メンバー紹介

TOP メンバー（先端バイオ） 川口　秀夫

特命准教授川口　秀夫 Hideo Kawaguchi

経歴

1997/03
東京薬科大学　薬学部衛生薬学科　卒業
1999/03
大阪大学　大学院薬学研究科環境生物薬学専攻 博士前期課程　修了
2002/03
大阪大学　大学院薬学研究科生命情報環境科学専攻 博士後期課程　修了 博士（薬学）
2002/04
地球環境産業技術研究機構　研究員
2007/04
東京大学　大学院工学系研究科　システム創成学専攻　特任助教
2012/10
神戸大学　大学院工学研究科　応用化学専攻　特命助教
2016/04
神戸大学　大学院科学技術イノベーション研究科　特命准教授
2017/06
高機能遺伝子デザイン技術研究組合　研究員
2017/12
神戸大学　大学院科学技術イノベーション研究科　特命准教授
2018/07
神戸大学　先端バイオ工学研究センター　特命准教授

受賞等

  • 2022/10　令和４年度学長表彰（財務貢献者）
  • 2021/10　令和３年度学長表彰（財務貢献者）
  • 2020/10　令和２年度学長表彰（財務貢献者）
  • 2019/10　令和元年度学長表彰（財務貢献者）
  • 2013/08　Ghent Biobased Economy Belgium, 英国王立化学協会出版（RSC Publishing）最優秀ポスター賞
    　　　　　Green Chemistry Poster Prize, Ghent Biobased Economy Belgium

発表論文

  1. Niimi-Nakamura, S., Kawaguchi, H., Uematsu, K., Teramura, H., Tsuruta, S., Kashiwagi, N., Sugai, Y., Katsuyama, Y., Ohnishi, Y., Ogino, C., Kondo, A. (2022/07) 3-Amino-4-hydroxybenzoic acid production from glucose and/or xylose via recombinant Streptomyces lividans, The Journal of General and Applied Microbiology, 68(2), 109-116
  2. Kawaguchi, H., Takada, K., Elkasaby, T., Pangestu, R., Toyoshima, M., Kahar, P., Ogino, C., Kaneko, T., Kondo, A. (2022/01) Recent advances in lignocellulosic biomass white biotechnology for bioplastics, Bioresource Technology, 344(B): 126165
  3. Kawaguchi, H., Hasunuma, T., Ohnishi, Y., Sazuka, T., Kondo, A., Ogino, C. (2021/12) Enhanced production of γ-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation, Microbial Cell Factories, 20: 228
  4. Sakuragawa, T., Wakai, S., Zhang, S., Kawaguchi, H., Ogino, C., Kondo, A. (2021/08) Accelerated glucose metabolism in hyphae-dispersed Aspergillus oryzae is suitable for biological production, Journal of Bioscience and Bioengineering, 132(2), 140-147
  5. Wolf, S, Becker, J., Tsuge, Y., Kawaguchi, H., Kondo, A., Marienhagen, J., Bott, M., Wendisch, V.F., Wittmann, C. (Review) (2021/06) Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being, Essays in Biochemistry, 65(2): 197–212
  6. Kaffashsaie, E., Yousefi, H., Nishino, T., Matsumoto, T., Mashkour, M., Madhoushi, M., Kawaguchi, H. (2021/06) Direct conversion of raw wood to TEMPO-oxidized cellulose nanofibers, Carbohydrate polymers, 262(15): 117938
  7. Hashimoto, S., Wake, T., Nakamura, H., Minamiyama, M., Araki-Nakamura, S., Ohmae-Shinohara, K., Koketsu, E., Okamura, S., Miura, K., Kawaguchi, H., Kasuga, S., Sazuka, T. (2021/02) The dominance model for heterosis explains culm length genetics in a hybrid sorghum variety, Scietific Reports, 11(1): 4532
  8. Nag, A., Ali, MA., Kawaguchi, H., Saito, S., Kawasaki, Y., Miyazaki, S., Kawamoto, H., Nugroho Adi, DT., Yoshihara, K., Masuo, S., Katsuyama, Y., Kondo, A., Ogino, C., Takaya, N., Kaneko, T.*, Ohnishi, Y. (2021/01) Ultrahigh thermoresistant lightweight bioplastics developed from fermentation products of cellulosic feedstock, Advanced Sustainable Systems, 5(1), 2000193
  9. Kawaguchi, H., Sazuka, T., Kondo, A. (2020/08) Complete and draft genome sequences of amino acid-producing Corynebacterium glutamicum strains ATCC 21799 and ATCC 31831 and their genomic islands, Microbiology Resource Announcements, 9(32), e00430-20
  10. Kobayashi, S., Kawaguchi, H., Shirai, T., Ninomiya, K., Takahashi, K., Kondo, A., Tsuge, Y. (2020/03) Automatic redirection of carbon flux between glycolysis and pentose phosphate pathway using an oxygen-responsive metabolic switch in Corynebacterium glutamicum, ACS Synthetic Biology, 9, 814-826
  11. Kawaguchi, H., Miyagawa, H., Nakamura-Tsuruta, S., Takaya, N., Ogino, C., Kondo, A. (2019/06) Enhanced phenyllactic acid production in Escherichia coli via oxygen limitation and shikimate pathway gene expression. Biotechnology Journal, 14(6): 1800478
  12. Wijaya, H., Sasaki, K., Kahar, P., Yopi, Kawaguchi, H., Sazuka, T., Ogino, C., Prasetya, B., Kondo, A. (2018/10) Repeated ethanol fermentation from membrane-concentrated sweet sorghum juice using the flocculating yeast Saccharomyces cerevisiae F118 strain, Bioresource Technology, 265, 542-547
  13. Tsuge, Y., Kawaguchi, H., Yamamoto, S., Nishigami, Y., Sota, M., Ogino, C., Kondo, A. (2018/07) Metabolic engineering of Corynebacterium glutamicum for production of sunscreen shinorine, Bioscience, Biotechnology, and Biochemistry, 82(7): 1252-1259 (7月号表紙採用)
  14. Tominaga, D., Kawaguchi, H., Hori, Y., Hasunuma, T., Ogino, C., Aburatani, S. (2018/05) Mathematical model for small size time series data of bacterial secondary metabolic pathways, Bioinformatics and Biology Insights, 12: 1-7
  15. Kawaguchi, H., Yoshihara, K., Hara, K.Y., Hasunuma, T., Ogino, C., Kondo, A. (2018/05) Metabolome analysis-based design and engineering of a metabolic pathway in Corynebacterium glutamicum to match rates of simultaneous utilization of D-glucose and L-arabinose, Microbial Cell Factories, 17: 76
  16. Teramura, H., Sasaki, K., Oshima, T., Kawaguchi, H., Ogino, C., Sazuka, T., Kondo, A. (2018/03) Effective usage of sorghum bagasse: optimization of organosolv pretreatment using 25% 1-butanol and subsequent nanofiltration membrane separation, Bioresource Technology, 252, 157-164
  17. Kawaguchi, H., Ogino, C., Kondo, A. (2017/12) Microbial conversion of biomass into bio-based polymers, Bioresource Technology, 245(Part B), 1664-1673
  18. Sasaki, K., Tsuge, Y., Kawaguchi, H., Yasukawa, M., Sasaki, D., Sazuka, T., Kamio, E., Ogino, C., Matsuyama, H., Kondo, A. (2017/08) Sucrose purification and repeated ethanol production from sugars remaining in sweet sorghum juice subjected to a membrane separation process, Applied Microbiology and Biotechnology, 101(15): 6007-6014
  19. Teramura, H., Sasaki, K., Kawaguchi, H., Matsuda, F., Kikuchi, J., Shirai, T., Sazuka, T., Yamasaki, Y., Takumi, S., Ogino, C., Kondo, A. (2017/08) Differences in glucose yield of residues from among varieties of rice, wheat, and sorghum after dilute acid pretreatment, Bioscience Biotechnology and Biochemistry, 81(8), 1650-1656
  20. Kawaguchi, H., Katsuyama, Y., Danyao, D., P. Kahar, Nakamura-Tsuruta, S., Teramura, H., Wakai, K., Yoshihara K., Minami, H., Ogino, C., Ohnishi, Y., Kondo, A. (2017/07) Caffeic acid production by simultaneous saccharification and fermentation of kraft pulp using recombinant Escherichia coli, Appl Microbiol Biotechnoliol, 101(13), 5279–5290
  21. Kawaguchi, H., Hasunuma, T., Ogino, C., Kondo, A. (Review) (2016/12) Bioprocessing of bio-based chemicals produced from lignocellulosic feedstocks, Current Opinion in Biotechnology, 42: 30-39
  22. Teramura, H., Sasaki, K., Oshima, T., Matsuda, F., Okamoto, M., Shirai, T., Kawaguchi, H., Ogino, C., Hirano, K., Sazuka, T., Kitano, H., Kikuchi, J., Kondo, A. (2016/12) Organosolv pretreatment of sorghum bagasse using a low concentration of hydrophobic solvents such as 1-butanol or 1-pentanol, Biotechnology for Biofuels, 9: 27
  23. Goda, T., Teramura, H., Suehiro, M., Kanamaru, K., Kawaguchi, H., Ogino, C., Kondo, A., Yamasaki, M. (2016/05) Natural variation in the glucose content of dilute sulfuric acid–pretreated rice straw liquid hydrolysates: implications for bioethanol production, Bioscience, Biotechnology, and Biochemistry, 80(5), 863-869
  24. Tsuge, Y., Kudou, M., Kawaguchi, H., Ishii, J., Hasunuma, T., Kondo, A. (2016/03) FudC, a protein primarily responsible for furfural detoxification in Corynebacterium glutamicum, Applied Microbiology and Biotechnology, 100(6), 2685-2692
  25. Nobuta, K., Teramura, H., Ito, H., Hongo, C., Kawaguchi, H., Ogino, C., Kondo, A., Nishino, T. (2016/02) Characterization of cellulose nanofiber sheets from different refining processes, Cellulose, 23(1), 403-414
  26. Tsuge, Y., Kawaguchi, H., Sasaki, K., Kondo, A. (Review) (2016/01) Engineering cell factories for producing building block chemicals for bio-polymer synthesis, Microbial Cell Factories, 15, 19
  27. Sasaki, K., Hara, K.Y., Kawaguchi, H., Sazuka, T., Ogino, C., Kondo, A. (2016/01) Nanofiltration concentration of extracellular glutathione produced by engineered Saccharomyces cerevisiae, Journal of Bioscience and Bioengineering, 121(1), 96-100
  28. Kawaguchi, H., Sasaki, K., Uematsu, K., Tsuge, Y., Teramura, H., Okai, N., Nakamura-Tsuruta, S., Katsuyama, Y., Sugai, Y., Ohnishi, Y., Hirano, K., Sazuka, T., Ogino, C., Kondo, A. (2015/12) 3-Amino-4-hydroxybenzoic acid production from sweet sorghum juice by recombinant Corynebacterium glutamicum, Bioresource Technology, 198: 410-417
  29. Sasaki, K., Okamoto, M., Shirai, T., Tsuge, Y., Teramura, H., Sasaki, D., Kawaguchi, H., Hasunuma, T., Ogino, C., Matsuda, F., Kikuchi, J., Kondo, A. (2015/06) Precipitate obtained following membrane separation of hydrothermally pretreated rice straw liquid revealed by 2D NMR to have high lignin content, Biotechnology for Biofuels, 8: 88
  30. Teramura, H., Sasaki, K., Oshima, T., Aikawa, S., Matsuda, F., Okamoto, M., Shirai, T., Kawaguchi, H., Ogino, C., Yamasaki, M., Kikuchi, J., Kondo, A. (2015/06) Changes in lignin and polysaccharide components in 13 cultivars of rice straw following dilute acid pretreatment as studied by solution-state 2D 1 H-13 C NMR, PLOS ONE, 10(6), e0128417
  31. Sasaki, K., Tsuge, Y., Sasaki, D., Kawaguchi, H., Sazuka, T., Ogino, C., Kondo, A. (2015/06) Repeated ethanol production from sweet sorghum juice concentrated by membrane separation, Bioresource Technology, 186: 351-355
  32. Kawaguchi, H., Teramura, H., Uematsu, K., Hara, K.Y., Hasunuma, T., Hirano, K., Sazuka, T., Kitano, H., Tsuge, Y., Kahar, P., Niimi-Nakamura, S., Oinuma, K., Takaya, N., Kasuga, S., Ogino, C., Kondo, A. (2015/04) Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse, Bioresource Technology, 182: 169-178
  33. Sasaki, K., Tsuge, Y., Sasaki, D., Teramura, H., Wakai, S., Kawaguchi, H., Suzuka, T., Ogino, C., Kondo, A. (2014/10) Increased ethanol production from sweet sorghum juice concentrated by a membrane separation process, Bioresource Technology, 169: 821-825
  34. Kawaguchi, H., Uematsu, K., Ogino, C., Teramura, H., Niimi-Nakamura, S., Tsuge, Y., Hasunuma, T., Oinuma, K., Takaya, N., Kondo, A. (2014/07) Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production, Biochemical Engineering Journal, 88: 188-194
  35. Tsuge, Y., Kawaguchi, H., Sasaki, K., Tanaka, T., Kondo, A. (2014/06) Two-step production of D-lactate from mixed sugars by growing and resting cells of metabolically engineered Lactobacillus plantarum, Applied Microbiology and Biotechnology, 98(11): 4911-4918
  36. Hara, M., Onaka, Y., Kobayashi, H., Fu, Q., Kawaguchi, H., Vilcaez, J., Sato, K. (2013/12) Mechanism of electromethanogenic reduction of CO2 by a thermophilic methanogen, Energy Proced., 37: 7021-7028
  37. Kuramochi, Y., Fu, Q., Kobayashi, H., Ikarashi, M., Wakayama, T., Kawaguchi, H., Vilcaez, J., Maeda, H., Sato, K. (2013/12) Electromethanogenic CO2 conversion by subsurface-reservoir microorganisms, Energy Proced, 37: 7014-7020
  38. Fu, Q., Kobayashi, H., Kawaguchi, H., Vilcaez, J., Sato, K. (2013/12) Identification of new microbial mediators for electromethanogenic reduction of geologically-stored carbon dioxide, Energy Proced, 37: 7006-7013
  39. Fu, Q., Kobayashi, H., Kawaguchi, H., Wakayama, T., Maeda, H., Sato, K. (2013/11) A thermophilic Gram-negative nitrate-reducing bacterium, Calditerrivibrio nitroreducens, exhibiting electricity generation capability, Environ Sci Technol., 47(21): 12583−12590
  40. Fu, Q., Kobayashi, H., Kawaguchi, H., Vilcaez, J., Wakayama, T., Maeda H., Sato, K. (2013/03) Electrochemical and phylogenetic analyses of current-generating microorganisms in a thermophilic microbial fuel cell, J Biosci Bioeng., 115(3): 268-271
  41. Sato, K., Kawaguchi, H., Kobayashi, H. (2013/02) Bio-electrochemical conversion of carbon dioxide to methane in geological storage reservoirs, Energy Convers Manage, 66: 343-350
  42. Kobayashi, H., Saito, N., Fu, Q., Kawaguchi, H., Vilcaez, J., Wakayama, T., Maeda, H., Sato, K. (2013/01) Bio-electrochemical property and phylogenetic diversity of microbial communities associated with bioelectrodes of an electromethanogenic reactor, J Biosci Bioeng., 16(1): 114-117
  43. Kawaguchi, H., Li, Z., Masuda, Y., Sato, K., Nakagawa, H. (2012/11) Dissolved organic compounds in reused process water for steam-assisted gravity drainage oil sands extraction, Water Res., 46: 5566-5574
  44. Kawaguchi, H., Kobayashi, H., Sato, K. (2012/03) Metabolic engineering of hydrophilic Rhodococcus opacus for biodesulfurization in oil-water biphasic reaction mixtures, J Biosci Bioeng., 113: 360-366
  45. Kobayashi, H., Endo, K., Sakata, S., Mayumi, D., Kawaguchi, H., Ikarashi, M., Miyagawa, Y., Maeda, H., Sato, K. (2012/02) Phylogenetic diversity of microbial communities associated with the crude-oil, large-insoluble-particle and formation-water components of the reservoir fluid from a non-flooded high-temperature petroleum reservoir J Biosci Bioeng., 113: 204-210
  46. Kobayashi, H., Kawaguchi, H., Endo, K., Mayumi, D., Sakata, S., Ikarashi, M., Miyagawa, Y., Maeda, H., Sato, K. (2012/01) Analysis of methane production by microorganisms indigenous to a depleted oil reservoir for application in microbial enhanced oil recovery, J Biosci Bioeng., 113: 84-87
  47. Kawaguchi, H., Sakuma, T., Nakata, Y., Kobayashi, H., Endo, K., and Sato, K. (2010/07) Methane production by Methanothermobacter thermautotrophicus to recover energy from carbon dioxide sequestered in geological reservoirs, J Biosci Bioeng., 110: 106-108
  48. Sasaki, M., Jojima, T., Kawaguchi, H., Inui, M., Yukawa, H. (2009/11) Engineering of pentose transport in Corynebacterium glutamicum to improve simultaneous utilization of mixed sugars, Appl Microbiol Biotechnol., 85: 105-115
  49. Kawaguchi, H., Sasaki, M., Vertès, A.A., Inui, M., Yukawa, H. (2009/06) Identification and functional analysis of the gene cluster for L-arabinose utilization in Corynebacterium glutamicum, Appl Environ Microbiol., 75: 3419–3429
  50. Kawaguchi, H., Sasaki, M., Vertès, A.A., Inui, M., Yukawa, H. (2008/01) Engineering of an L-arabinose metabolic pathway in Corynebacterium glutamicum, Appl Microbiol Biotechnol., 77: 1053-1062
  51. Sakai, S., Tsuchida, Y., Okino, S., Ichihashi, O., Kawaguchi, H,, Watanabe, T., Inui, M., Yukawa, H. (2007/04) Effect of lignocellulose-derived inhibitors on growth and ethanol production by growth-arrested Corynebacterium glutamicum R, Appl Environ Microbiol., 73: 2349-2353
  52. Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., Yukawa, H. (2007/03) Efficient induction of formate hydrogen lyase of aerobically grown Escherichia coli in a three-step biohydrogen production process, Appl Microbiol Biotechnol., 74: 754-760
  53. Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., Yukawa, H. (2006/11) Enhanced hydrogen production from glucose using ldh- and frd-inactivated Escherichia coli strains, Appl Microbiol Biotechnol., 73: 67-72
  54. Kawaguchi, H., Vertès, A.A., Okino, S., Inui, M., Yukawa, H. (2006/05) Engineering of a xylose metabolic pathway in Corynebacterium glutamicum, Appl Environ Microbiol., 72: 3418-3428
  55. Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., Yukawa, H. (2005/11) Enhanced hydrogen production from formic acid by formate hydrogen lyase-overexpressing Escherichia coli strains, Appl Environ Microbiol., 71: 6762-6768
  56. Inui, M., Kawaguchi, H., Murakami, S., Vertès, A.A., Yukawa, H. (2004) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions, J Mol Microbiol Biotechnol., 8: 243-254
  57. Inui, M., Murakami, S., Okino, S., Kawaguchi, H., Vertès, A.A., Yukawa, H. (2004/09) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions, J Mol Microbiol Biotechnol., 7: 182-196
  58. Kawaguchi, H., Nagase, H., Kimata, S., Doi, M., Hirata, K., Miyamoto, K. (2002/07) Effect of algal extract on H2 production by a photosynthetic bacterium Rhodobium marinum A-501: Analysis of stimulating effect by a kinetic model, J Biosci Bioeng., 94: 62-69
  59. Kawaguchi, H., Hashimoto, K., Hirata, K., Miyamoto, K. (2001) H2 production from algal biomass by a mixed culture of Rhodobium marinum A-501 and Lactobacillus amylovorus, J Biosci Bioeng., 91: 277-282
  60. Ike, A., Murakawa, T., Kawaguchi, H., Hirata, K., Miyamoto, K. (1999) Photoproduction of hydrogen from raw starch using a halophilic bacterial community, J Biosci Bioeng., 88: 72-77

総説・解説等

  1. 川口秀夫, 近藤昭彦, リグノセルロース系バイオマスからのバイオモノマー発酵生産, ケミカルエンジニヤリング, Vol.62, No.3, 13-20 (2017/03)
  2. 荻野千秋, 川口秀夫, 近藤昭彦, スーパーバイオマス, 第６章, バイオリファイナリー, 慶応義塾大学出版会, 87-104 (2016/02)
  3. 荻野千秋, 中村聡子, 岡井直子, 若井暁, 川口秀夫, 近藤昭彦, バイオマスからの微生物によるバイオモノマー生産, ケミカルエンジニヤリング, Vol.59, No.7, 22-31 (2014/07)
  4. 寺村浩, 延田紘治, 川口秀夫, 荻野千秋, 西野孝, 近藤昭彦, 植物の機能解明と新たな機能材料創出の可能性, バイオインダストリー, Vol.31, No.4, 62-68 (2014/04)
  5. 川口秀夫, 地下微生物圏へのアプローチ：石油と微生物の関わり, 生物工学会誌, 85(12): 550 (2007/12)
  6. 川口秀夫, 湯川英明, バイオ法水素生産の新展開, Ceramics Japan, 41: 312 (2006/04)
  7. Kawaguchi, H., Yukawa, H. (2006) H2 production from formic acid using an innovative bioprocess, The Journal of Fuel Cell Technology, 5(4): 83-85
  8. 川口秀夫, 湯川英明, バイオ水素研究の展開, 電気評論, 91(10): 62-63 (2006)
  9. 川口秀夫, 湯川英明, Ⅱ．生物工学技術の実際, 「バイオマス資源からのエタノール生産」, 監修：社会法人 日本生物工学会 塩谷捨明 (編集), 『生物工学ハンドブック』, ㈱コロナ社, 東京, pp.220-225 (2005/06)
  10. 川口秀夫, 湯川英明, 第1章 エコエタノール, 「6. RITEバイオプロセスによるエタノール製造」, 監修：植田充美, 近藤昭彦, 『エコバイオエネルギーの最前線：ゼロエミッション型社会を目指して』, ㈱シーエムシー出版, 東京, pp.60-67 (2005/09)
  11. 川口秀夫, 湯川英明, 「バイオ水素法の新展開」, 監修：湯川英明, 『CO2固定化・削減・有効利用の最新技術：地球温暖化対策関連技術』, ㈱シーエムシー出版, 東京, pp.220-225 (2004/08)
  12. Ike, A., Kawaguchi, H., Hirata, K., Miyamoto, K. (2001) Hydrogen photoproduction from starch in algal biomass, in Miyake, J. (ed.), Biohydrogen II, Pergamon Press, Amsterdam, pp. 53-61