TOP メンバー(先端バイオ) 番場 崇弘

経歴
- 2012/03
- 神戸大学 工学部 応用化学科 卒業
- 2014/03
- 神戸大学 大学院 工学研究科 応用化学専攻 博士課程前期 修了
- 2017/04
- 神戸大学 大学院 科学技術イノベーション研究科 学生研究支援員(研究職)
- 2018/03
- 神戸大学 大学院 工学研究科 応用化学専攻 博士課程後期 修了
- 2018/04
- 神戸大学 大学院 科学技術イノベーション研究科 学術研究員
- 2021/03
- 神戸大学 産官学連携本部 特命助教
- 2021/04
- 神戸大学 大学院 科学技術イノベーション研究科 特命助教
- 2022/04
- 先端バイオ工学推進機構 研究員
- 2022/10
- 神戸大学 先端バイオ工学研究センター 特命助教
- 2025/04
- 神戸大学 先端バイオ工学研究センター 特命准教授
発表論文
- Tanaka, K., Yukawa, T., Bamba T., Wakiya, M., Kumokita, R., Jin Y.S., Kondo, A., Hasunuma, T.*(2025/01) Engineering Saccharomyces cerevisiae for growth on xylose using an oxidative pathway, Applied Microbiology and Biotechnology, 109, 30
- Bamba, T., Munakata, R., Ushiro, Y., Kumokita, R., Tanaka, S., Hori, Y., Kondo, A., Yazaki, K., Hasunuma, T. (2024/12) De novo production of the bioactive phenylpropanoid artepillin C using membrane-bound prenyltransferase in Komagataella phaffii. ACS Synthetic Biology, 13(12):4040-4049
- Bamba, T., Aoki, R., Hori, Y., Ishikawa, S., Yoshida, KI., Taoka, N., Kobayashi, S., Yasueda, H., Kondo, A., Hasunuma, T. (2024/06) High-throughput evaluation of hemolytic activity through precise measurement of colony and hemolytic zone sizes of engineered Bacillus subtilis on blood agar, Biology Methods & Protocols, 9(1):bpae044
- Mori, H., Matsui, M., Bamba, T., Hori, Y., Kitamura, S., Toya, Y., Hidese, R., Yasueda, H., Hasunuma, T., Shimizu, H., Taoka, N., Kobayashi, S. (2024/07) Engineering Escherichia coli for efficient glutathione production, Metabolic engineering, 84, 180-190
- Tanaka, K., Bamba, T., Kondo, A., Hasunuma, T. (2024/02) Metabolomics-based development of bioproduction processes toward industrial-scale production. Current Opinion in Biotechnology, 85, 103057
- Kumokita, R., Bamba, T., Yasueda, H., Tsukida, A., Nakagawa, K., Kitagawa, T., Yoshioka, T., Matsuyama, H., Yamamoto, Y., Maruyama, S., Hayashi, T., Kondo, A., Hasunuma,T. (2024/02) High-level phenol bioproduction by engineered Pichia pastoris in glycerol fed-batch fermentation using an efficient pertraction system, Bioresource Technology, 393, 130144
- Yanagibashi, S., Bamba, T., Kirisako, T., Kondo, A., Hasunuma, T. (2024/01) The potency of mitochondria enlargement for mitochondria-mediated terpenoid production in yeast, Applied Microbiology and Biotechnology, 108: 110
- Yanagibashi, S., Bamba, T., Kirisako, T., Kondo, A., Hasunuma, T. (2024/01) Beneficial effect of optimizing the expression balance of the mevalonate pathway introduced into the mitochondria on terpenoid production in Saccharomyces cerevisiae, Journal of Bioscience and Bioengineering, 137(1): 16-23
- Bamba, T., Hori, Y., Umebayashi, K., Soh, C., Hakozaki, T., Toyama, K., Osumi, M., Kondo, A., Hasunuma, T. (2023/11) Comprehensive metabolic profiling of Geotrichum candidum and comparison with Saccharomyces cerevisiae, Journal of Bioscience and Bioengineering, 137(1): 9-15
- Inokuma, K., Miyamoto, S., Morinaga, K., Kobayashi, Y., Kumokita, R., Bamba, T., Ito, Y., Kondo, A., Hasunuma, T. (2023/04) Direct production of 4-hydroxybenzoic acid from cellulose using cellulase-displaying Pichia pastoris, Biotechnology and Bioengineering, 120(4): 1097-1107
- Yukawa, T., Bamba, T., Matsuda, M., Yoshida, T., Inokuma, K., Kim, J., Lee. J.W., Jin, Y.S., Kondo, A., Hasunuma, T. (2023/02) Enhanced production of 3,4-dihydroxybutyrate from xylose by engineered yeast via xylonate re-assimilation under alkaline condition, Biotechnology and Bioengineering, 120(2): 511-523
- Kumokita, R., Bamba, T., Inokuma, K., Yoshida, T., Ito, Y., Kondo, A., Hasunuma, T. (2022/05) Construction of an ʟ-Tyrosine chassis in Pichia pastoris enhances aromatic secondary metabolites production from glycerol, ACS Synthetic Biology, 11(6), 2098-2107
- Bamba, T.*, Guirimand, G.*, Kondo, A., Hasunuma, T. (2022/02) Enzyme display technology for lignocellulosic biomass valorization by yeast cell factories, Current Opinion in Green and Sustainable Chemistry, 33: 100584
- Inokuma, K., Kitada, Y., Bamba, T., Kobayashi, Y., Yukawa, T., den Haan, R., van Zyl, W. H., Kondo, A., Hasunuma, T. (2021/08) Improving the functionality of surface-engineered yeast cells by altering the cell wall morphology of the host strain, Applied Microbiology and Biotechnology ,105(14-15): 5895-5904
- Takenaka, M., Yoshida, T., Hori, Y., Bamba, T., Mochizuki, M., Vavricka, CJ., Hattori, T., Hayakawa, Y., Hasunuma, T.*, Kondo, A. (2021/01) An ion-pair free LC-MS/MS method for quantitative metabolite profiling of microbial bioproduction systems, Talanta, 222, 121625
- Yukawa, T., Bamba, T., Guirimand, G., Matsuda, M., Hasunuma, T.*, Kondo, A*. (2021/01) Optimization of 1,2,4-butanetriol production from xylose in Saccharomyces cerevisiae by metabolic engineering of NADH/NADPH balance, Biotechnology and Bioengineering, 118(1), 175-185
- Ito, Y., Terai, G., Ishigami, M., Hashiba, N., Nakamura, Y., Bamba, T., Kumokita, R., Hasunuma, T., Asai, K., Ishii, J.*, Kondo, A.* (2020/12) Exchange of endogenous and heterogeneous yeast terminators in Pichia pastoris to tune mRNA stability and gene expression, Nucleic Acids Research, 48(22), 13000-13012
- Bamba, T., Yukawa, T., Guirimand, G., Inokuma, K., Sasaki, K., Hasunuma, T., Kondo, A. (2019/12) Production of 1,2,4-butanetriol from xylose by Saccharomyces cerevisiae through Fe metabolic engineering, Metabolic Engineering, 56: 17-27
- Guirimand, GGY., Bamba, T., Matsuda, M., Inokuma, K., Morita, K., Kitada, Y., Kobayashi, Y., Yukawa, T., Sasaki, K., Ogino, C., Hasunuma, T., Kondo, A. (2019/09) Combined cell surface display of β-D-glucosidase (BGL), maltose transporter (MAL11) and overexpression of cytosolic xylose reductase (XR) in Saccharomyces cerevisiae enhance cellobiose/xylose coutilization for xylitol bio-production from lignocellulosic biomass, Biotechnology Journal, 14(9): e1800704 (9月号表紙採用)
- Guirimand, G., Inokuma, K., Bamba, T., Matsuda, M., Morita, K., Sasaki, K., Ogino, C., Berrin, JG., Hasunuma, T., Kondo, A. (2019/05) Cell-surface display technology and metabolic engineering of Saccharomyces cerevisiae for enhancing xylitol production from woody biomass, Green Chemistry, 21, 1795-1808
- Kobayashi, J., Sasaki, D., Bamba, T., Hasunuma, T., Kondo, A. (2019/02) Sustainable production of glutathione from lignocellulose-derived sugars using engineered Saccharomyces cerevisiae, Applied Microbiology and Biotechnology, 103(3), 1243-1254
- Bamba, T., Inokuma, K., Hasunuma, T., Kondo, A. (2018/03) Enhanced cell-surface display of a heterologous protein using SED1 anchoring system in SED1-disrupted Saccharomyces cerevisiae strain, Journal of Bioscience and Bioengineering, 125(3), 306-310
- Inokuma, K, Iwamoto, R., Bamba, T., Hasunuma, T., Kondo, A. (2017/12) Improvement of xylose fermentation ability under heat and acid co-stress in Saccharomyces cerevisiae using genome shuffling technique, Frontiers in Bioengineering and Biotechnology, 5: 81
- Mert, MJ., Rose, SH., la Grange, DC., Bamba, T., Hasunuma, T., Kondo, A., van Zyl, WH. (2017/10) Quantitative metabolomics of a xylose‑utilizing Saccharomyces cerevisiae strain expressing the Bacteroides thetaiotaomicron xylose isomerase on glucose and xylose, Journal of Industrial Microbiology and Biotechnology, 44(10), 1459-1470
- Inokuma, K., Bamba, T., Ishii, J., Ito, Y., Hasunuma, T., Kondo, A. (2016/11) Enhanced cell-surface display and secretory production of cellulolytic enzymes with Saccharomyces cerevisiae Sed1 signal peptide, Biotechnology and Bioengneering, 113(11): 2358-2366
- Guirimand, G., Sasaki, K., Inokuma, K., Bamba, T., Hasunuma, T., Kondo, A. (2016/04) Cell surface engineering of Saccharomyces cerevisiae combined with membrane separation technology for xylitol production from rice straw hydrolysate, Applied Microbiology Biotechnology, 100(8): 3477-3487
- Bamba, T., Hasunuma, T., Kondo, A. (2016/03) Disruption of PHO13 improves ethanol production via the xylose isomerase pathway, AMB Express, 6(1): 4
総説・解説等
- 番場崇弘, 棟方涼介, 矢﨑一史, 蓮沼誠久 プロポリス生理活性成分アルテピリンCの酵母による生産, バイオサイエンスとインダストリー(B&I), vol.83(3), 246-247 (2025/05)
- 蓮沼誠久, 秀瀬涼太, 番場崇弘, [特集]「生物機能を利用したモノづくり」に貢献するプロセス強化 微生物の高速育種を実現するスマートセル創出プラットフォーム, 化学工学, 86(4), 157-160 (表紙採用) (2022/04)
- 番場崇弘, 湯川貴弘, 蓮沼誠久, 鉄代謝改変酵母による1,2,4-ブタントリオール生産, バイオサイエンスとインダストリー(B&I), vol.78(2), 114-115 (2020/03)
- 番場崇弘, 猪熊健太郎, Gregory Guirimand, 蓮沼誠久, 細胞表層提示酵母を利用したクラフトパルプからのキシリトール生産, バイオサイエンスとインダストリー(B&I), vol.77(5), 390-392 (2019/09)