TOP メンバー(先端バイオ) 西田 敬二

経歴
- 2001/03
- 東京大学 理学部生物科学科 卒業
- 2003/03
- 東京大学大学院 理学系研究科 修士課程生物科学専攻修了
- 2003/04
- 日本学術振興会特別研究員(DC1)
- 2006/03
- 東京大学大学院 理学系研究科 博士課程生物科学専攻修了
- 2006/04
- 立教大学 理学部 博士研究員
- 2006/04
- 日本学術振興会特別研究員(PD)
- 2008/04
- ハーバード大学 医学部 博士研究員
- 2009/04
- 日本学術振興会海外特別研究員
- 2013/06
- 神戸大学 自然科学系先端融合研究環重点研究部 特命准教授
- 2016/04
- 神戸大学大学院 科学技術イノベーション研究科 特命准教授
- 2016/11
- 神戸大学大学院 科学技術イノベーション研究科 教授
- 2018/07
- 神戸大学 先端バイオ工学研究センター 教授
神戸大学大学院 科学技術イノベーション研究科 兼任 - 2018/11
- 神戸大学 先端バイオ工学研究センター 副センター長
及び 先端プラットフォーム技術開発部門・部門長
→2023年~(改組) 合成バイオ基盤部門長 - 2022/04
- 神戸大学 統合研究拠点 副拠点長
受賞等
- 2024 令和6年度学長表彰(財務貢献者)
- 2023 令和5年度学長表彰(財務貢献者)
- 2020 令和3年度学長表彰(財務貢献者)
- 2020 令和2年度学長表彰(財務貢献者)
- 2019 令和元年度学長表彰(財務貢献者)
- 2019 井植記念会 第43回井植文化賞(科学技術部門) 受賞
- 2018 第10回学長表彰(財務貢献者)受賞
- 2017 科学技術への顕著な貢献 2017(ナイスステップな研究者) に選定
- 2017 第9回学長表彰(財務貢献者) 受賞
- 2016 International Botanical Congress Excellent Scholar Award 受賞
- 2007 日本植物学会若手奨励賞 受賞
- 2005 日本植物形態学会奨励賞 受賞
発表論文
- Mitsunobu, H., Kita, Y., Nambu-Nishida, Y., Miyazaki, S., Nakajima, K., Taoka, K., Kondo, A., Nishida, K. (2025/4) Development of a highly efficient base editing system for Lactobacilli to improve probiotics and dissect essential functions Applied Microbiology and Biotechnology, 109(1), 96
- Li, A., Mitsunobu, H., Yoshioka, S., Suzuki, T., Kondo, A., Nishida, K. (2022/08) Cytosine base editing systems with minimized off-target effect and molecular size, Nature Communications, 13 4531
- Kashojiya, S., Lu, Y., Takayama, M., Komatsu, H., Minh, L., Nishida, K., Shirasawa, K., Miura, K., Nonaka, S., Masuda, J., Kondo, A., Ezura, H., Ariizumi, T. (2022/01) Modification of tomato breeding traits and plant hormone signaling by Target-AID, the genome-editing system inducing efficient nucleotide substitution, Horticulture Research, 9, uhab004
- Yuan, S., Kawasaki, S., Abdellatif, I.MY., Nishida, K., Kondo, A., Ariizumi, T., Ezura, H., Miura, K. (2021/04) Efficient base editing in tomato using a highly expressed transient system, Plant Cell Reports, 40(4): 667-676
- Nishida, K., Kondo, A. (2021/01) CRISPR-derived genome editing technologies for metabolic engineering, Metabolic Engineering, 63, 141-147
- Hanziker, J., Nishida, K., Kondo, A., Kishimoto, S., Ariizumi, T., Ezura, H. (2020/11) Multiple gene substitution by Target-AID base-editing technology in tomato, Scientific Reports, 10(1), 20471
- Shimatani, Z.*, Fujikura, U.*, Ishii, H., Matsui, Y., Suzuki, M., Ueke, Y., Taoka, K., Terada, R., Nishida, K., Kondo, A. (2018/10) Inheritance of co-edited genes by CRISPR-based targeted nucleotide substitutions in rice, Plant Physiology and Biochemistry, 131: 78-83
- Arazoe, T., Kondo, A., Nishida, K. (2018/09) Targeted nucleotide editing technologies for microbial metabolic engineering, Biotechnology Journal, 13(9), 1700596
- Shimatani, Z., Fujikura, U., Ishii, H., Terada, R., Nishida, K., Kondo, A. (2018/08) Herbicide tolerance-assisted multiplex targeted nucleotide substitution in rice, Data in Brief, 20: 1325-1331
- Nambu-Nishida, Y., Nishida, K., Hasunuma, T., Kondo, A. (2018/04) Genetic and physiological basis for antibody production by Kluyveromyces marxianus, AMB Express, 8: 56
- Banno, S., Nishida, K., Arazoe, T., Mitsunobu, H., Kondo, A. (2018/04) Deaminase-mediated multiplex genome editing in Escherichia coli, Nature Microbiology, 3, 423-429
- Yoshida, Y., Kuroiwa, H., Shimada, T., Yoshida, M., Ohnuma, M., Fujiwara, T., Imoto, Y., Yagisawa, F., Nishida, K., Hirooka, S., Misumi, O., Mogi, Y., Akakabe, Y., Matsushita, K., Kuroiwa, T. (2017/12) Glycosyltransferase MDR1 assembles a dividing ring for mitochondrial proliferation comprising polyglucan nanofilaments, Proceedings of the National Academy of Sciences of the United States of America, 114(50), 13284-13289
- Mitsunobu, H., Teramoto, J., Nishida, K., Kondo, A. (Review)(2017/10) Beyond native Cas9: manipulating genomic information and function, Trends in Biotechnology, 35(10), 983-996
- Nambu-Nishida, Y., Nishida, K., Hasunuma, T., Kondo, A. (2017/08) Development of a comprehensive set of tools for genome engineering in a cold- and thermo-tolerant Kluyveromyces marxianus yeast strain, Scientific Reports, 7(1): 8993
- Arazoe, T., Nishida, K., Kondo, A. (2017/06) Targeted nucleotide substitution in mammalian cell by Target-AID, Bio-protocol, 7: 11
- Shimatani, Z., Kashojiya, S., Takayama, M., Terada, R., Arazoe, T., Ishii, H., Teramura, H., Yamamoto, T., Komatsu, H., Miura, K., Ezura, H., Nishida, K., Ariizumi, T., Kondo, A. (2017/05) Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion, Nature Biotechnology, 35(5), 441-443
- Nishida, K., Arazoe, T., Yachie, N., Banno, S., Kakimoto, M., Tabata, M., Mochizuki, M., Miyabe, A., Araki, M., Hara, Y. K., Shimatani, Z., Kondo, A. (2016/09) Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems., Science,353, aaf8729
- Hara, K.Y., Aoki, N., Kobayashi, J., Kiriyama, K., Nishida K., Araki, M., Kondo, A. (2015/11) Improvement of oxidized glutathione fermentation by thiol redox metabolism engineering in Saccharomyces cerevisiae., Applied Microbiology and Biotechnology, 99(22), 9771-9778
- Ye, X., Morikawa, K., Ho, S.H., Nishida K., Araki, M., Hasunuma, T., Hara, K.Y., Kondo, A. (2015/04) Evaluation of genes involved in oxidative phosphorylation in yeast by developing a simple and rapid method to measure mitochondrial ATP synthetic activity, Microbial Cell Factories, 14: 56
- Yagisawa, F., Fujiwara, T., Ohnuma, M., Kuroiwa, H., Nishida, K., Imoto, Y., Yoshida, Y., Kuroiwa, T. (2013/08) Golgi inheritance in the primitive red alga, Cyanidioschyzon merolae, Protoplasma, 250(4), 943-948
- Imoto, Y., Kuroiwa, H., Yoshida, Y., Ohnuma, M., Fujiwara, T., Yoshida, M., Nishida, K., Yagisawa, F., Hirooka, S., Miyagishima, SY., Misumi, O., Kawano, S., Kuroiwa, T. (2013/06) Single-membrane-bounded peroxisome division revealed by isolation of dynamin-based machinery, Proceedings of the National Academy of Sciences of the United States of America, 110(23): 9583-8
- Yagisawa, F., Fujiwara, T., Kuroiwa, H., Nishida, K., Imoto, Y., Kuroiwa, T. (2012/10) Mitotic inheritance of endoplasmic reticulum in the primitive red alga Cyanidioschyzon merolae, Protoplasma, 249(4): 1129-35
- Nishida, K., Silver, PA. (2012/02) Induction of Biogenic Magnetization and Redox Control by a Component of the Target of Rapamycin Complex 1 Signaling Pathway, Plos Biology, 10(2): e1001269, Editors pick of the journal, highlighted in Nature Methods, and cited by several public news articles as "Magnetic yeast"
- Imoto, Y., Nishida, K., Yagisawa, F., Yoshida, Y., Ohnuma, M., Yoshida, M., Fujiwara, T., Kuroiwa, H., Kawano, S., Kuroiwa, T. (2011/12) Involvement of Elongation Factor-1α in Cytokinesis without Actomyosin Contractile Ring in the Primitive Red Alga Cyanidioschyzon merolae, Cytologia, 76(4): 431-437
- Fujiwara, T., Yagisawa, F., Ohnuma, M., Yoshida, Y., Yoshida, M., Nishida, K., Misumi, O., Kuroiwa, H., Kuroiwa, T. (2010/06) The Vacuole Binding to Mitochondria by VIG1 Contributes an Equal Inheritance of the Vacuoles in Cyanidioschyzon merolae, Cytologia, 75(2): 189-194
- Fujiwara, T., Kuroiwa, H., Yagisawa, F., Ohnuma, M., Yoshida, Y., Yoshida, M., Nishida, K., Misumi, O., Watanabe, S., Tanaka, K., Kuroiwa, T. (2010/03) The coiled-coil protein VIG1 is essential for tethering vacuoles to mitochondria during vacuole inheritance of Cyanidioschyzon merolae, Plant Cell, 22(3): 772-81
- Hirooka, S., Misumi, O., Yoshida, M., Mori, T., Nishida, K., Yagisawa, F., Yoshida, Y., Fujiwara, T., Kuroiwa, H., Kuroiwa, T. (2009/12) Expression of the Cyanidioschyzon merolae stromal ascorbate peroxidase in Arabidopsis thaliana enhances thermotolerance, Plant Cell Rep, 28(12): 1881-93
- Yagisawa, F., Nishida, K., Yoshida, M., Ohnuma, M., Shimada, T., Fujiwara, T., Yoshida, Y., Misumi, O., Kuroiwa, H., Kuroiwa, T. (2009/12) Identification of novel proteins in isolated polyphosphate vacuoles in the primitive red alga Cyanidioschyzon merolae, Plant Journal, 60(5): 882-93
- Fujiwara, T., Misumi, O., Tashiro, K., Yoshida, Y., Nishida, K., Yagisawa, F., Imamura, S., Yoshida, M., Mori, T., Tanaka, K., Kuroiwa, H., Kuroiwa, T. (2009/02) Periodic gene expression patterns during the highly synchronized cell nucleus and organelle division cycles in the unicellular red alga Cyanidioschyzon merolae, DNA Research, 16(1): 59-72
- Yoshida, Y., Nishida, K., Kuroiwa, T., Kawano, S. (2008/06) Novel Dynamics of FtsZ Ring Before Plastid Abscission, Cytologia, 73(1): 197-201
- Misumi, O., Yoshida, Y., Nishida, K., Fujiwara, T., Sakajiri, T., Hirooka, S., Nishimura, Y., Kuroiwa, T. (2008/01) Genome analysis and its significance in four unicellular algae, Cyanidioschyzon merolae, Ostreococcus tauri, Chlamydomonas reinhardtii, and Thalassiosira pseudonana, Journal Plant Research, 121(1): 3-17
- Yagisawa, F., Nishida, K., Kuroiwa, H., Nagata, T., Kuroiwa, T. (2007/09) Identification and mitotic partitioning strategies of vacuoles in the unicellular red alga Cyanidioschyzon merolae, Planta, 226(4): 1017-29
- Nozaki, H., Takano, H., Misumi, O., Terasawa, K., Matsuzaki, M., Maruyama, S., Nishida, K., Yagisawa, F., Yoshida, Y., Fujiwara, T., Takio, S., Tamura, K., Chung, SJ., Nakamura, S., Kuroiwa, H., Tanaka, K., Sato, N., Kuroiwa, T. (2007/07) A 100%-complete sequence reveals unusually simple genomic features in the hot-spring red alga Cyanidioschyzon merolae, BMC Biology, 5: 28
- Nishida, K., Yagisawa, F., Kuroiwa, H., Yoshida, Y., Kuroiwa, T. (2007/03) WD40 protein Mda1 is purified with Dnm1 and forms a dividing ring for mitochondria before Dnm1 in Cyanidioschyzon merolae, Proceedings of the National Academy of Sciences of the United States of America, 104(11): 4736-41
- Yoshida, Y., Kuroiwa, H., Misumi, O., Nishida, K., Yagisawa, F., Fujiwara, T., Nanamiya, H., Kawamura, F., Kuroiwa, T. (2006/09) Isolated chloroplast division machinery can actively constrict after stretching, Science, 313(5792): 1435-8
- Yagisawa, F., Nishida, K., Kuroiwa, H., Nagata, T., Kuroiwa, T. (2005/09) Identification of Lysosome-like Structures in a Unicellular Red Alga Cyanidioschyzon merolae, Cytologia, 70(1): 351-354
- Nishida, K., Yagisawa, F., Kuroiwa, H., Nagata, T., Kuroiwa, T. (2005/05) Cell Cycle-regulated, Microtubule-independent Organelle Division in Cyanidioschyzon merolae, Molecular Biology of the Cell, 16(5): 2493-502
- Misumi, O., Matsuzaki, M., Nozaki, H., Miyagishima, SY., Mori, T., Nishida, K., Yagisawa, F., Yoshida, Y., Kuroiwa, H., Kuroiwa, T. (2005/02) Cyanidioschyzon merolae genome. A tool for facilitating comparable studies on organelle biogenesis in photosynthetic eukaryotes, Plant Physiology, 137(2): 567-85
- Nishida, K., Misumi, O., Yagisawa, F., Kuroiwa, H., Nagata, T., Kuroiwa, T. (2004/07) Triple immunofluorescent labeling of FtsZ, dynamin, and EF-Tu reveals a loose association between the inner and outer membrane mitochondrial division machinery in the red alga Cyanidioschyzon merolae, Journal of Histochemistry & Cytochemistry, 52(7): 843-9
- Matsuzaki, M., Misumi, O., Shin-I, T., Maruyama, S., Takahara, M., Miyagishima, SY., Mori, T., Nishida, K., Yagisawa, F., Nishida, K., Yoshida, Y., Nishimura, Y., Nakao, S., Kobayashi, T., Momoyama, Y., Higashiyama, T., Minoda, A., Sano, M., Nomoto, H., Oishi, K., Hayashi, H., Ohta, F,, Nishizaka, S., Haga, S., Miura, S., Morishita, T., Kabeya, Y., Terasawa, K., Suzuki, Y., Ishii, Y., Asakawa, S., Takano, H., Ohta, N., Kuroiwa, H., Tanaka, K., Shimizu, N., Sugano, S., Sato, N., Nozaki, H., Ogasawara, N., Kohara, Y., Kuroiwa, T. (2004/04) Genome sequence of the ultrasmall unicellular red alga Cyanidioschyzon merolae 10D, Nature, 428(6983): 653-7
- Yagisawa, F., Nishida, K., Okano, Y., Minoda, A., Tanaka, K., Kuriowa, T. (2004/03) Isolation of Cycloheximide-resistant mutants of Cyanidioschyzon merolae, Cytologia, 69(1): 97-100
- Miyagishima, SY., Nozaki, H., Nishida, K., Nishida. K., Matsuzaki, M., Kuroiwa, T. (2004/03) Two types of FtsZ proteins in mitochondria and red-lineage chloroplasts: the duplication of FtsZ is implicated in endosymbiosis, Journal of Molecular Evolution, 58(3):291-303
- Miyagishima, SY., Nishida, K., Mori, T., Matsuzaki, M., Higashiyama, T., Kuroiwa, H., Kuroiwa, T. (2003/03) A plant-specific dynamin-related protein forms a ring at the chloroplast division site, Plant Cell, 15(3): 655-65
- Nishida, K., Takahara, M., Miyagishima, SY., Kuroiwa, H., Matsuzaki, M., Kuroiwa, T. (2003/02) Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga, Proceedings of the National Academy of Sciences of the United States of America, 100(4): 2146-51
総説・解説等
- 西田敬二, 第2章 高度なバイオものづくり用微生物を開発するための要素技術 -2. 微生物でのゲノム編集の有用性-, 微生物を活用した有用物質の製造技術, シーエムシー出版, 48-52 (2023/05)
- 西田敬二, 近藤昭彦, 最新のゲノム編集技術と用途展開, 第3編:微生物への応用と用途展開, 第9章 バクテリアでのゲノム編集の有用性, シーエムシー出版, 79-83 (2021/02)
- 大西美輪, 光延仁志, 西田敬二, 最新のゲノム編集技術と用途展開, 第2編:ゲノム編集ツールの開発動向, 第5章 DNA二重鎖切断を伴なわない塩基編集技術, シーエムシー出版, 43-50 (2021/02)
- 西田敬二,進展するゲノム編集, 現代化学, 1月号, No.562, <特集>生命をつくる:ゲノム編集の時代, 26-29 (2018/01)
- 西田 敬二, 島谷 善平, 近藤 昭彦, デアミナーゼを用いたゲノム編集, 植物の生長調節 (2017/06) 52(1), 15-18
- 西田敬二,第1章 3) 切断を伴わないゲノム編集ツール開発(デアミナーゼ他),『All About ゲノム編集』実験医学増刊号, 34(20), 羊土社,35-41 (2016/12)
- 近藤昭彦,西田敬二,荒添貴之,第3章 微生物でのゲノム編集の利用と拡大技術,ゲノム編集入門,裳華房,40-55 (2016/12)
- Kuroiwa T, Nishida K, Yoshida Y, Fujiwara T, Mori T, Kuroiwa H, Misumi O. Structure, function and evolution of the mitochondrial division apparatus. Biochimica et Biophysica Acta, 1763(5-6):510-21 (2006/05)
- Nishida K, Nagata T, Kuroiwa T. Cell cycle regulated organelles division in a primitive red alga. Plant Morphology, 17(1);51-55. (2005)
- Miyagishima SY, Nishida K, Kuroiwa T. An evolutionary puzzle: chloroplast and mitochondrial division rings. Trends in Plant Science, 8(9):432-8 (2003/09)