Publications

BioProduction Engineering Lab Publications Papers 2026

Papers 2026

  1. Wan, C., Wang, XQ., Yue, HR., Zhang, MM., Kondo, A., Haan, RD., Hasunuma, T., Li, K., Zhao, XQ. (2026/01) MDG1-mediated transcriptional reprogramming enhances cellulase production and alters thermal activity in recombinant Saccharomyces cerevisiae, Metabolic Engineering, 93,24-34

  2. Abe, M., Takeuchi, M., Kato, S.,* Hasunuma, T., Groger H., Hayashi T.* (2026/01) Organic solvent-tolerant bacteria as a host for whole-cell biocatalysis: Enzymatic dehydration of aldoximes in organic medium, Journal of Porphyrins and Phthalocyanines, 29, A-F

  3. Kato, S.,* Takeuchi, K., Umeda, K., Kudo, H., Hasunuma, T., Hayashi, T.* (2026/01) PCA-Based Database Mining Enables the Discovery of Bacterial Carbene Transferases for Stereodivergent Cyclopropanation, Angewandte Chemie International Edition, 65(10), e26025

  4. Takeuchi, K., Kato, S.,* Ueshima, R., Hayashi, T.* (2026/01) Directed Evolution Enhances the Peroxidation Activity of Myoglobin Reconstituted with an Iron Corrole Complex, Bulletin of the Chemical Society of Japan, 99(22), uoag024

  5. Li, X., Li, K., Zhang, F., Hasunuma, T., Kondo, A., Zhang, L., Zhao, X., Bai, F. (2026/03) CRISPR-based synthetic biology toolkit development in Candida viswanthii and functional analysis of the stress responsive Ena1-like protein, Synthetic and Systems Biotechnology, 11, 298-308

  6. Tomita, I., Bamba, T., Yoshida, T., Domingues, L., Nasuno, R., Hidese, R., Hasunuma, T. (2026/03) Biosynthetic platform for orsellinic acid-derived meroterpenoids in Escherichia coli, Metabolic Engineering, 94, 231-240

  7. Sekiya, R., Nakamoto, M.,* Kato, S., Hayashi, T., Matsusaki, M.* (2026/03) Injectable and transient hydrogel with programmable lifetime by endogenous coordination crosslinking and enzymatic de-crosslinking, Journal of Controlled Release, 394, 114867

  8. Kato, S.,* Hasunuma, T.* (2026/04) Expanding the Chemical Space of Biosynthesis through Chemistry-Inspired Enzymatic Transformations, Current Opinion in Biotechnology, in press

  9. Minnaar, L.S., Inokuma, K., Hasunuma, T., den Haan, R. (2026/05) Engineering natural Saccharomyces cerevisiae isolates for enhanced one-step cellulosic ethanol production, Applied Microbiology and Biotechnology, in press

  10. Tanaka K*, Kondo A, Hasunuma T*. (2026/05) Systematic determination of disulfide bond reduction potentials reveals a nonequilibrium redox hierarchy in cyanobacteria. Proc Natl Acad Sci U S A., 123, e2600150123

  11. Kawamoto, N., Kawagoe, Y., Yamada, Y., Hamaguchi, K., Shimakawa, G., Hasunuma, T., Tanaka, K., Nakanishi, S. (2025/05) Synchronous oscillation of photosynthetic electricity generation and carbon assimilation, Bioelectrochemistry, 171, 109323

  12. Dai, Z., Aoki, W., Chaiyen, P., Chang, MW., Chen, X., Chen, Z., Cho, BK., Deng, NN., Du, S., Foo, JL., Fredens, J., Fu, M., Han, X., Hasunuma, T., Ichihashi, N., Mat Isa, N., Kiga, D., Kim, DM., Kim, J., Kondo, A., Kosaka, Y., Laoteng, K., Lee, J., Li, J., Li, J., Li, M., Lim, S., Liu, J., Liu, X., Lu, Y., Luo, N., Matsuura, T., Mizunashi, W., Qiao, Y., Ramzi, AB., Seo, SW., Shimizu, Y., Shin, K., Tian, L., Vongsangnak, W., Wang, B., Zhang, CC., Zhang, XE., Zhao, G., Zheng, B., Zhou, Y., Liu, C. (2026/05) A framework for building a synthetic cell from the SynCell Asia Initiative, Nature Biotechnology, https://doi.org/10.1038/s41587-026-03153-w

  13. Nasuno, R., Kudo, H., Fushimi, K., Hidese, R., Kondo, A., Hasunuma, T. (2026/07) Amino acid deaminase outperforms transaminase in α-keto acid production from amino acids, Metabolic Engineering, 96, 234-242

  14. Matsuo, M., Hagino, K., Kawata, S., Hasunuma, T., Honda, K. Achieving Bottom-Up ELSI and RRI in Synthetic Biology Research Community from the Japanese Context, Frontiers in Genetics, in press

  15. Yoshida, T., Shintani, T., Sasaki, D., Vavricka, C., Matsuki, Y., Kondo, A., Hasunuma, T. Development of a quantitative serial LC–MS/MS method for gut microbiota metabolomics, ACS Omega, in press

  16. Kawahara, Y., Nasuno, R., Jin, Y.S., Hasunuma, T. Engineering a robust cell-surface display platform in the multi-stress-tolerant yeast Issatchenkia orientalis, Applied Microbiology and Biotechnology, in press

Reviews & Commentaries

  1. 加藤俊介，有機化学から代謝反応を考える，生物工学会誌 バイオミディア104(2): 68 (2026/02)

  2. 松尾真紀子(東京大学)，松本拓郎(文部科学省)，貴田うらら(経済産業省)，吉田彩乃(文部科学省)，横山修斗(内閣府)，味方和樹(NEDO)，水無渉(神戸大学)，蓮沼誠久(神戸大学)，城山英明(東京大学)，立川雅司(名古屋大学)，バイオものづくり政策の課題と提言－バイオエコノミー社会の実現に向けて， 東京大学未来ビジョン研究センター，政策提言No.40 (2026/05)

  3. 木村友紀，検出素子としての転写因子と遺伝子回路構築による応答調節，ぶんせき，5，155–156 (2026/05)

Books

  1. Tanaka, K., Vavricka, CJ., Hasunuma, T. Metabolomics: Big Data Approaches, Machine Learning and Big Data-enabled Biotechnology, Wiley-VCH, Chapter 10, 263-283 (2026/03)

  2. Nasuno, R., Xie, CY, Kawahara, Y., Tang, YQ., Hasunuma, T. Engineered Microbial Strains for Co-fermentation of C5 and C6 Sugars to Produce Cellulosic Ethanol, Advances in Biochemical Engineering/Biotechnology. Biotechnology for Utilization of Agricultural Residues, Springer, (2026/05)

  3. 木賀大介, 蓮沼誠久（監修）, 合成生物学ハンドブック, 株式会社エヌ・ティー・エス (2026/06)
  4. 西田敬二, 合成生物学ハンドブック, 第１編 合成生物学による科学的探究と基盤技術の開発, 第２章 合成生物学の基盤技術開発と応用研究, 第７節 ゲノム編集の新技術と合成生物学, 株式会社エヌ・ティー・エス, 135-143 (2026/06)
  5. 蓮沼誠久, 田中謙也, 合成生物学ハンドブック, 第３編 合成生物学の産業分野への応用, 第３章 環境・物質生産分野への応用, 第１節 バイオ×デジタルの技術融合によるスマートセル創出と低炭素化技術への応用, 株式会社エヌ・ティー・エス, 395-406 (2026/06)
  6. 加藤俊介, 合成生物学ハンドブック, 第３編 合成生物学の産業分野への応用, 第３章 環境・物質生産分野への応用, 第７節 有機合成化学に学ぶ非生物学的な酵素反応の開発, 株式会社エヌ・ティー・エス, 460-467 (2026/06)

  7. Wang, WB., Bamba, T., Cheng, C., Hasunuma, T., Kondo, A., Zhao, XQ., Bai, FW. Chapter 7. Metabolic engineering of microbial strains for 1,2,4-butanetriol production: progress and future perspectives, Advances in Biochemical Engineering/Biotechnology. Biotechnology for Utilization of Agricultural Residues, Springer, (2026/)