メンバー紹介

経歴

1993/03

東京大学　農学部　農芸化学科　卒業

1995/03

東京大学　大学院農学生命科学研究科　応用生命工学専攻　修士課程　修了

1997/04

日本学術振興会　特別研究員

1998/03

東京大学　大学院農学生命科学研究科　応用生命工学専攻　博士課程　修了

1999/04

理化学研究所　基礎科学特別研究員

2002/04

理化学研究所　協力研究員

2002/11

国立遺伝学研究所　助教

2006/04

大阪大学　微生物病研究所　助教

2009/04

スイス　ジュネーブ大学　博士研究員

2012/10

スイス　ジュネーブ大学　上級研究員

2019/05

群馬大学　研究員

2021/07

神戸大学　先端バイオ工学研究センター　特命准教授

発表論文

1. Hannich, JT., Umebayashi, K., Riezman, H. (2011) Distribution and functions of sterols and sphingolipids, Cold Spring Harbor Perspectives in Biology, 3(5), a004762
2. Umebayashi, K., Stenmark, H., Yoshimori, T. (2008) Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradation, Molecular Biology of the Cell, 19(8), 3454-3462
3. Kamimoto, T., Shoji, S., Hidvegi, T., Mizushima, N., Umebayashi, K., Perlmutter, DH., Yoshimori, T. (2006) Intracellular inclusions containing mutant alpha1-antitrypsin Z are propagated in the absence of autophagic activity, Journal of Biological Chemistry, 281(7), 4467-4476
4. Tsuda, K., Amano, A., Umebayashi, K., Inaba, H., Nakagawa, I., Nakanishi, Y., Yoshimori, T. (2005) Molecular dissection of internalization of Porphyromonas gingivalis by cells using fluorescent beads coated with bacterial membrane vesicle, Cell Structure and Function, 30(2), 81-91
5. Yamada, T., Carson, AR., Caniggia, I., Umebayashi, K., Yoshimori, T., Nakabayashi, K., Scherer, SW. (2005) Endothelial nitric oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast, Journal of Biological Chemistry, 280(18), 18283-18290
6. Nakatsukasa, K., Okada, S., Umebayashi, K., Fukuda, R., Nishikawa, S., Endo, T. (2004) Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast, Journal of Biological Chemistry, 279(48), 49762-49772
7. Umebayashi, K., Nakano, A. (2003) Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane, Journal of Cell Biology, 161(6), 1117-1131
8. Umebayashi, K.K, Fukuda, R., Hirata, A., Horiuchi, H., Nakano, A., Ohta, A., Takagi, M. (2001) Activation of the Ras-cAMP signal transduction pathway inhibits the proteasome-independent degradation of misfolded protein aggregates in the endoplasmic reticulum lumen. Journal of Biological Chemistry, 276 (44), 41444-41454 (2001)
9. Umebayashi, K., Hirata, A., Horiuchi, H., Ohta, A., Takagi, M. (1999) Unfolded protein response-induced BiP/Kar2p production protects cell growth against accumulation of misfolded protein aggregates in the yeast endoplasmic reticulum, European Journal of Cell Biology, 78(10), 726-738
10. Umebayashi, K., Hirata, A., Fukuda, R., Horiuchi, H., Ohta, A., Takagi, M. (1997) Accumulation of misfolded protein aggregates leads to the formation of Russell Body-like dilated endoplasmic reticulum in yeast, Yeast, 13(11), 1009-1020
11. Fukuda, R., Umebayashi, K., Horiuchi, H., Ohta, A., Takagi, M. (1996) Degradation of Rhizopus niveus aspartic proteinase-I with mutated prosequences occurs in the endoplasmic reticulum of Saccharomyces cerevisiae, Journal of Biological Chemistry, 271(24), 14252-14255