メンバー紹介

特命助教西村 勇哉 Yuya Nishimura

経歴

2008/03
神戸大学 工学部 応用化学科 卒業
2010/03
神戸大学大学院 工学研究科 応用化学専攻 博士前期課程 修了
2013/03
神戸大学大学院 工学研究科 応用化学専攻 博士後期課程 修了 博士(工学)
2013/04
神戸大学 自然科学系先端融合研究環 重点研究部 学術推進研究員
2015/07
神戸大学 自然科学系先端融合研究環 重点研究部 特命助教
2016/04
神戸大学大学院 科学技術イノベーション研究科 特命助教
2017/10
高機能遺伝子デザイン技術研究組合 研究員

受賞等

  • 2012/09 15th International Biotechnology Symposium and Exhibition) ポスター賞

発表論文

  1. Bin Mohamed Suffian, I. F., Mitla, GM., Paul, B., Bui, T., Nishimura, Y., Amir, R. B. M. J. P., Ogino, C., Kondo, A., Al-Jamal, K.T. (2017) Yield optimisation of hepatitis B virus core particles in E. coli expression system for drug delivery applications. Scientific Reports, 7: 43160
  2. Bin Mohamed Suffian, I. F., Wang, J. T-W., Hodgins, N. O., Klippstein, R., Garcia-Maya, M., Brown, P., Nishimura, Y., Heidari, H., Bals, S., Sosabowski, J., Ogino, C., Kondo, A., Al-Jamal, K. T. (2017) Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo., Biomaterials, 120, 126-138
  3. Nishimura, Y., Ezawa, R., Ishii, J., Ogino, C., Kondo, A. (2017) Affibody-displaying bio-nanocapsules effective in EGFR, typical biomarker, expressed in various cancer cells., Bioorganic & Medicinal Chemistry Letters, 27(2), 336-341
  4. Morita, K., Miyazaki, S., Numako, C., Ikeno, S., Sasaki, R., Nishimura, Y., Ogino, C., Kondo, A. (2016) Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel radiosensitizer., Free Radical Research, 50(12), 1319-1328
  5. Nakayama, M., Sasaki, R., Ogino, C., Tanaka, T., Morita, K., Umetsu, M., Ohara, S., Tan, Z., Nishimura, Y., Akasaka, H., Sato, K., Numako, C., Takami, S., Kondo, A. (2016) Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro and in vivo., Radiation Oncology,11(1):91
  6. Shen, L., Nishimura, Y., Matsuda, F., Ishii, J., Kondo, A. (2016) Overexpressing enzymes of the Ehrlich pathway and deleting genes of the competing pathway in Saccharomyces cerevisiae for increasing 2- phenylethanol production from glucose.,  Journal of Bioscience and Bioengineering, 122(1), 34-39
  7. Bin Mohamed Suffian, I. F., Nishimura, Y., Morita,K., Nakamura-Tsuruta, S., Al-Jamal, K. T., Ishii, J., Ogino, C., Kondo, A. (2015) Mutation of arginine residues to avoid non-specific cellular uptakes for hepatitis B virus core particles., Journal of Nanobiotechnology, 13(1): 15
  8. Nishimura, Y., Ishii, J., Ogino, C., Kondo, A. (Review) (2014) Genetic engineering of bio-nanoparticles for drug delivery: a review., Journal of Biomedical Nanotechnology, 10(9), 2063-2085
  9. Nishimura, Y., Takeda, K., Ezawa, R., Ishii, J., Ogino, C., Kondo, A. (2014) A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway., Journal of Nanobiotechnology, 21(1), 11
  10. Nishimura, Y., Mieda, H., Ishii, J., Ogino, C., Fujiwara, T., Kondo, A., (2013), Targeting cancer cell-specific RNA interference by siRNA delivery using a complex carrier of affibody-displaying bio-nanocapsules and liposomes. J Nanobiotechnology. 11(19).
  11. Nishimura, Y., Takeda, K., Ishii, J., Ogino, C., Kondo, A., (2013), An affinity chromatography method used to purify His-tag-displaying bio-nanocapsules. J Virol Methods. 189(2), 393-396.
  12. Nishimura, Y., Mimura, W., Bin Mohamed Suffian, I. F., Amino, T., Ishii, J., Ogino, C., Kondo, A., (2013), Granting specificity for breast cancer cells using a Hepatitis B core particle with a HER2-targeted affibody molecule. J Biochem. 153(3), 251-256.
  13. Nishimura, Y., Ishii, J., Okazaki, F., Ogino, C., Kondo, A., (2012),Complex carriers of affibody-displaying bio-nanocapsules and composition-varied liposomes for HER2-expressing breast cancer cell-specific protein delivery. J Drug Target. 20(10), 897-905.
  14. Nishimura, Y., Shishido, T., Ishii, J., Tanaka, T., Ogino, C., Kondo, A., (2012), Protein-encapsulated bio-nanocapsules production with ER membrane localization sequences. J Biotechnol. 157(1), 124-129.
  15. Shishido, T., Mieda, H., Hwang S.Y., Nishimura, Y., Tanaka, T., Ogino, C., Fukuda, H., Kondo, A., (2010), Affibody-displaying bionanocapsules for specific drug delivery to HER2-expressing cancer cells. Bioorg Med Chem Lett. 20, 5726-5731.

総説・解説等

  1. 西村勇哉,森田健太,鈴木貴弘,荻野千秋,近藤昭彦,無機とバイオの融合ナノ粒子によるがん治療戦略,粉砕,No.60, 13-19(2017)