メンバー紹介

特命助教光延 仁志 Hitoshi Mitsunobu

経歴

2005/03
九州大学 農学部 生物資源環境学科 卒業
2007/03
九州大学大学院 生物資源環境科学府生物資源開発管理学専攻博士前期課程 修了
2010/03
九州大学大学院 生物資源環境科学府生物資源開発管理学専攻博士後期課程 修了
博士(農学)
2009/12
ハーバード大学医学部 博士研究員
2016/07
神戸大学大学院 科学技術イノベーション研究科 特命助教

受賞等

  • 2006/12 ハート昆虫研究奨励基金 優秀賞

発表論文

  1. Banno, S., Nishida, K., Arazoe, T., Mitsunobu, H., Kondo, A. (2018) Deaminase-mediated multiplex genome editing in Escherichia coli, Nature Microbiology, 3, 423-429
  2. Mitsunobu, H., Teramoto, J., Nishida, K., Kondo, A. (Review)(2017) Beyond native Cas9: manipulating genomic information and function, Trends in Biotechnology, 35(10), 983-996
  3. Li, Z., Mon, H., Mitsunobu, H., Zhu, L., Xu, J., Lee, J. M., Kusakabe, T. Dynamics of polycomb proteins-mediated histone modifications during UV irradiation-induced DNA damage. Insect Biochemistry and Molecular Biology, 55, 9-18 (2014)
  4. Mitsunobu, H., Zhu, B., Lee, S. J., Tabor, S., Richardson, C. C. Flap endonuclease of bacteriophage T7: Possible roles in RNA primer removal, recombination and host DNA breakdown. Bacteriophage, 4, e28507 (2014)
  5. Tatsuke, T., Zhu, L., Li, Z., Mitsunobu, H., Yoshimura, K., Mon, H., Lee, J. M., Kusakabe, T., Roles of Piwi proteins in transcriptional regulation mediated by HP1s in cultured silkworm cells. PLoS One, 9(3), e92313 (2014)
  6. Mitsunobu, H., Zhu, B., Lee, S. J., Tabor, S., Richardson, C. C., Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7. The Journal of Biological Chemistry, 289(9), 5860-5875 (2014)
  7. Lee, J. M., Kawakami, N., Mon, H., Mitsunobu, H., Iiyama, K., Ninaki, S., Maenaka, K., Park, E. Y., Kusakabe, T. Establishment of a Bombyx mori nucleopolyhedrovirus (BmNPV) hyper-sensitive cell line from the silkworm e21 strain. Biotechnology Letters, 34(10), 1773-1779 (2012)
  8. Mitsunobu, H., Izumi, M., Mon, H., Tatsuke, T., Lee, J. M., Kusakabe, T. Molecular characterization of heterochromatin proteins 1a and 1b from the silkworm, Bombyx mori. Insect Molecular Biology, 21(1), 9-20 (2011)
  9. Mon, H., Izumi, M., Mitsunobu, H., Tatsuke, T., Iiyama, K., Jikuya, H., Lee, J. M., Kusakabe, T. Post-translational modifications of the N-terminal tail of histone H3 in holocentric chromosomes of Bombyx mori. Insect Biochemistry and Molecular Biology, 41(11), 902-908 (2011)
  10. Hong, S. M., Yamashita, J., Mitsunobu, H., Uchino, K., Kobayashi, I., Sezutsu, H., Tamura, T., Nakajima, H., Miyagawa, Y., Lee, J., Mon, H., Miyata, Y., Kawaguchi, Y., Kusakabe, T. Efficient soluble protein production on transgenic silkworms expressing cytoplasmic chaperones. Applied Microbiology and Biotechnology, 87(6), 2147-2156 (2010)
  11. Mitsunobu, H., Izumi, M., Iiyama, K., Jikuya, H., Lee, J. M., Mon, H., Kawaguchi, Y., Kusakabe, T. Molecular characterization of core histones in the silkworm, Bombyx mori. Journal of Insect Biotechnology and Sericology, 79, 75-83 (2010)
  12. Hong, S. M., Noh, S. K., Kim, K. A., Mitsunobu, H., Mon, H., Lee, J. M., Kawaguchi, Y., Kusakabe, T.  Molecular characterization, localization, and distribution of innexins in the silkworm, Bombyx mori. Molecular Biotechnology, 43(1), 52-58 (2009)
  13. Lee, J., Takahashi, M., Mon, H., Mitsunobu, H., Koga, K., Kawaguchi, Y., Nakajima, Y., Kusakabe, T. Construction of gene expression systems in insect cell lines using promoters from the silkworm, Bombyx mori. Journal of Biotechnology, 133(1), 9-17 (2007)
  14. Sugahara, R., Mon, H., Yamashita, J., Mitsunobu, H., Lee, J., Kawaguchi, Y., Koga, K., Kusakabe, T.  Heterotrimeric complex of replication protein A, a single-stranded DNA binding protein, from the silkworm, Bombyx mori. Journal of Insect Biotechnology and Sericology, 76, 129-135 (2007)
  15. Yamashita, J., Miyagawa, Y., Sugahara, R., Mon, H., Mitsunobu, H., Lee, J. M., Kawaguchi, Y.,  Kusakabe, T.  Molecular cloning of silkworm Cdc37 and its interaction with Hsp90 chaperon. Journal of Insect Biotechnology and Sericology, 76, 137-143 (2007)
  16. Mitsunobu, H., Sakashita, K., Mon, H., Lee, J. M., Kawaguchi, Y., Koga, K., Kusakabe, T. Construction of gateway-based destination vectors for detecting subcellular localization of proteins in the silkworm, Bombyx mori. Journal of Insect Biotechnology and Sericology, 75, 141-146 (2006)