メンバー紹介

特命准教授川口 秀夫 Hideo Kawaguchi

経歴

1997/03
東京薬科大学 薬学部衛生薬学科 卒業
1999/03
大阪大学 大学院薬学研究科環境生物薬学専攻 博士前期課程 修了
2002/03
大阪大学 大学院薬学研究科生命情報環境科学専攻 博士後期課程 修了 博士(薬学)
2002/04
地球環境産業技術研究機構 研究員
2007/04
東京大学 大学院工学系研究科 システム創成学専攻 特任助教
2012/10
神戸大学 大学院工学研究科 応用化学専攻 特命助教
2016/04
神戸大学 大学院科学技術イノベーション研究科 特命准教授
2017/06
高機能遺伝子デザイン技術研究組合 研究員
2017/12
神戸大学 大学院科学技術イノベーション研究科 特命准教授

発表論文

  1. Tominaga, D., Kawaguchi, H., Hori, Y., Hasunuma, T., Ogino, C., Aburatani, S. (2018) Mathematical model for small size time series data of bacterial secondary metabolic pathways, Bioinformatics and Biology Insights, 12: 1-7
  2. Kawaguchi, H., Yoshihara, K., Hara, K. Y., Hasunuma, T., Ogino, C., Kondo, A. (2018) Metabolome analysis-based design and engineering of a metabolic pathway in Corynebacterium glutamicum to match rates of simultaneous utilization of D-glucose and L-arabinose, Microbial Cell Factories, 17: 76
  3. Teramura, H., Sasaki, K., Oshima, T., Kawaguchi, H., Ogino, C., Sazuka, T., Kondo, A. (2018) Effective usage of sorghum bagasse: optimization of organosolv pretreatment using 25% 1-butanol and subsequent nanofiltration membrane separation, Bioresource Technology, 252, 157-164
  4. Kawaguchi, H., Ogino, C., Kondo, A. (2017) Microbial conversion of biomass into bio-based polymers, Bioresource Technology, 245(Part B), 1664-1673
  5. Kawaguchi, H., Katsuyama, Y., Danyao, D., P. Kahar, Nakamura-Tsuruta, S., Teramura, H., Wakai, K., Yoshihara K., Minami, H., Ogino, C., Ohnishi, Y., Kondo, A. (2017) Caffeic acid production by simultaneous saccharification and fermentation of kraft pulp using recombinant Escherichia coli, Appl Microbiol Biotechnoliol, 101(13), 5279–5290
  6. Sasaki, K., Tsuge, Y., Kawaguchi, H., Yasukawa, M., Sasaki, D., Sazuka, T., Kamio, E., Ogino, C., Matsuyama, H., Kondo, A. (2017) Sucrose purification and repeated ethanol production from sugars remaining in sweet sorghum juice subjected to a membrane separation process, Applied Microbiology and Biotechnology, 101(15): 6007-6014
  7. Teramura, H., Sasaki, K., Kawaguchi, H., Matsuda, F., Kikuchi, J., Shirai, T., Sazuka, T., Yamasaki, Y., Takumi, S., Ogino, C., Kondo, A. (2017) Differences in glucose yield of residues from among varieties of rice, wheat, and sorghum after dilute acid pretreatment. Bioscience Biotechnology and Biochemistry, 81(8), 1650-1656
  8. Goda, T., Teramura, H., Suehiro, M., Kanamaru, K., Kawaguchi, H., Ogino, C., Kondo, A., Yamasaki, M. (2016) Natural variation in the glucose content of dilute sulfuric acid–pretreated rice straw liquid hydrolysates: implications for bioethanol production., Bioscience, Biotechnology, and Biochemistry, 80(5), 863-869
  9. Tsuge, Y., Kudou, M., Kawaguchi, H., Ishii, J., Hasunuma, T., Kondo, A. (2016) FudC, a protein primary responsible for furfural detoxification in Corynebacterium glutamicum., Applied Microbiology and Biotechnology, 100(6), 2685-2692
  10. Nobuta, K., Teramura, H., Ito, H., Hongo, C., Kawaguchi, H, Ogino, C., Kondo, A., Nishino, T. (2016) Characterization of cellulose nanofiber sheets from different refining processes., Cellulose, 23(1), 403-414
  11. Kawaguchi, H., Hasunuma, T., Ogino, C., Kondo, A. (Review) (2016) Bioprocessing of bio-based chemicals produced from lignocellulosic feedstocks., Current Opinion in Biotechnology, 42: 30-39
  12. Teramura, H., Sasaki, K., Oshima, T., Matsuda, F., Okamoto, M., Shirai, T., Kawaguchi, H., Ogino, C., Hirano, K., Sazuka, T., Kitano, H., Kikuchi, J., Kondo, A. (2016) Organosolv pretreatment of sorghum bagasse using a low concentration of hydrophobic solvents such as 1-butanol or 1-pentanol., Biotechnology for Biofuels 9: 27
  13. Tsuge, Y., Kawaguchi, H., Sasaki, K., Kondo, A. (Review) (2016)  Engineering cell factories for producing building block chemicals for bio-polymer synthesis., Microbial Cell Factories, 15, 19
  14. Sasaki, K., Hara, K.Y., Kawaguchi, H., Sazuka, T., Ogino, C., Kondo, A. (2016) Nanofiltration concentration of extracellular glutathione produced by engineered Saccharomyces cerevisiae., Journal of Bioscience and Bioengineering, 121(1), 96-100
  15. Kawaguchi, H., Sasaki, K., Uematsu, K., Tsuge, Y., Teramura, H., Okai, N., Nakamura-Tsuruta, S., Katsuyama, Y., Sugai, Y., Ohnishi, Y., Hirano, K., Sazuka, T., Ogino, C., Kondo, A. (2015) 3-Amino-4-hydroxybenzoic acid production from sweet sorghum juice by recombinant Corynebacterium glutamicum., Bioresource Technology, 198: 410-417
  16. Sasaki, K., Okamoto, M., Shirai, T., Tsuge, Y., Teramura, H., Sasaki, D., Kawaguchi, H., Hasunuma, T., Ogino, C., Matsuda, F., Kikuchi, J., Kondo, A. (2015) Precipitate obtained following membrane separation of hydrothermally pretreated rice straw liquid revealed by 2D NMR to have high lignin content., Biotechnology for Biofuels, 8: 88
  17. Teramura, H., Sasaki, K., Oshima, T., Aikawa, S., Matsuda, F., Okamoto, M., Shirai, T., Kawaguchi, H., Ogino, C., Yamasaki, M., Kikuchi, J., Kondo, A. (2015) Changes in lignin and polysaccharide components in 13 cultivars of rice straw following dilute acid pretreatment as studied by solution-state 2D 1 H-13 C NMR, PLOS ONE, 10(6), e0128417
  18. Sasaki, K., Tsuge, Y., Sasaki, D., Kawaguchi, H., Sazuka, T., Ogino, C., Kondo, A. (2015) Repeated ethanol production from sweet sorghum juice concentrated by membrane separation, Bioresource Technology , 186: 351-355
  19. Kawaguchi, H., Teramura, H., Uematsu, K., Hara, K.Y., Hasunuma, T., Hirano, K., Sazuka, T., Kitano, H., Tsuge, Y., Kahar, P., Niimi-Nakamura, S., Oinuma, K., Takaya, N., Kasuga, S., Ogino, C., Kondo, A. (2015) Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse., Bioresource Technology, 182:169-178
  20. Sasaki, K., Tsuge, Y., Sasaki, D., Teramura, H., Wakai, S., Kawaguchi, H., Suzuka, T., Ogino, C., Kondo, A. (2014) Increased ethanol production from sweet sorghum juice concentrated by a membrane separation process., Bioresource Technology, 169: 821-825
  21. Kawaguchi, H., Uematsu, K., Ogino, C., Teramura, H., Niimi-Nakamura, S., Tsuge, Y., Hasunuma, T., Oinuma, K., Takaya, N., Kondo, A. (2014) Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production., Biochemical Engineering Journal, 88: 188-194
  22. Tsuge, Y., Kawaguchi, H., Sasaki, K., Tanaka, T., Kondo, A. (2014) Two-step production of D-lactate from mixed sugars by growing and resting cells of metabolically engineered Lactobacillus plantarum., Applied Microbiology and Biotechnology, 98(11): 4911-4918
  23. Fu Q., Kobayashi H., Kawaguchi, H., Wakayama T., Maeda H., Sato K. (2013) A thermophilic Gram-negative nitrate-reducing bacterium, Calditerrivibrio nitroreducens, exhibiting electricity generation capability. Environ Sci Technol. 47(21):12583−12590.
  24. Hara, M., Onaka, Y., Kobayashi, H., Fu, Q., Kawaguchi, H., Vilcaez, J., Sato, K. (2013) Mechanism of electromethanogenic reduction of CO2 by a thermophilic methanogen. Energy Proced. 37:7021-7028.
  25. Kuramochi, Y., Fu, Q., Kobayashi, H., Ikarashi, M., Wakayama, T., Kawaguchi, H., Vilcaez, J., Maeda, H., and Sato, K. (2013) Electromethanogenic CO2 conversion by subsurface-reservoir microorganisms. Energy Proced. 37:7014-7020.
  26. Fu, Q., Kobayashi, H., Kawaguchi, H., Vilcaez, J., and Sato, K. (2013) Identification of new microbial mediators for electromethanogenic reduction of geologically-stored carbon dioxide. Energy Proced. 37:7006-7013.
  27. Kobayashi, H., N. Saito, Fu, Q., Kawaguchi, H., Vilcaez, J., Wakayama, T., Maeda, H., and Sato, K. (2013) Bio-electrochemical property and phylogenetic diversity of microbial communities associated with bioelectrodes of an electromethanogenic reactor. J Biosci Bioeng. 16(1):114-117
  28. Sato, K., Kawaguchi, H., and Kobayashi, H. (2013) Bio-electrochemical conversion of carbon dioxide to methane in geological storage reservoirs. Energy Convers Manage. 66: 343-350
  29. Fu, Q., Kobayashi, H., Kawaguchi, H., Vilcaez, J., Wakayama, T., Maeda H. and Sato, K. (2013) Electrochemical and phylogenetic analyses of current-generating microorganisms in a thermophilic microbial fuel cell. J Biosci Bioeng, 115(3):268-271
  30. Kawaguchi, H., Li, Z., Masuda, Y., Sato, K., and Nakagawa, H. (2012) Dissolved organic compounds in reused process water for steam-assisted gravity drainage oil sands extraction. Water Res. 46:5566-5574.
  31. Kawaguchi, H., Kobayashi, H., and Sato, K. (2012) Metabolic engineering of hydrophilic Rhodococcus opacus for biodesulfurization in oil-water biphasic reaction mixtures. J Biosci Bioeng. 113:360-366.
  32. Kobayashi, H., Endo, K., Sakata, S., Mayumi, D., Kawaguchi, H., Ikarashi, M., Miyagawa, Y., Maeda, H., and Sato, K. (2012) Phylogenetic diversity of microbial communities associated with the crude-oil, large-insoluble-particle and formation-water components of the reservoir fluid from a non-flooded high-temperature petroleum reservoir. J Biosci Bioeng. 113:204-210.
  33. Kobayashi, H., Kawaguchi, H., Endo, K., Mayumi, D., Sakata, S., Ikarashi, M., Miyagawa, Y., Maeda, H., and Sato, K. (2012) Analysis of methane production by microorganisms indigenous to a depleted oil reservoir for application in microbial enhanced oil recovery. J Biosci Bioeng. 113:84-87.
  34. Kawaguchi, H., Sakuma, T., Nakata, Y., Kobayashi, H., Endo, K., and Sato, K. (2010) Methane production by Methanothermobacter thermautotrophicus to recover energy from carbon dioxide sequestered in geological reservoirs. J Biosci Bioeng. 110: 106-108.
  35. Sasaki, M., Jojima, T., Kawaguchi, H., Inui, M., and Yukawa, H. (2009) Engineering of pentose transport in Corynebacterium glutamicum to improve simultaneous utilization of mixed sugars. Appl Microbiol Biotechnol. 85:105-115.
  36. Kawaguchi, H., M. Sasaki, A. A. Vertès, Inui, M., and Yukawa, H. (2009) Identification and functional analysis of the gene cluster for L-arabinose utilization in Corynebacterium glutamicum. Appl Environ Microbiol. 75:3419–3429.
  37. Kawaguchi, H., M. Sasaki, A. A. Vertès, M. Inui, M., and Yukawa, H. (2008) Engineering of an L-arabinose metabolic pathway in Corynebacterium glutamicum. Appl Microbiol Biotechnol. 77:1053-1062.
  38. Sakai, S., Y. Tsuchida, S. Okino, O. Ichihashi, H. Kawaguchi, T. Watanabe, Inui, M., and Yukawa, H. (2007) Effect of lignocellulose-derived inhibitors on growth and ethanol production by growth-arrested Corynebacterium glutamicum R. Appl Environ Microbiol. 73:2349-2353.
  39. Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., and Yukawa, H. (2007) Efficient induction of formate hydrogen lyase of aerobically grown Escherichia coli in a three-step biohydrogen production process. Appl Microbiol Biotechnol. 74:754-760.
  40. Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., and Yukawa, H. (2006) Enhanced hydrogen production from glucose using ldh- and frd-inactivated Escherichia coli strains. Appl Microbiol Biotechnol. 73:67-72.
  41. Kawaguchi, H., Vertès, A. A., Okino, S., Inui, M., and Yukawa, H. (2006) Engineering of a xylose metabolic pathway in Corynebacterium glutamicum. Appl Environ Microbiol. 72:3418-3428.
  42. Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., and Yukawa, H. (2005) Enhanced hydrogen production from formic acid by formate hydrogen lyase-overexpressing Escherichia coli strains. Appl Environ Microbiol. 71:6762-6768.
  43. Inui, M., Kawaguchi, H., Murakami, S., Vertès, A. A., and Yukawa, H. (2004) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J Mol Microbiol Biotechnol. 8:243-254.
  44. Inui, M., Murakami, S., Okino, S., Kawaguchi, H., Vertès, A. A., and Yukawa, H. (2004) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions. J Mol Microbiol Biotechnol. 7:182-196.
  45. Kawaguchi, H., Nagase, H., Kimata, S., Doi, M., Hirata, K., and Miyamoto, K. (2002) Effect of algal extract on H2 production by a photosynthetic bacterium Rhodobium marinum A-501: Analysis of stimulating effect by a kinetic model. J Biosci Bioeng. 94:62-69.
  46. Kawaguchi, H., Hashimoto, K., Hirata, K., and Miyamoto, K. (2001) H2 production from algal biomass by a mixed culture of Rhodobium marinum A-501 and Lactobacillus amylovorus. J Biosci Bioeng. 91:277-282
  47. Ike, A., Murakawa, T., Kawaguchi, H., Hirata, K., and Miyamoto, K. (1999) Photoproduction of hydrogen from raw starch using a halophilic bacterial community. J Biosci Bioeng. 88:72-77.

総説・解説等

  1. 川口秀夫, 近藤昭彦, リグノセルロース系バイオマスからのバイオモノマー発酵生産, ケミカルエンジニヤリング,Vol.62, No.3, 13-20 (2017)
  2. 荻野千秋, 川口 秀夫, 近藤昭彦, スーパーバイオマス, 第6章, バイオリファイナリー, 慶応義塾大学出版会, 87-104 (2016)
  3. 荻野千秋,中村聡子,岡井直子,若井暁,川口 秀夫,近藤昭彦,バイオマスからの微生物によるバイオモノマー生産,ケミカルエンジニヤリング,Vol.59, No.7, 22-31
  4. 寺村浩,延田紘治,川口 秀夫,荻野千秋,西野孝,近藤昭彦,植物の機能解明と新たな機能材料創出の可能性,バイオインダストリー,Vol.31, No.4, 62-68(2014)
  5. 川口 秀夫(2007)地下微生物圏へのアプローチ:石油と微生物の関わり、生物工学会誌 85(12):550.
  6. 川口 秀夫、湯川 英明(2006)バイオ法水素生産の新展開Ceramics Japan, 41:312.
  7. Kawaguchi, H. and H. Yukawa (2006) H2 production from formic acid using an innovative bioprocess, The Journal of Fuel Cell Technology, 5(4):83-85.
  8. 川口 秀夫、湯川 英明(2006)バイオ水素研究の展開、電気評論, 91 (10):62-63.
  9. 川口 秀夫、湯川 英明(2005)Ⅱ.生物工学技術の実際 「バイオマス資源からのエタノール生産」、監修:社会法人 日本生物工学会 塩谷 捨明(編集)、『生物工学ハンドブック』㈱コロナ社、東京、pp.220-225.
  10. 川口 秀夫、湯川 英明(2005)第1章 エコエタノール 「6. RITEバイオプロセスによるエタノール製造」、監修:植田充美、近藤昭彦『エコバイオエネルギーの最前線:ゼロエミッション型社会を目指して』 ㈱シーエムシー出版、東京、pp.60-67.
  11. 川口 秀夫、湯川 英明(2004)「バイオ水素法の新展開」、監修:湯川英明『CO2固定化・削減・有効利用の最新技術:地球温暖化対策関連技術』 ㈱シーエムシー出版、東京、pp.220-225.
  12. Ike, A., H. Kawaguchi, K. Hirata, and K. Miyamoto. (2001) Hydrogen photoproduction from starch in algal biomass. in Miyake, J. (ed.), Biohydrogen II, Pergamon Press, Amsterdam, pp. 53-61.