, 329-338.
Tsumagari R, Kakizawa S, Kikunaga S, Fujihara Y, Ueda S. Yamanoue M, Saito N, Ikawa M, Shirai Y. (2020) DGKγ knock-out mice show impairments in cerebellar motor coordination, LTD, and the dendritic development of Purkinje cells through the activation of PKCγ eNeuro 0319.
Nakai, H Tsumagari R, Maruoa K, Nakashima A, Kikkawa U, Ueda S, Yamanoue M, Saito N, Takei N, Shirai Y. (2020) mTORC1 is involved in DGKβ-induced neurite outgrowth and spinogenesis. Neurochem. Intl 134, 104645.
2019
Hayashi D, Tsumagari R, Liu K, Ueda S, Yamanoue M, Sakane F, Shirai Y. (2019) Screening of subtype specific activators and inhibitors for diacylglycerol kinase. J Biochem. 165, 517-522. Feb 4. doi: 10.1093/jb/mvz008. [Epub ahead of print]
2018
Yamaki A, Akiyama R, Murakami C, Takao S, Murakami Y, Mizuno S, Takahashi D, Kado S, Taketomi A, Shirai Y, Goto K, Sakane F. (2018) Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines. J Cell Biochem. 120, 10043-10056.
Sakaguchi K, Shirai Y, Itoh T, Mizuno M. (2018) Lentinan Exerts its Anti-Inflammatory Activity by Suppressing TNFR1 Transfer to the Surface of Intestinal Epithelial Cells through Dectin-1 in an in vitro and mice model. Immunome Research. 14, 1000165.
Ueda-Wakagi M, Hayashibara K, Nagano T, Ikeda M, Yuan S, Ueda S, Shirai Y, Yoshida KI, Ashida H. (2018) Epigallocatechin gallate induces GLUT4 translocation in skeletal muscle through both PI3K- and AMPK-dependent pathways. Food Funct. 15, 4223-4233.
Nakano T, Ogasawara S, Tanaka T, Hozumi Y, Yamaki A, Sakane F, Shirai Y, Nakamura T, Yanaka M, Yamada S, Kaneko MK, Kato Y, Goto K. (2018) DgMab-6: Antihuman DGKγ Monoclonal Antibody for Immunocytochemistry. Monoclon Antib Immunodiagn Immunother. 37, 229-232.
Ueda S, Iwamoto E, Kato Y, Shinohara M, Shirai Y, Yamanoue M. (2018) Comparative metabolomics of Japanese Black cattle beef and other meats using gas chromatography-mass spectrometry. Biosci Biotechnol Biochem. 83, 137-147.
Hayashi D, Ueda S, Yamanoue M, Ashida H, Shirai Y. (2018) Amelioration of diabetic nephropathy by oral administration of d-α-tocopherol and its mechanisms. Biosci Biotechnol Biochem. 82, 65-73.
2017
Kakehi T, Yagi K, Saito N, Shirai Y. (2017) Effects of vitamin E and its derivatives on diabetic nephropathy in Rats and identification of diacylglycerol kinase subtype involved in the improvement of diabetic nephropathy. Functional Foods in Health and Disease. 7, 816-832.
Hayashi D, Yagi K , Song C, Ueda S, Yamanoue M, Topham M, Suzaki T, Saito N, Emoto N, Shirai Y. (2017) Diacylglycerol Kinase alpha is Involved in the Vitamin E-Induced Amelioration of Diabetic Nephropathy in Mice. Sci Rep. 7, 2597-2604.
2016
Mitani T, Yoshioka Y, Furuyashiki T, Yamashita Y, Shirai Y, Ashida H. (2016) Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress. Free Radic Biol Med. 106, 355–367.
Lui K, Kunii N, Sakuma M, Yamaki A, Mizuno S, Sato M, Sakai H, Kado S, Kumagai K, Kojima H, Okabe T, Nagano T, Shirai Y. and Sakane F. (2016) A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J lipid res. 57, 368-379.
2015
Ueda S, Kokaji Y, Shimizu S, Honda K, Yoshino K, Kamisoyama H, Shirai Y and Yamanoue M. (2015) Chicken heat shock protein HSPB1 increases and interacts withαB-crystallin in aged skeletal muscle. Bioscience Biotechnology and Biochemistry 79,1867-1875.
Hayashi D, Ueda S, Yamanoue M, Saito N, Ashida H and Shirai Y. (2015) Epigallocatechin-3-gallate activates diacylglycerol kinase alpha via a 67 kDa laminin receptor: a possibility of galloylated catechins as functional food to prevent and/or improve diabetic renal dysfunctions. J. Functional Food 15, 561-569
2014
Shirai Y, Saito N. (2014) Diacylglycerol kinase as a possible therapeutic target for neuronal diseases. J Biomed Sci. 2014 Apr 7;21(1):28. [Epub ahead of print].
Kano T, Kouzuki T, Mizuno S, Ueda S, Yamanoue M, Sakane F, Saito Y, Shirai Y. (2014) Both the C1 domain and a basic amino acid cluster at the C-terminus are important for the neurite and branch induction ability of DGKβ. Biochem. Biophys. Res. Comm. 447, 89-94.
Sakuma M, Shirai Y, Ueyama T, Saito N. (2014) Diacylglycerol kinase γ regulates antigen-induced mast cell degranulation by mediating Ca(2+) influxes. Biochem Biophys Res Commun. 445, 340-350.
2013
Ueda S, Becky T, Yamanoue M, Daniel R. and Shirai Y. (2013). The expression of diacylglycerol kinase theta during the organogenesis of mouse embryos. BMC Developemental Biology 13:35.
Kurohane-Kaneko Y, Kobayashi, Y, Motoki K, Nakata K, Miyagawa S, Yamamoto M, Hayashi D, Shirai Y, Sakane F, and Ishikawa T. (2013) Depression of type I diacylglycerol kinases in pancreatic β-cells from male mice results in impaired insulin secretion. Endocrinology 154, 4089-4098.
Wood TR, Chow RY, Hanes CM, Zhang X, Kashiwagi K, Shirai Y, Treback M, Loegering DJ, Saito N and Lennartz MR (2013) PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-Mediated Phagocytosis. J. Leukocyte Biol. 94, 109-122
Ishisaka M, Tsuruma K, Shimazawa M, Shirai Y, Saito N and Hara H.(2013) Increased seizure susceptibility in a mouse with diacylglycerol kinase β deficiency. Neuroscience & Medicine, 4, 117-122.
Nishimoto T, Kashiwagi K, Saito N and Shirai Y. (2013) Both C1B domain and pseudosubstrate region are necessary for saturated fatty acid-induced translocation of εPKC to the plasma membrane: Distinct role of intramolecular domains for different translocation. Biochem. Biophys. Res. Comm. 432, 384-388.
2012
Sakuma M, Shirai Y, Yoshino K, Kuramasu M, Nakamura T, Yanagita T, Mizuno K, Hide I, Nakata Y and Saito N. (2012) Novel PKCα-mediated phosphorylation site(s) on cofilin and their potential role in terminating histamine release. Mol. Biol. Cell 23, 3707-3721.
Shirai Y, Saito N. (2012) Diacylglycerol kinase (DGK) as a regulator of PKC. In Protein Kinase Technologies (Ed. H. Mukai), Neuromethods 68, 259-271.
Shirai Y, Ikeda M. and Saito N. (2012) Regulation of diacylglycerol kinase by phosphorylation. Adv. biological. Reg. 52, 239-247.
Matsubara M, Ikeda M, Kiso Y, Sakuma M, Sakane F, Merida I, Saito N. and Shirai Y. (2012) c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr218. J. Biol. Chem. 287:5507-5517.
2011
Shibata Y, Kawada-matsuo M, Shirai, Y, Saito N, Li D. and Yamashita Y. (2011) Streptococcus mutans diacylglycerol kinase homologue: a potential target for anti-caries chemotherapy. J. Medical Microbiol. 60, 625-630.
Shirai Y, Morioka S, Sakuma M, Yoshino K, Otsuji C, Sakai N, Kashiwagi K, Chida K, Shirawaka R, Horiuchi H, Nishigori C, Ueyama T and Saito N. (2011) Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation. Mol. Biol. Cell 22, 1340-1352.
Mukai R, Terao J, Shirai Y, Saito N, and Ashida H. (2011) Determination of subcellular localization of Flavonol in cultured cells by laser scanning. 215-232.
2010
Kakefuda K, Oyagi A, Ishisaka M, Tsumura K, Shimazawa M, Yokota K, Shirai Y, Horie K, Saito N, Takeda J and Hara H. (2010) Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE 5. e13447.
Mukai R, Shirai Y, Saito N, Fukuda I, Nishiumi S, Yoshida K and Ashida H. (2010) Suppression mechanisms of flavaonoids on aryl hydrocarbon receptor-mediated signal transduction. Arch. Biochem. Biophys. 501, 134-141.
Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita S, Shimazawa M, Fukunaga K, Takeda J, Saito N and Hara H. (2010) Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKβ in neurite spine formation, contributing to cognitive function. PLoS ONE 5. e11602-
Yanase Y, Hide I, Mihara S, Shirai Y, Saito N, Nakata Y, Hide M. and Sakai N. A critical role of conventional protein kinase C in morphological changes of rodent mast cells. (2010) Immunol. Cell. Biol. 89, 149-159.
2009
Takaoka K, Shirai Y and Saito N. (2009) Inflammatory cytokine TNF-alpha enhances NGF production in human keratinocytes, HaCaT cells. J. Pharmacol. Sci. 111, 381-391.
Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A. and Hirotsune H. (2009) An essential role of the aPKC-aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics. Nature Cell Biol. 11, 1057-1068.
Mukai R, Shirai Y, Saito N, Yoshida K and Ashida H. (2009) Subcellular localization of flavonol aglycone in hepatocytes visualized by confocal laser scanning fluorescence microscope. Cytotechnology 59, 177-182.
Shibata Y, van der Ploeg JR, Kozuki T, Shirai Y, Saito N, Kawada-Matsuo M, Takeshita T and Yamashita Y. (2009) Kinase activity of the dgk gene product is involved in the virulence of Streptococcus mutants. Microbiology 155, 557-565.
2008
Ashida N, Ueyama T, Rikitake K, Shirai Y, Eto M, Kondo T, Koumura E and Saito N. (2008) Ca2+ oscillation induced by P2Y2 receptor activation and its regulation by a neuron-specific subtype pf PKC (γPKC). Neurosci Lett. 446, 123-128
Ibi M, Matsuno K, Shiba D, Katsuyama M, Iwata K, Kakehi T, Nakagawa T, Sango K, Shirai Y., Y.koyama T, Kaneko S, Saito N. and Yabe-Nishimura C. (2008) Reactive oxygen species derived from Nox1/NADPH oxidase enhance inflammatory pain. J. Neuroscience 28, 9486-9494.
Shirai Y, Adachi N and Saito N. (2008) Protein kinase Cε function in neurons. FEBS J. 275, 3988-3994.
Adachi N, Kobayashi T, Takahashi H, Kawasaki T, Shirai Y., Ueyama T, Matsuda T, Seki T, Sakai N and Saito N. (2008) Enzymological analysis of mutant protein kinse Cγ causing spinocerebellar ataxia type 14 and dysfunction in Ca2+ homeostasis. J. Biol. Chem 283, 19854-19863.
Merino E, Avila-Flores A, Shirai Y, Moraga I, Saito N and Merida I (2008) Lck-dependent tyrosine phosphorylation of diacylglycerol kinase α regulates its membrane association in T cells. J. Immunol. 180, 5805-5815.
Kawasaki T, Kobayashi T, Ueyama T, Shirai Y and Saito N. (2008) Regulation of clathrin-dependent endocytosis by diacylglycerol kinase δ importance of kinase activity and binding to AP2α. Biochem J. 409, 471-479.
2007
Shirai Y, Murakami T, Kuramasu M, Iijima L, and Saito N. (2007) Novel PIP2 binding of εPKC and its correlation to neurite induction. J Neurochem. 102, 1635-1644.
Ueyama T, Tatsuno T, Kawasaki T, Tsujibe S, Shirai Y, Sumimoto H, Leto T and Saito N. (2007) A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p47phox. Mol. Biol. Cell 18, 441-454.
2006
Yamaguchi Y, Shirai Y, Matsubara T, Sanse K, Kuriyama K, Oshiro N, Yoshino K, Yonezawa K, Ono Y and Saito N. (2006) Phosphorylation and up-regulation of diacylglycerol kinase γ via its interaction with protein kinase C γ. J. Biol. Chem 281, 31627-31637.
Matsubara T, Shirai Y, Miyasaka K, Murakami T, Yamaguchi Y, Ueyama T, Kai M, Sakane F, Kanoh H, and Saito N. (2006) Nuclear transportation of diacylglycerol kinase γ and its possible function in the nucleus. J. Biol. Chem. 281, 6152-6164.
Cheeseman LK, Ueyama T, Michaud MT, Kashiwagi K, Wang D, Flax LA, Shirai Y, Loegering, DJ, Saito N. and Lennartz MR. (2006) Targeting of PKC-ε during FcγR-dependent phagocytosis requires the εC1B domain and phospholipase C-γ1. Mol. Biol. Cell.17, 799-813.
Masukawa K, Sakai N, Ohmori S, Shirai Y and Saito N. (2006) Spatiotemporal analysis of the molecular interaction between PICK1 and PKC. Acta Histochem. Cytochem. 39, 173-181.
Sato K, Adachi T, Shirai Y, Saito N and Tomita Y. (2006) Local disassembly of actin stress fibers induced by selected release of intracellular tension in osteoblastic cells. J Biomech. Sci. Eng. 1, 204-214.
2005
Adachi N, Oyasu M, Taniguchi T, Yamaguchi Y, Takenaka R, Shirai Y, and Saito N. (2005) Immunocytochemical localization of a neuron-specific diacylglycerol kinase β and γ in the developing rat brain. Mol. Brain Res. 139, 288-299
Abdel-Raheem IT, Hide I, Yanase Y, Shigemoto-Mogami Y, Sakai N, Shirai Y, Saito N, Hamada, FR, El-Mahdy NA, Elsisy AEDE, Sokar SS and Nakata Y (2005) Protein kinase C-α mediates TNF release process in RBL-2H3 mast cells. British J. Pharmcol. 145, 415-423.
Ueyama T, Eto M, Tatsuno T, Kobayashi T, Shirai Y, Lennarts MR, Takrya R, Sumimoto H, and Saito N.(2005) Isoform-specific membrane targeting mechanism of rac during FcγR-mediated phagocytosis: Positive charge-dependent and independent targeting of mechanism of Rac to the phagosome. J. Immunol. 175, 2381-2390.
Shirai Y, Balsinde J. and Dennis E. (2005) Localization and Functional Interrelationships Among Cytosolic Group IV, Secreted Group V, and Ca2+-Independent Group VI Phospholipase A2s in P388D1 Macrophages Using GFP/RFP Constructs. Biochemica Biocphyca Acta. 1735, 119-129.
Fukunaga-Takenaka R, Shirai Y, Yagi K, Adachi N, Sakai N, Merino E, Merida I and Saito N. (2005) Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by d-α-tocophenol. Genes to Cells. 10, 311-319.
2004
Kuriyama M, Taniguchi T, Shirai Y, Sasaki A, Yoshimura A and Saito N (2004) Activation and translocation of PKCδ is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem. Biophys. Res. Comm. 325, 843-851.
Seki T, Matsubayashi H, Amano T, Shirai Y, Saito N and Sakai N (2004) Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes to cells 10, 945-957.
Sakai N, Tsubokawa H, Matsuzaki M, Kajimoto T, Takahashi E, Ren Y, Ohmori S, Shirai Y, Matsubayashi H, Chen J, Duman RS, Kasai H, and Saito N. (2004) Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC-GFP transgenic mice. Genes to cells 9, 945-957.
Ueyama T, Lennartz MR, Noda Y, Kobayashi T, Shirai Y, Rikitake K, Yamasaki T, Hayashi S, Sakai N, Seguchi H, Sawada M, Sumimoto H, and Saito N. (2004) Superoxide production at phagosomal cup/phagosome through betaI protein kinase C during FcγR-mediated phagocytosis in microglia. J Immunol. 173, 4582-4589.
Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, and Saito N (2004) Ceramide-induced apoptosis by translocation, phosphorylation and activation of protein kinase C γ in the Golgi complex. J. Biol. Chem. 279, 12668-12676.
Yagi K, Shirai Y, Hirai M, Sakai N and Saito N. (2004) Phospholipase A2 products retain a neuron specific γ isoform of PKC on the plasma membrane through the C1 domain- a molecular mechanism for sustained enzyme activity. Neurochem Inter. 45, 39-47
2003
Uchino M, Sakai N, Kashiwagi K, Shirai Y, Shinohara Y, Hirose K, Iino M, Yamamura T, and Saito N (2003) Isoform-specific phosphorylation of mGluR5 by PKC blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC. J. Biol. Chem. 279, 2254 – 2261
Balboa M, Shirai Y, Gaietta G, Ellisman M, Balsinde J and Dennis E. (2003) Localization of Group V Phospholipase A2 in Caveolin-enriched Granules in Activated P388D1 Macrophage-like Cells. J. Biol. Chem. 278, 48059 – 48065.
Shindo M, Irie K, Masuda A, Ohigashi H, Shirai Y, Miyasaka K and Saito N (2003) Synthesis and Phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. J. Biol. Chem. 278, 18448-18454.
Sakai K, Hasegawa C, Okura M, Morikawa O, Ueyama T, Shirai Y, Sakai N and Saito N. (2003) Novel variants of murine serotonin transporter mRNA and the promoter activity of its upstream site. Neurosci. Lett. 342, 175-178.
2002
Irie N, Sakai N, Ueyama T, Kajimoto T, Shirai Y and Saito N (2002) Subtype- and species-specific knocckdown of PKC using short interfering RNA (siRNA) Biochem. Biophys. Res. Comm. 298, 738-743.
Larsen CE, Ueyama T, Brannock MP, Shirai Y, Saito N, Larsson C, Loegering DD, Weber BP and Lennartz RM. (2002) A Role for PKC-ε in FcγR-mediated phagocytosis by RAW 264.7 cells. J. Cell Biol. 159, 939-944.
Shirai Y and Saito N (2002) Activation Mechanism of Protein kinase C: maturation, catalytic activation, and targeting. J Biochem 132, 663-668.
Saito N and Shirai Y. (2002) Protein kinase Cγ (PKCγ): Function of neuron specific isotype. J Biochem 132, 683-687.
Kashiwagi K, Shirai Y, Sakai N, Kuriyama M and Saito N. (2002) Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C. J. Biol. Chem. 277, 18037-18045.
Sakai K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y and Saito N. (2002) The silencer activity of the novel human serotonin transporter linked polymorphic regions. Neuroscience Lett. 327, 13-16.
2001
Shirai Y, Jiang Y, Yoshioka S and Aizono Y (2001) The release of an insect neuropeptide formone, bombyxin, is regulated by muscarinic transmission in the brain-corpus cardiacum- corpus allatum complex of the silkworm, Bombyx mori (Lepidoptera: Bombycidae). Appl. Entomol. Zool. 36,: 431- 438.
Minami T, Hara K, Oshiro N, Ueoku S, Yoshiono K, Tokunaga C, Shirai Y, Saito N, Gout I and Yonezawa K. (2001) Distnct regulatory mechanism for p70 S6 kinase from that for p70 S6 kinase α. Genes to Cells 6, 1003-1015.
Kajimoto T, Ohmori S, Shirai Y, Sakai N and Saito N. (2001) Subtype-specific translocation of the d subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in Hela cells. Mol. Cell. Biol. 21, 1769-1783
2000
Shirai Y, Segawa S, Kuriyama M, Goto K, Sakai N and Saito N. (2000) Subtype-specific translocation of diacylglycerol kinase α and γ and its correlation with protein kinase C. J. Biol. Chem. 275, 24760-24766.
Shirai Y, Kashiwagi K, Sakai N and Saito N. (2000) Phospholipase A2 and its products are involved in the purinergic receptor-mediated translocation of protein kinase C in CHO-K1 cells. J. Cell Sceince. 113, 1335-1343.
Ohmori S, Sakai N, Shirai Y, Yamamoto Y, Miyamoto E, Shimizu N and Saito N. (2000) Importance of PKC targeting for the phosphorylation of its substrate, myristiylated alanine-rich C-kinase substrate. J. Biol. Chem. 275, 26449-26457
Yokogawa T, Nagata S, Nishio Y, Tsusumi T, Ihara S, Shirai R, Morita K, Umeda M, Shirai Y, Saito N and Fukui Y. (2000) Evidence that 3’-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies sepecific for PI 3,4-P(2). FEBS Lett. 473, 222-226.
Sumioka K, Shirai Y, Sakai N, Hashimoto T, Tanaka C, Yamamoto M, Takahashi M, Ono Y and Saito N. (2000) Induction of 55kDa protein of PKN by ischemia/reperfusion model of ratretina. Invest. Opthal. Vis. Sci. 41, 29-35.
1999
Takahashi H, Konishi H, Matsuzaki H, Ono Y, Shirai Y, Saito N, Kitamura T, Ogawa W, Kasuga M, Kikkawa U and Nishizuka Y. (1999) Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B. Proc. Natl. Sci. USA. 96, 11836-11841.
Ren Yi, Shirai Y and Saito N. (1999) Serotonergic neurotransmission in Taste buds of rat ; immunocytochemical study of serotonin and serotonin transporter. Mol. Brain Res. 74, 221-224.
1998
Shirai Y, Kashiwagi K, Yagi K, Sakai N and Saito N. (1998) Distinct Effect of fatty acids on translocation of γ- and ε-subspecies of protein kinase C. J. Cell Biol. 143, 511-521.
Yamamoto H, Fujimiya M, Shirai Y, Nakashita M, Oyasu M and Saito N. (1998) Immunohistochemical localization of serotonin transporter in normal and colchicine treated rat brain. Neurosci. Res. 32, 305-312.
Ohmori S, Shirai Y, Sakai N, Fujii M, Konishi H, Kikkawa U and Saito N (1998) Three distinct mechanisms for translocation and activation of the d subspecies of protein kinase C. Mol. Cell. Biol. 18, 5263-5271.
Shirai Y, Sakai N and Saito N. (1998) Subspecies-Specific Targeting Mechanism of Protein Kinase C. Jap. J. Pharmacol. 78, 411-417.
Uno T, Ueno M, Nakajima A, Shirai Y and Aizono Y. (1998) Molecular cloning of cDNA for Brab from the brain of Bombyx mori and biochemical prooerties of Brab expressed in Escherichia coli. Biosci. Biotechnol. Biochem. 62, 1885-1891.
Shirai Y, Uno T and Aizono Y (1998) Small GTP-binding proteins in the brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori. Arch. Insect Biochem. Physiol. 38, 177-184.
1997
Sakai N, Sasaki K, Ikegaki N, Shirai Y, Ono Y and Saito N. (1997) Direct visualization of the translocation of γ-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein. J. Cell Biol. 139, 1465-1476.
Shirai Y, Sakamura Y, Sumida M and Aizono Y. (1997) Carbachol-induced protein phosphorylation in the brain-corpus cardiacum-corpus allatum complex of the silkworm, Bombyx mori. Appl. Ent. Zool. 32, 573-581.
Aizono Y, Yamada T, Hirooka K, Takeda M, Matsubara F and Shirai Y. (1997) Cholinergic and serotonergic control of prothoracicotropic hormone release during the pupal stage of the silkworm, Bombyx mori. Appl. Ent. Zool. 32, 508-511.
Aizono Y, Endo Y, Sattelle DB and Shirai Y. (1997) Prothoracicotropic hormone -producing neurosecretory cells in the silkworm, Bombyx mori, express a muscarinic acetylcholine receptor. Brain Res. 763, 131-136.
1995
Shirai Y, Shimazaki K, Iwasaki T, Matsubara F and Aizono Y. (1995) The in vitro release of prothoracicotropic hormone (PTTH) from the brain-corpus cardiacum-corpus allatum complex of silkworm, Bombyx mori. Comp. Biochem. Physiol. 110C, 143-148.
Aizono Y. and Shirai Y. (1995) "Control of prothoracicotropic hormone release with neurotransmitters in silkworm." In Molecular mechanisms of Metamorphosis and Diapose (Ed. Suzuki A. et al.). Industrial Publishing & Consulting, Inc., pp.119-128.
Hosie AM, Shirai Y, Backingham SD, Rauh JJ, Baylis HA. and Sattelle DB. (1995) Blocking actions of BIDN, a bicyclic dinitrile convulsant compound, on wild-type and dieldrin-resistant GABA receptor homo-oligomers of Drosophila melanogaster expressed in Xenopus oocytes. Brain Res. 693, 257-260.
Shirai Y, Hosie AM, Backingham SD, Holyoke Jr. CW., Baylis HA. and Sattelle DB. (1995) Action of picrotoxinin analogues on an expressed, homo-oligomeric GABA receptor of Drosophila melanogaster. Neuroscience Lett. 18, 1-4.
1994
Shirai Y, Iwasaki T, Matsubara F and Aizono Y. (1994) The carbachol-induced release of Prothoracicotropic hormone from brain - corpus cardiacum - corpus allatum complex of the silkworm, Bombyx mori. J. Insect Physiol. 40, 469-473.
1993
Shirai Y, Aizono Y, Iwasaki T, Yanagida A, Mori H, Sumida M and Matsubara F. (1993) Prothoracicotropic hormone is released five times in the 5th-larval instar of the silkworm, Bombyx mori. J. Insect Physiol. 39, 83-88.
1991
Shirai Y, Aizono Y and Iwasaki T. (1991) Monoclonal antibodies specific for ecdysone. Appl. ent. Zool. 62, 335-341.
著書及び学術雑誌総説
著書（総説を含む）
Hayashi D, Shirai Y. (2018) “Protective Role of Alpha-Tocopherol in Diabetic Nephropathy” In Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome. Ed. Debasis Bagchi, ELSEVIER.
Shirai Y, Saito N. (2012) Diacylglycerol kinase (DGK) as a regulator of PKC. In Protein Kinase Technologies (Ed. H. Mukai), Neuromethods 68, 259-271.
Mukai R, Terao J, Shirai Y, Saito N, Ashida H. (2011) Determination of subcellular localization of Flavonol in cultured cells by laser scanning. 215-232.
Aizono Y and Shirai Y. (1995) "Control of prothoracicotropic hormone release with neurotransmitters in silkworm." In Molecular mechanisms of Metamorphosis and Diapose (Ed. Suzuki A. et al.). Industrial Publishing & Consulting, Inc., 119-128.