メンバー紹介

TOP メンバー（先端バイオ） 野井　健太郎

特命助教野井　健太郎 Kentaro Noi

経歴

2005/03
鳥取大学　工学部　生物応用学科　卒業
2007/03
鳥取大学　大学院医学系研究科　機能再生医科学専攻　博士前期課程　修了
2010/03
鳥取大学　大学院医学系研究科　機能再生医科学専攻　博士後期課程　修了（再生医科学）
2010/04
熊本大学　グローバルCOE リサーチ・アソシエイト
2012/04
熊本大学　発生医学研究所　博士研究員
2013/04
大阪大学大学院　基礎工学研究科　特任研究員
2014/04
熊本大学　発生医学研究所　博士研究員
2017/04
大阪大学大学院　基礎工学研究科　特任助教
2017/09
大阪大学大学院　工学研究科　特任助教
2018/10
大阪大学ナノサイエンスデザイン教育研究センター　特任助教
2022/04
東京農工大学　工学研究院　生命工学専攻　特任助教
2024/05
神戸大学　先端バイオ工学研究センター　特命助教

受賞等

  • 2022/06　日本蛋白質科学会　若手奨励賞
  • 2017/10　The 38th Symposium on UltraSonic Electronics (USE2017) 奨励賞
  • 2015/11　公益財団法人 肥後医育振興会 学術奨励賞
  • 2011/11　2011年度 特定領域「タンパク質の社会」全体班会議 ポスター賞 優秀賞
  • 2011/11　9th International Conference on AAA Proteinsポスター賞

発表論文

  1. Takatsu, M., Morihiro, K., Watanabe, H., Yuki, M., Hattori, Noi, K., Aikawa, K., Noguchi, K., Yohda, M., Okazoe, T., Okamoto, A. (2023/11) Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery, ACS Chemical Biology, 18(12), 2590-2598
  2. Cai, X., Ito, S., Noi, K., Kato, Y., Nagata, K., Inaba, K. (2023/11) Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP, The Journal of Biochemistry, 299(11), 105274
  3. Noi, K., Nakajima, K., Yamaguchi, K., So, M., Ikenaka, K., Mochizuki, H., Goto, Y., Ogi, H. (2022/03) Acceleration of amyloid fibril formation by multichannel sonochemical reactor, Japanese Journal of Applied Physics, 61, SG1002
  4. Noi, K., Ikenaka, K., Mochizuki, H., Goto, Y., Ogi, H. (2021/08) Disaggregation behavior of amyloid β fibrils by anthocyanins studied by total-internal-reflection-fluorescence microscopy coupled with a wireless quartz-crystal microbalance biosensor, Analytical Chemisyry, 93(32), 11176-11183
  5. Inoue, Y., Hanazono, Y., Noi, K., Kawamot, A., Kimatsuka, M., Harada, R., Takeda, K., Kita, R., Iwamasa, N., Shibata, K., Noguchi, K., Shigeta, Y., Namba, K., Ogura, T., Miki, K., Shinohara, K., Yohda, M. (2021/07) Split conformation of Chaetomium thermophilum Hsp104 disaggregase, Structure, 29(7), 721-730
  6. Saito, T., Matunaga, D., Matsui, TS., Noi, K., Deguchi, S. (2021/07) Determining the domain-level reaction-diffusion properties of an actin-binding protein transgelin-2 within cells, Experimental Cell Research, 404, 112619
  7. Nakajima, K., Noi, K., Yamaguchi, K., So, M., Ikenaka, K., Mochizuki, H., Ogi, H., Goto, Y. (2021/05) Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation, Ultrasonics Sonochemistry, 73, 105508
  8. Hirayama, C., Machida, K., Noi, K., Murakawa, T., Okumura, M., Ogura, T., Imataka, H., Inaba, K. (2021/04) Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation, iScience, 24(4), 102296
  9. Noi, K., Iijima, M., Kuroda, S., Kato, F., Ogi, H. (2020/03) Mechanism of affinity enhanced protein adsorption on bio-nanocapsules studied by viscoelasticity measurement with wireless QCM biosensor, Japanese Journal of Applied Physics, 59, KKB03
  10. Noi, K., Iijima, M., Kuroda, S., Ogi, H. (2019/08) Ultrahigh-Sensitive Wireless QCM with Bio-nanocapsules, Sensors and Actuators B: Chemical, 293, 59-62
  11. Noi, K., Iwata, A., Kato, F., Ogi, H. (2019/07) Ultrahigh-Frequency Wireless MEMS QCM Biosensor for Direct Label-Free Detection of Biomarkers in a Large Amount of Contaminants, Analytical Chemistry, 91(15), 9398-9402
  12. Yamauchi, S., Kobashigawa, Y., Fukuda, N., Teramoto, M., Toyota, Y., Liu, C., Ikeguchi, Y., Sato, T., Sato, Y., Kimura, H., Masuda, T., Ohtsuki, S., Noi, K., Ogura, T., Morioka, H. (2019/07) Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Lnter-Chain VH-VL Interactions, Molecules, 24, 2620
  13. Okumura, M., Noi, K., Kanemura, S., Kinoshita, M., Saio, T., Inoue, Y., Hikima, T., Akiyama, S., Ogura, T., Inaba, K. (2019/04) Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding, Nature Chemical Biology, 15, 499-509
  14. Kakuda, K., Ikenaka, K., Araki, K., So, M., Aguirre, C., Kajiyama, Y., Konaka, K., Noi, K., Baba, K., Tsuda, H., Nagano, S., Ohmichi, T., Nagai, Y., Tokuda, T., El-Agnaf, O.M.A., Ogi, H., Goto, Y., Mochizuki, H. (2019/04) Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid, Scientific Reports, 9, 6001
  15. Niwa, H., Miyauchi-Nanri, Y., Omoto, K., Mukai, S., Noi, K., Ogura, T., Fujiki, Y. (2018/12) A newly isoloated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein, The Journal of Biochemistry, 164(6), 437-447
  16. Morita, K., Yamamoto, YY., Hori, A., Obata, T., Uno, Y., Shinohara, K., Noguchi, K., Noi, K., Ogura, T., Ishii, K., Kato, K., Kikumoto, M., Arranz, R., Valouesta, J.M., Yohda, M. (2018/08) Expression, functional characterization, and preliminary crystallization of the cochaperone prefoldin from the thermophilic fungus Chaetomium thermophilum, International Journal of Molecular Sciences, 19(8), E2452
  17. Lai, Y-T., Ogi, H., Noi, K., Kato, F. (2018/04) Viscoelasticity response during fibrillation of amyloid β peptides on quartz crystal microbalance biosensor, Langmuir, 34, 5474-5479
  18. Fukuda, N., Noi, K., Weng, L., Kobashigawa, Y., Miyazaki, H., Wakeyama, Y., Takaki, M., Nakahara, Y., Tatsuno, Y., Uchida-Kamekura, M., Suwa, Y., Sato, T., Ichikawa-Tomikawa, N., Nomizu, M., Fujiwara, Y., Ohsaka, F., Saitoh, T., Maenaka, K., Kumeta, H., Shinya, S., Kojima, C., Ogura, T., Morioka, H. (2017/10) Production of Single-Chain Fv Antibodies Specific for GA-pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion, Molecules, 22(10), 1695
  19. Yamato, M., Matsuzaki, T., Araki, R., Tsuchida, S., Okuda, K., Ying, H., Sanada, S., Asanuma, H., Asano, Y., Asakura, M., Torii, H., Noi, K., Ogi, H., Iwamoto, R., Mekada, E., Takashima, S., Kitakaze, M., Sakata, Y., Minamino, T. (2017/09) RNA aptamer binds heparin-binding epidermal growth factor-like growth factor with high affinity and specificity and neutralizes its activity, International Journal of Gerontology, 11, 191-196
  20. Maegawa, K., Watanabe, S., Noi, K., Okumura, M., Amagai, Y., Inoue, M., Ushioda, R., Nagata, K., Ogura, T., Inaba, K. (2017/06) The highly dynamic　nature　of　ERdj5　is　key　to　efficient　elimination　of　aberrant　protein　oligomers　through　ER-associated degradation, Structure, 25(6), 846-857
  21. Yamamoto, D., Noi, K., Ogura, T. (2017/03) A substrate for observing histidine-tagged proteins by high-speed atomic force microscopy, Fukuoka University Science Reports, 47(1), 1-6
  22. Nakajima, K., Ogi, H., Adachi, K., Noi, K., Hirao, M., Yagi, H., Goto, Y. (2016/02) Nucleus factory on cavitation bubble for amyloid β fibril, Scientific Reports, 6, 22015
  23. Hamada, H., Ogi, H., Noi, K., Yagi, H., Goto, Y., Hirao, M. (2015/05) Nucleation-fibrillation dynamics of Aβ1-40 peptides on liquid-solid surface studied by total-internal-reflection fluorescence microscopy coupled with quartz-crystal microbalance biosensor, Japanese Journal of Applied Physics, 54, 07HE01
  24. Johjima, A., Noi, K., Nishikori, S., Ogi, H., Esaki, M., Ogura, T. (2015/05) Microtubule severing by katanin p60 AAA+ ATPase requires the C-terminal acidic tails of both α- and β-tubulins and basic amino acid residues in the AAA+ ring pore, The Journal of Biochemistry, 290(18), 11762-11770
  25. Ogi, H., Fukushima, M., Hamada, H., Noi, K., Hirao, M., Yagi, H., Goto, Y. (2014/11) Ultrafast propagation of β-amyloid fibrils in oligomeric cloud, Scientific Reports, 4, 6960
  26. Noi, K., Yamamoto, D., Nishikori, S., Arita-Morioka, K., Kato, T., Ando, T., Ogura, T. (2013/11) High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97, Structure, 21(10), 1992-2002
  27. Noi, K., Kitamura, A., Hirai, H., Hongo, K., Sakurai, T., Mizobata, T., Kawata, Y. (2012/07) Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma acidophilum, American Journal of Respiratory Cell and Molecular Biology, 2(3), 265-275
  28. Noi, K., Hirai, H., Hongo, K., Mizobata, T., Kawata, Y. (2009/10) A potentially versatile nucleotide hydrolysis activity of group II chaperonin monomers from Thermoplasma acidophilum, Biochemistry, 48(40), 9405-9415
  29. Hirai, H., Noi, K., Hongo, K., Mizobata, T., Kawata, Y. (2008/04) Functional characterization of the recombinant group II chaperonin alpha from Thermoplasma acidophilum, The Journal of Biochemistry, 143(4), 505-515

総説・解説等

  1. 野井 健太郎, 荻 博次, 無線QCM粘弾性計測によるBNC上の蛋白質捕捉時の親和性向上機構の解析, 超音波テクノ, 33(5) (2021)
  2. Okumura, M., Noi, K., Inaba, K. Visualization of structural dynamics of protein disulfide isomerase enzymes in catalysis of oxidative folding and reductive unfolding, Current Oppnion in Structural Biology, 66, 49-57 (2021)