TOP メンバー(先端バイオ) 秀瀬 涼太
経歴
- 2005/03
- 大分大学 工学部 応用化学科 卒業
- 2005/04
- 京都大学 化学研究所 研究生 (2006年3月まで)
- 2008/03
- 京都大学 大学院 農学研究科 修士課程応用生命科学専攻 修了
- 2009/04
- 日本学術振興会 特別研究員(研究職) (2011年3月まで)
- 2010/03
- 日本学術振興会 優秀若手研究者海外派遣事業(派遣先:ウィスコンシン大学マディソン校) 特別研究員 (2010年9月まで)
- 2011/03
- 京都大学 大学院 農学研究科 博士後期課程応用生命科学専攻 修了
- 2011/04
- 関西学院大学 大学院 理工学研究科 生命環境科学研究センター 博士研究員 (2014年3月まで)
- 2014/04
- マックスプランク陸生微生物学研究所 博士研究員 (2015年3月まで)
- 2015/04
- 関西学院大学 理工学部生命科学科 助教 (2018年3月まで)
- 2018/04
- 神戸大学 大学院 科学技術イノベーション研究科 特命准教授
- 2021/03
- 神戸大学 先端バイオ工学研究センター 配置(兼任)
- 2023/04
- 株式会社バッカス・バイオイノベーション 研究チーム チーフ(6月より マネジャーに呼称変更)
- 2023/12
- 神戸大学 先端バイオ工学研究センター 特命准教授
受賞等
- 2019 日本生物工学会 2019年度(第27回)生物工学論文賞
- 2018 極限環境生物学会 研究奨励賞
- 2018 平成30年度 長瀬研究振興賞
- 2018 日本生物工学会 2018年度(第26回)生物工学論文賞
発表論文
- Hidese, R., Ohbayashi, R., Kato, Y., Matsuda, M., Tanaka, K., Imamura, S., Ashida, H., Kondo, A., Hasunuma, T. (2023/12) ppGpp accumulation reduces the expression of the global nitrogen homeostasis-modulating NtcA regulon by affecting 2-oxoglutarate levels, Communications Biology, 6, 1285
- Hidese, R., Matsuda, M., Kajikawa, M., Osanai, T., Kondo, A., Hasunuma, T. (2022/11) Metabolic and microbial community engineering for four-carbon dicarboxylic acid production from CO2-derived glycogen in the Cyanobacterium Synechocystis sp. PCC6803, ACS Synthetic Biology, 11, 4054-4064
- Oyama, T., Kato, Y., Hidese, R., Matsuda, M., Matsutani, M., Watanabe, S., Kondo, A., Hasunuma, T. (2022/09) Development of a stable semi-continuous lipid production system of an oleaginous Chlamydomonas sp. mutant using multi-omics profiling, Biotechnology for Biofuels and Bioproducts, 15, 95
- Kato, Y., Inabe, K., Hidese, R., Kondo, A., Hasunuma, T. (2022/01) Metabolomics-based engineering for biofuel and bio-based chemical production in microalgae and cyanobacteria: A review, Bioresource Technology, 344(A): 126196
- Inabe, K., Miichi, A., Matsuda, M., Yoshida, T., Kato, Y., Hidese, R., Kondo, A., Hasunuma, T. (2021/12) Nitrogen availability affects the metabolic profile in Cyanobacteria, Metabolites, 11, 867
- Kato, Y., Oyama, T., Inokuma, K., Vavricka, CJ., Matsuda, M., Hidese, R., Satoh, K., Oono, Y., Chang, JS., Hasunuma, T., Kondo, A. (2021/04) Enhancing carbohydrate repartitioning into lipid and carotenoid by disruption of microalgae starch debranching enzyme, Communications Biology, 4: 450
- Fukuda, W., Yamori, Y., Hamakawa, M., Osaki, M., Fukuda, M., Hidese, R., Kanesaki, Y., Okamoto-Kainum, A., Kato, S., Fujiwara, S. (2020/02) Genes regulated by branched-chain polyamine in the hyperthermophilic archaeon Thermococcus kodakarensis, Amino Acids, 52, 287-299
- Hidese, R.#, Matsuda, M.#, Osanai, T., Hasunuma, T.*, Kondo, A. (2020/01) Malic enzyme facilitates D-lactate production through increased pyruvate supply during anoxic dark fermentation in Synechocystis sp. PCC 6803, ACS Synthetic Biology, 9, 260-268
# equally contributed authors - Hidese, R., Toyoda, M., Yoshino, KI., Fukuda, W., Wihardja, GA., Kimura, S., Fujita, J., Niitsu, M., Oshima, T., Imanaka, T., Mizohata, E., Fujiwara, S. (2019/10) The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis. The FEBS Journal, 286(19), 3926-3940
- Yamori, Y., Hamakawa, M., Hidese, R., Fukuda, M., Atomi, H., Fukuda, W., Fujiwara, S. (2019/05) Branched-chain polyamine stabilizes RNA polymerase at elevated temperatures in hyperthermophiles. Amino Acids, 1-11
- Sakihama, Y., Hidese, R., Hasunuma, T., Kondo, A. (2019/03) Increased flux in acetyl-CoA synthetic pathway and TCA cycle of Kluyveromyces marxianus under respiratory conditions. Scientific Reports, 9(1): 5319
- Okano, H., Baba, M., Hidese, R., Iida, K., Li, T., Kojima, K., Takita, T., Yanagihara, I., Fujiwara, S., Yasukawa, K. (2018/08) Accurate fidelity analysis of the reverse transcriptase by a modified next-generation sequencing. Enzyme Microb Technol, 115: 81-85
- Akasaka, N., Kato, S., Kato, S., Hidese, R., Wagu, Y., Sakoda, H., Fujiwara, S. (2018/07) Agmatine Production by Aspergillus oryzae Is Elevated by Low pH during Solid-State Cultivation. Appl Environ Microbiol, 17; 84(15)
- Okano, H., Baba, M., Kawato, K., Hidese, R., Yanagihara, I., Kojima, K., Takita, T., Fujiwara, S., Yasukawa, K. (2018/03) High sensitive RNA detection by one-step RT-PCR using the genetically engineered variant of DNA polymerase with reverse transcriptase activity from hyperthermophilies, Journal of Bioscience and Bioengineering, 125(3), 275-281
- Hidese, R., Kawato, K., Nakura, Y., Yasukawa, K., Yanagihara, I., Fujiwara, S. (2018/01) Thermostable DNA helicase improves the sensitivity of digital PCR, Biochemical and Biophysical Research Communications, 495(3), 2189-2194
- Ishii, Y., Akasaka, N., Sakoda, H., Hidese, R., Fujiwara, S. (2018/01) Leucine responsive regulatory protein is involved in methionine metabolism and polyamine homeostasis in acetic acid bacterium Komagataeibacter europaeus, Journal of Bioscience and Bioengineering, 125(1), 67-75
- Hidese, R., Tse, KM., Kimura, S., Mizohata, E., Fujita, J., Horai, Y., Umezawa, N., Higuchi, T., Niitsu, M., Oshima, T., Imanaka, T., Inoue, T., Fujiwara, S. (2017/11) Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine. The FEBS Journal, 284(21), 3684-3701
- Yasukawa, K., Iida, K., Okano, H., Hidese, R., Baba, M., Yanagihara, I., Kojima, K., Takita, T., Fujiwara, S. (2017/10) Next-generation sequencing-based analysis of reverse transcriptase fidelity. Biochemical and Biophysical Research Communications, 492(2): 147-153
- Hidese, R., Yamashita, K., Kawazuma, K., Kanai, T., Atomi, H., Imanaka, T., Fujiwara, S. (2017/09) Gene regulation of two ferredoxin:NADP+ oxidoreductases by the redox-responsive regulator SurR in Thermococcus kodakarensis, Extremophiles, 21(5): 903-917
- Gao, L., Hidese, R., Fujiwara, S. (2017/09) Function of a thermophilic archaeal chaperonin is enhanced by electrostatic interactions with its targets, Journal of Bioscience and Bioengineering, 124(3): 283-288
- Hidese, R., Im, KH., Kobayashi, M., Niitsu, M., Furuchi, T., Fujiwara, S. (2017/07) Identification of a novel acetylated form of branched-chain polyamine from a hyperthermophilic archaeon Thermococcus kodakarensis, Bioscience, Biotechnology, and Biochemistry, 81(9): 1845-1849
- Okano, H., Baba, M., Yamasaki, T., Hidese, R., Fujiwara, S., Yanagihara, I., Ujiiye, T., Hayashi, T., Kojima, K., Takita, T., Yasukawa, K. (2017/05) High sensitive one-step RT-PCR using MMLV reverse transcriptase, DNA polymerase with reverse transcriptase activity, and DNA/RNA helicase, Biochemical and Biophysical Research Communications, 487(1): 128-133
- Okano, H., Katano, Y., Baba, M., Fujiwara, A., Hidese, R., Fujiwara, S., Yanagihara, I., Hayashi, T., Kojima, K., Takita, T., Yasukawa, K. (2017/01) Enhanced detection of RNA by MMLV reverse transcriptase coupled with termostable DNA polymerase and DNA/RNA helicase, Enzyme and Microbial Technology, 96: 111-120
- Fujiwara, A., Kawato, K., Kato, S., Yasukawa, K., Hidese, R., Fujiwara, S. (2016/05) Application of a Euryarchaeota-Specific Helicase from Thermococcus kodakarensis for Noise Reduction in PCR, Applied and Environmental Microbiology, 82(10): 3022-3031
- Hidese, R., Ataka, K., Bill, E., Shima, S. (2015/07) CuI and H2O2 Inactivate and FeII Inhibits [Fe]-Hydrogenase at very low Concentrations, ChemBioChem, 16(13): 1861-1865
- Akasaka, N., Astuti, W., Ishii, Y., Hidese, R., Sakoda, H., Fujiwara, S. (2015/06) Change in the plasmid copy number in acetic acid bacteria in response to growth phase and acetic acid concentration, Journal of Bioscience and Bioengineering, 119(6): 661-668
- Akasaka, N., Ishii, Y., Hidese, R., Sakoda, H., Fujiwara, S. (2014/12) Enhanced production of branched-chain amino acids by Gluconacetobacter europaeus with a specific regional deletion in a leucine responsive regulator, Journal of Bioscience and Bioengineering, 118(6): 607-615
- Hidese, R., Inoue, T., Imanaka, T., Fujiwara, S. (2014/07) Cysteine desulphurase plays an important role in environmental adaptation of the hyperthermophilic archaeon Thermococcus kodakarensis, Molecular Microbiology, 93(2): 331-345
- Okada, K., Hidese, R., Fukuda, W., Niitsu, M., Takao, K., Horai, Y., Umezawa, N., Higuchi, T., Oshima, T., Yoshikawa, Y., Imanaka, T., Fujiwara, S. (2014/05) Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles, Journal of Bacteriology, 196(10): 1866-1876
- Hidese, R., Nishikawa, R., Gao, L., Katano, M., Imai, T., Kato, S., Kanai, T., Atomi, H., Imanaka, T., Fujiwara, S. (2014/05) Different roles of two transcription factor B proteins in the hyperthermophilic archaeon Thermococcus kodakarensis, Extremophiles, 18(3): 573-588
- Hidese, R., Mihara, H., Kurihara, T., Esaki, N. (2014/03) Global identification of genes affecting iron-sulfur cluster biogenesis and iron homeostasis, Journal of Bacteriology, 196(6):1238-1249
- Akasaka, N., Sakoda, H., Hidese, R., Ishii, Y., Fujiwara, S. (2013/12) An efficient method using Gluconacetobacter europaeus to reduce an unfavorable flavor compound, acetoin, in rice vinegar production, Applied and Environmental Microbiology, 79(23): 7334-7342
- Nagaoka, E., Hidese, R., Imanaka, T., Fujiwara, S. (2013/08) Importance and determinants of induction of cold-induced DEAD RNA helicase in the hyperthermophilic archaeon Thermococcus kodakarensis, Journal of Bacteriology, 195(15): 3442-3450
- Hidese, R., Mihara, H., Kurihara, T., Esaki, N. (2012/10) Pseudomonas putida PydR, a RutR-like transcriptional regulator, represses the dihydropyrimidine dehydrogenase gene in the pyrimidine reductive catabolic pathway, Journal of Biochemistry, 152(4): 341-346
- Hidese, R., Mihara, H., Esaki, N. (2011/07) Bacterial cysteine desulfurases: versatile key players in biosynthetic pathways of sulfur-containing biofactors, Applied Microbiology and Biotechnology, 91(1): 47-61
- Hidese, R., Mihara, H., Kurihara, T., Esaki, N. (2011/02) Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil, Journal of Bacteriology, 193(4): 989-993
- Hidese, R., Mihara, H., Esaki, N. (2009/09) Functional analysis of a novel NADH-dependent dihydropyrimidine dehydrogenase from Escherichia coli, Vitamins (Japan), 83(9): 528-532
- Mihara, H., Hidese, R., Yamane, M., Kurihara, T., Esaki, N. (2008/08) The iscS gene deficiency affects the expression of pyrimidine metabolism genes, Biochemical and Biophysical Research Communications, 372(3): 407-411
総説・解説等
- 近藤昭彦, 蓮沼誠久, 秀瀬涼太, 育種技術 -突然変異から代謝工学へ-, 日本生物工学会100年史, 第3章 生物工学の研究100年, 29-31 (2022/10)
- 蓮沼誠久, 秀瀬涼太, 番場崇弘, [特集]「生物機能を利用したモノづくり」に貢献するプロセス強化 微生物の高速育種を実現するスマートセル創出プラットフォーム, 化学工学, 86(4), 157-160 (表紙採用) (2022/04)
- 加藤悠一, 秀瀬涼太, 蓮沼誠久, 特集 藻類バイオマス利用のための新しい生物工学(後半), 光合成メタボロミクスの物質生産への応用, 生物工学会誌, 99(9), 456-460 (2021/09)
- 藤原伸介, 藤原綾子, 秀瀬涼太, 耐熱性ヘリカーゼを利用した高精度核酸検出技術の開発, 生物工学会誌, 95(7): 383-387 (2017/07)
- 秀瀬涼太, 藤原伸介, 超好熱性アーキアThermococcus kodakarensis由来分岐鎖ポリアミン合成酵素の構造と機能, 酵素工学ニュース, 75 (2016/04)
- 秀瀬涼太, 進化は長い目で見て. 生物工学会誌, 94(3): 131 (2016/03)
- 秀瀬涼太, 藤原伸介, 好熱菌の低温ストレス耐性, 生物工学会誌, 93(8):464-467 (2015/08)
- 秀瀬涼太, 今岡進, 藤原伸介, 耐熱性タンパク質を利用したビスフェノールAの吸着, ケミカルエンジニアリング, 59(4): 17-21 (2014/04)
- 秀瀬涼太, 藤原伸介, 高温において翻訳活性化作用を持つポリアミン, バイオサイエンスとインダストリー, 70(3): 211-212 (2012/05)
- 秀瀬涼太, シャペロニンと生物進化, 生物工学会誌, 90(1): 39 (2012/01)
著書
- 秀瀬涼太, 蓮沼誠久. 水素酸化細菌によるCO2吸収, 第5章 CO2からの有用物質生産, 微生物を活用した有用物質の製造技術, シーエムシー出版, 170-179 (2023/05)
- 石井純, 西晶子, 北野美保, 中村朋美, 庄司信一郎, 秀瀬涼太, 蓮沼誠久, 近藤昭彦, 微生物を用いた物質生産とハイスループット微生物構築技術, スマートセルインダストリー -微生物細胞を用いた物質生産の展望-, 第1編 ハイスループット合成・分析・評価技術, 第2章 ハイスループット微生物構築・評価技術, 39-43, シーエムシー出版 (2018/06)
- Hidese, R., Fukuda, W., Niitsu, M., Fujiwara, S. Identification of branched-chain polyamines in hyperthermophiles, In Methods in Molecular Biology, Ruben Alcazar and Antonio F. Tiburcio (eds.). Heidelberg: Springer, pp. 81-94 (2018)
- Fujiwara, S., Hidese, R., Inoue, T., Fukuda, W. Protein synthesis and polyamines in thermophiles: Effect of polyamines on nucleic acid maintenance and gene expression, In Polyamines, a universal molecular nexus for growth, survival and specialized metabolism, Tomonobu Kusano and Hideyuki Suzuki (eds.). Heidelberg: Springer, pp. 143-152 (2015/11)
- Fukuda, W., Hidese, R., Fujiwara, S. Long-chain and branched polyamines in thermophilic microbes. In Polyamines, a universal molecular nexus for growth, survival and specialized metabolism, Tomonobu Kusano and Hideyuki Suzuki (eds.). Heidelberg: Springer, pp. 15-25 (2015)