メンバー紹介

TOP メンバー（先端バイオ） 光延　仁志

特命准教授光延　仁志 Hitoshi　Mitsunobu

経歴

2005/03
九州大学　農学部　生物資源環境学科　卒業
2007/03
九州大学大学院　生物資源環境科学府　博士課程前期課程　生物資源開発管理学専攻　修了
2007/04
日本学術振興会特別研究員（DC1）
2009/12
ハーバード大学　医学部博士研究員（Charles Richardson Lab）
2010/03
九州大学大学院　生物資源環境科学府　博士課程後期 課程　生物資源開発管理学専攻　修了
2016/07
神戸大学　イノベーション研究科　特命助教
2021/04
株式会社バイオパレット　主任研究員
2023/06
神戸大学　先端バイオ工学研究センター　特命准教授

受賞等

  • 2006年　ハート昆虫研究奨励基金　優秀賞
　

発表論文

  1. Mitsunobu, H., Kita, Y., Nambu-Nishida, Y., Miyazaki, S., Nakajima, K., Taoka, K., Kondo, A., Nishida, K. (2025/4) Development of a highly efficient base editing system for Lactobacilli to improve probiotics and dissect essential functions Applied Microbiology and Biotechnology, 109(1), 96
  2. Li, A., Mitsunobu, H., Yoshioka, S., Suzuki, T., Kondo, A., Nishida, K. (2022/8) Cytosine base editing systems with minimized off-target effect and molecular size. Nat Commun., 13(1):4531
  3. Katayama, K., Mitsunobu, H., Nishida, K. (2019/10) Mammalian synthetic biology by CRISPRs engineering and applications, Current Opinion in Chemical Biology 52 79-84
  4. Banno S., Nishida K., Arazoe T., Mitsunobu H., Kondo A. (2018/2) Deaminase-mediated multiplex genome editing in Escherichia coli, Nature Microbiology, 3(4):423-429
  5. Mitsunobu, H., Teramoto, J., Nishida, K., Kondo, A. (2017/10) Beyond Native Cas9: Manipulating Genomic Information and Function. Trends Biotechnol., 35(10):983-996
  6. Zhu, B., Wang, L., Mitsunobu, H., Lu, X., Hernandez, A. J., Yoshida-Takashima, Y., Nunoura, T., Tabor, S., Richardson, C. C. (2017/2) Deep-sea vent phage DNA polymerase specifically initiates DNA synthesis in the absence of primers, Proc Natl Acad Sci U S A., 114(12):E2310-E2318
  7. Li, Z., Mon H., Mitsunobu, H., Zhu, L., Xu, J., Lee, J. M., Kusakabe, T. (2014/12) Dynamics of polycomb proteins-mediated histone modifications during UV irradiation-induced DNA damage. Insect Biochem Mol Biol, 55, 9-18
  8. Mitsunobu, H., Zhu, B., Lee, S. J., Tabor, S., Richardson, C. C. (2014/3) Flap endonuclease of bacteriophage T7: Possible roles in RNA primer removal, recombination and host DNA breakdown. Bacteriophage, 4, e28507
  9. Tatsuke, T., Zhu, L., Li, Z., Mitsunobu, H., Yoshimura, K., Mon, H., Lee, J. M., Kusakabe, T. (2014/2) Roles of Piwi proteins in transcriptional regulation mediated by HP1s in cultured silkworm cells. PLoS One, 9(3), e92313
  10. Mitsunobu, H., Zhu, B., Lee, S. J., Tabor, S., Richardson, C. C. (2014) Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7. J Biol Chem, 289(9), 5860-75
  11. Lee, J. M., Kawakami, N., Mon, H., Mitsunobu, H., Iiyama, K., Ninaki, S., Maenaka, K., Park, E. Y., Kusakabe, T. (2012/6,10) Establishment of a Bombyx mori nucleopolyhedrovirus (BmNPV) hyper-sensitive cell line from the silkworm e21 strain. Biotechnol Lett., 34(10), 1773-9
  12. Mitsunobu, H., Izumi, M., Mon, H., Tatsuke, T., Lee, J. M., Kusakabe, T. (2011/12) Molecular characterization of heterochromatin proteins 1a and 1b from the silkworm, Bombyx mori. Insect Mol Biol., 21(1), 9-20
  13. Mon, H., Izumi, M., Mitsunobu, H., Tatsuke, T., Iiyama, K., Jikuya, H., Lee, J. M., Kusakabe, T. (2011/11) Post-translational modifications of the N-terminal tail of histone H3 in holocentric chromosomes of Bombyx mori. Insect Biochem Mol Biol., 41(11), 902-8
  14. Hong, S. M., Yamashita, J., Mitsunobu, H., Uchino, K., Kobayashi, I., Sezutsu, H., Tamura, T., Nakajima, H., Miyagawa, Y., Lee, J., Mon, H., Miyata, Y., Kawaguchi, Y., Kusakabe, T. (2010/5) Efficient soluble protein production on transgenic silkworms expressing cytoplasmic chaperones. Appl Microbiol Biotechnol., 87(6), 2147-56
  15. Mitsunobu, H., Izumi, M., Iiyama, K., Jikuya, H., Lee, J. M., Mon, H., Kawaguchi, Y., Kusakabe, T. (2010/5) Molecular characterization of core histones in the silkworm, Bombyx mori. J. Insect Biotech Seric., 79, 75-83
  16. Hong, S. M., Noh, S. K., Kim, K. A., Mitsunobu, H., Mon, H., Lee, J. M., Kawaguchi, Y., Kusakabe, T. (2009/5) Molecular characterization, localization, and distribution of innexins in the silkworm, Bombyx mori. Mol Biotechnol., 43(1), 52-8
  17. Lee, J., Takahashi, M., Mon, H., Mitsunobu, H., Koga, K., Kawaguchi, Y., Nakajima, Y., Kusakabe, T. (2007/8) Construction of gene expression systems in insect cell lines using promoters from the silkworm, Bombyx mori. J Biotechnol., 133(1), 9-17
  18. Sugahara, R., Mon, H., Yamashita, J., Mitsunobu, H., Lee, J., Kawaguchi, Y., Koga, K., and Kusakabe, T. (2007) Heterotrimeric complex of replication protein A, a single-stranded DNA binding protein, from the silkworm, Bombyx mori., J Insect Biotec Seric., 76, 129-135
  19. Yamashita, J., Miyagawa, Y., Sugahara, R., Mon, H., Mitsunobu, H., Lee, J. M., Kawaguchi, Y., and Kusakabe, T. (2007/10) Molecular cloning of silkworm Cdc37 and its interaction with Hsp90 chaperon. ,J Insect Biotech Seric., 76, 137-143
  20. Mitsunobu, H., Sakashita, K., Mon, H., Lee, J. M., Kawaguchi, Y., Koga, K., Kusakabe, T. (2006/10) Construction of gateway-based destination vectors for detecting subcellular localization of proteins in the silkworm, Bombyx mori. J Insect Biotech Seric., 75, 141-6.10.

著書

  1. 最新のゲノム編集技術と用途展開　第5章, 大西美和, 光延仁志, 西田敬二　CMC 出版　(2021/2)
  2. ゲノム編集技術を応用した製品開発とその実用化～研究開発動向・課題解決策・技術予測と市場展望 　第3章 5節, Li Ang, 光延仁志, 西田敬二　技術情報協会　(2021/2)
  3. 遺伝子医学 34 号　Main theme 2, 光延仁志, 西田敬二　メディカル ドゥ　(2020/10)