TOP メンバー(先端バイオ) 川口 秀夫
経歴
- 1997/03
- 東京薬科大学 薬学部衛生薬学科 卒業
- 1999/03
- 大阪大学 大学院薬学研究科環境生物薬学専攻 博士前期課程 修了
- 2002/03
- 大阪大学 大学院薬学研究科生命情報環境科学専攻 博士後期課程 修了 博士(薬学)
- 2002/04
- 地球環境産業技術研究機構 研究員
- 2007/04
- 東京大学 大学院工学系研究科 システム創成学専攻 特任助教
- 2012/10
- 神戸大学 大学院工学研究科 応用化学専攻 特命助教
- 2016/04
- 神戸大学 大学院科学技術イノベーション研究科 特命准教授
- 2017/06
- 高機能遺伝子デザイン技術研究組合 研究員
- 2017/12
- 神戸大学 大学院科学技術イノベーション研究科 特命准教授
- 2018/07
- 神戸大学 先端バイオ工学研究センター 特命准教授
受賞等
- 2022/10 令和4年度学長表彰(財務貢献者)
- 2021/10 令和3年度学長表彰(財務貢献者)
- 2020/10 令和2年度学長表彰(財務貢献者)
- 2019/10 令和元年度学長表彰(財務貢献者)
- 2013/08 Ghent Biobased Economy Belgium, 英国王立化学協会出版(RSC Publishing)最優秀ポスター賞
Green Chemistry Poster Prize, Ghent Biobased Economy Belgium
発表論文
- Niimi-Nakamura, S., Kawaguchi, H., Uematsu, K., Teramura, H., Tsuruta, S., Kashiwagi, N., Sugai, Y., Katsuyama, Y., Ohnishi, Y., Ogino, C., Kondo, A. (2022/07) 3-Amino-4-hydroxybenzoic acid production from glucose and/or xylose via recombinant Streptomyces lividans, The Journal of General and Applied Microbiology, 68(2), 109-116
- Kawaguchi, H., Takada, K., Elkasaby, T., Pangestu, R., Toyoshima, M., Kahar, P., Ogino, C., Kaneko, T., Kondo, A. (2022/01) Recent advances in lignocellulosic biomass white biotechnology for bioplastics, Bioresource Technology, 344(B): 126165
- Kawaguchi, H., Hasunuma, T., Ohnishi, Y., Sazuka, T., Kondo, A., Ogino, C. (2021/12) Enhanced production of γ-amino acid 3-amino-4-hydroxybenzoic acid by recombinant Corynebacterium glutamicum under oxygen limitation, Microbial Cell Factories, 20: 228
- Sakuragawa, T., Wakai, S., Zhang, S., Kawaguchi, H., Ogino, C., Kondo, A. (2021/08) Accelerated glucose metabolism in hyphae-dispersed Aspergillus oryzae is suitable for biological production, Journal of Bioscience and Bioengineering, 132(2), 140-147
- Wolf, S, Becker, J., Tsuge, Y., Kawaguchi, H., Kondo, A., Marienhagen, J., Bott, M., Wendisch, V.F., Wittmann, C. (Review) (2021/06) Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being, Essays in Biochemistry, 65(2): 197–212
- Kaffashsaie, E., Yousefi, H., Nishino, T., Matsumoto, T., Mashkour, M., Madhoushi, M., Kawaguchi, H. (2021/06) Direct conversion of raw wood to TEMPO-oxidized cellulose nanofibers, Carbohydrate polymers, 262(15): 117938
- Hashimoto, S., Wake, T., Nakamura, H., Minamiyama, M., Araki-Nakamura, S., Ohmae-Shinohara, K., Koketsu, E., Okamura, S., Miura, K., Kawaguchi, H., Kasuga, S., Sazuka, T. (2021/02) The dominance model for heterosis explains culm length genetics in a hybrid sorghum variety, Scietific Reports, 11(1): 4532
- Nag, A., Ali, MA., Kawaguchi, H., Saito, S., Kawasaki, Y., Miyazaki, S., Kawamoto, H., Nugroho Adi, DT., Yoshihara, K., Masuo, S., Katsuyama, Y., Kondo, A., Ogino, C., Takaya, N., Kaneko, T.*, Ohnishi, Y. (2021/01) Ultrahigh thermoresistant lightweight bioplastics developed from fermentation products of cellulosic feedstock, Advanced Sustainable Systems, 5(1), 2000193
- Kawaguchi, H., Sazuka, T., Kondo, A. (2020/08) Complete and draft genome sequences of amino acid-producing Corynebacterium glutamicum strains ATCC 21799 and ATCC 31831 and their genomic islands, Microbiology Resource Announcements, 9(32), e00430-20
- Kobayashi, S., Kawaguchi, H., Shirai, T., Ninomiya, K., Takahashi, K., Kondo, A., Tsuge, Y. (2020/03) Automatic redirection of carbon flux between glycolysis and pentose phosphate pathway using an oxygen-responsive metabolic switch in Corynebacterium glutamicum, ACS Synthetic Biology, 9, 814-826
- Kawaguchi, H., Miyagawa, H., Nakamura-Tsuruta, S., Takaya, N., Ogino, C., Kondo, A. (2019/06) Enhanced phenyllactic acid production in Escherichia coli via oxygen limitation and shikimate pathway gene expression. Biotechnology Journal, 14(6): 1800478
- Wijaya, H., Sasaki, K., Kahar, P., Yopi, Kawaguchi, H., Sazuka, T., Ogino, C., Prasetya, B., Kondo, A. (2018/10) Repeated ethanol fermentation from membrane-concentrated sweet sorghum juice using the flocculating yeast Saccharomyces cerevisiae F118 strain, Bioresource Technology, 265, 542-547
- Tsuge, Y., Kawaguchi, H., Yamamoto, S., Nishigami, Y., Sota, M., Ogino, C., Kondo, A. (2018/07) Metabolic engineering of Corynebacterium glutamicum for production of sunscreen shinorine, Bioscience, Biotechnology, and Biochemistry, 82(7): 1252-1259 (7月号表紙採用)
- Tominaga, D., Kawaguchi, H., Hori, Y., Hasunuma, T., Ogino, C., Aburatani, S. (2018/05) Mathematical model for small size time series data of bacterial secondary metabolic pathways, Bioinformatics and Biology Insights, 12: 1-7
- Kawaguchi, H., Yoshihara, K., Hara, K.Y., Hasunuma, T., Ogino, C., Kondo, A. (2018/05) Metabolome analysis-based design and engineering of a metabolic pathway in Corynebacterium glutamicum to match rates of simultaneous utilization of D-glucose and L-arabinose, Microbial Cell Factories, 17: 76
- Teramura, H., Sasaki, K., Oshima, T., Kawaguchi, H., Ogino, C., Sazuka, T., Kondo, A. (2018/03) Effective usage of sorghum bagasse: optimization of organosolv pretreatment using 25% 1-butanol and subsequent nanofiltration membrane separation, Bioresource Technology, 252, 157-164
- Kawaguchi, H., Ogino, C., Kondo, A. (2017/12) Microbial conversion of biomass into bio-based polymers, Bioresource Technology, 245(Part B), 1664-1673
- Sasaki, K., Tsuge, Y., Kawaguchi, H., Yasukawa, M., Sasaki, D., Sazuka, T., Kamio, E., Ogino, C., Matsuyama, H., Kondo, A. (2017/08) Sucrose purification and repeated ethanol production from sugars remaining in sweet sorghum juice subjected to a membrane separation process, Applied Microbiology and Biotechnology, 101(15): 6007-6014
- Teramura, H., Sasaki, K., Kawaguchi, H., Matsuda, F., Kikuchi, J., Shirai, T., Sazuka, T., Yamasaki, Y., Takumi, S., Ogino, C., Kondo, A. (2017/08) Differences in glucose yield of residues from among varieties of rice, wheat, and sorghum after dilute acid pretreatment, Bioscience Biotechnology and Biochemistry, 81(8), 1650-1656
- Kawaguchi, H., Katsuyama, Y., Danyao, D., P. Kahar, Nakamura-Tsuruta, S., Teramura, H., Wakai, K., Yoshihara K., Minami, H., Ogino, C., Ohnishi, Y., Kondo, A. (2017/07) Caffeic acid production by simultaneous saccharification and fermentation of kraft pulp using recombinant Escherichia coli, Appl Microbiol Biotechnoliol, 101(13), 5279–5290
- Kawaguchi, H., Hasunuma, T., Ogino, C., Kondo, A. (Review) (2016/12) Bioprocessing of bio-based chemicals produced from lignocellulosic feedstocks, Current Opinion in Biotechnology, 42: 30-39
- Teramura, H., Sasaki, K., Oshima, T., Matsuda, F., Okamoto, M., Shirai, T., Kawaguchi, H., Ogino, C., Hirano, K., Sazuka, T., Kitano, H., Kikuchi, J., Kondo, A. (2016/12) Organosolv pretreatment of sorghum bagasse using a low concentration of hydrophobic solvents such as 1-butanol or 1-pentanol, Biotechnology for Biofuels, 9: 27
- Goda, T., Teramura, H., Suehiro, M., Kanamaru, K., Kawaguchi, H., Ogino, C., Kondo, A., Yamasaki, M. (2016/05) Natural variation in the glucose content of dilute sulfuric acid–pretreated rice straw liquid hydrolysates: implications for bioethanol production, Bioscience, Biotechnology, and Biochemistry, 80(5), 863-869
- Tsuge, Y., Kudou, M., Kawaguchi, H., Ishii, J., Hasunuma, T., Kondo, A. (2016/03) FudC, a protein primarily responsible for furfural detoxification in Corynebacterium glutamicum, Applied Microbiology and Biotechnology, 100(6), 2685-2692
- Nobuta, K., Teramura, H., Ito, H., Hongo, C., Kawaguchi, H., Ogino, C., Kondo, A., Nishino, T. (2016/02) Characterization of cellulose nanofiber sheets from different refining processes, Cellulose, 23(1), 403-414
- Tsuge, Y., Kawaguchi, H., Sasaki, K., Kondo, A. (Review) (2016/01) Engineering cell factories for producing building block chemicals for bio-polymer synthesis, Microbial Cell Factories, 15, 19
- Sasaki, K., Hara, K.Y., Kawaguchi, H., Sazuka, T., Ogino, C., Kondo, A. (2016/01) Nanofiltration concentration of extracellular glutathione produced by engineered Saccharomyces cerevisiae, Journal of Bioscience and Bioengineering, 121(1), 96-100
- Kawaguchi, H., Sasaki, K., Uematsu, K., Tsuge, Y., Teramura, H., Okai, N., Nakamura-Tsuruta, S., Katsuyama, Y., Sugai, Y., Ohnishi, Y., Hirano, K., Sazuka, T., Ogino, C., Kondo, A. (2015/12) 3-Amino-4-hydroxybenzoic acid production from sweet sorghum juice by recombinant Corynebacterium glutamicum, Bioresource Technology, 198: 410-417
- Sasaki, K., Okamoto, M., Shirai, T., Tsuge, Y., Teramura, H., Sasaki, D., Kawaguchi, H., Hasunuma, T., Ogino, C., Matsuda, F., Kikuchi, J., Kondo, A. (2015/06) Precipitate obtained following membrane separation of hydrothermally pretreated rice straw liquid revealed by 2D NMR to have high lignin content, Biotechnology for Biofuels, 8: 88
- Teramura, H., Sasaki, K., Oshima, T., Aikawa, S., Matsuda, F., Okamoto, M., Shirai, T., Kawaguchi, H., Ogino, C., Yamasaki, M., Kikuchi, J., Kondo, A. (2015/06) Changes in lignin and polysaccharide components in 13 cultivars of rice straw following dilute acid pretreatment as studied by solution-state 2D 1 H-13 C NMR, PLOS ONE, 10(6), e0128417
- Sasaki, K., Tsuge, Y., Sasaki, D., Kawaguchi, H., Sazuka, T., Ogino, C., Kondo, A. (2015/06) Repeated ethanol production from sweet sorghum juice concentrated by membrane separation, Bioresource Technology, 186: 351-355
- Kawaguchi, H., Teramura, H., Uematsu, K., Hara, K.Y., Hasunuma, T., Hirano, K., Sazuka, T., Kitano, H., Tsuge, Y., Kahar, P., Niimi-Nakamura, S., Oinuma, K., Takaya, N., Kasuga, S., Ogino, C., Kondo, A. (2015/04) Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse, Bioresource Technology, 182: 169-178
- Sasaki, K., Tsuge, Y., Sasaki, D., Teramura, H., Wakai, S., Kawaguchi, H., Suzuka, T., Ogino, C., Kondo, A. (2014/10) Increased ethanol production from sweet sorghum juice concentrated by a membrane separation process, Bioresource Technology, 169: 821-825
- Kawaguchi, H., Uematsu, K., Ogino, C., Teramura, H., Niimi-Nakamura, S., Tsuge, Y., Hasunuma, T., Oinuma, K., Takaya, N., Kondo, A. (2014/07) Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production, Biochemical Engineering Journal, 88: 188-194
- Tsuge, Y., Kawaguchi, H., Sasaki, K., Tanaka, T., Kondo, A. (2014/06) Two-step production of D-lactate from mixed sugars by growing and resting cells of metabolically engineered Lactobacillus plantarum, Applied Microbiology and Biotechnology, 98(11): 4911-4918
- Hara, M., Onaka, Y., Kobayashi, H., Fu, Q., Kawaguchi, H., Vilcaez, J., Sato, K. (2013/12) Mechanism of electromethanogenic reduction of CO2 by a thermophilic methanogen, Energy Proced., 37: 7021-7028
- Kuramochi, Y., Fu, Q., Kobayashi, H., Ikarashi, M., Wakayama, T., Kawaguchi, H., Vilcaez, J., Maeda, H., Sato, K. (2013/12) Electromethanogenic CO2 conversion by subsurface-reservoir microorganisms, Energy Proced, 37: 7014-7020
- Fu, Q., Kobayashi, H., Kawaguchi, H., Vilcaez, J., Sato, K. (2013/12) Identification of new microbial mediators for electromethanogenic reduction of geologically-stored carbon dioxide, Energy Proced, 37: 7006-7013
- Fu, Q., Kobayashi, H., Kawaguchi, H., Wakayama, T., Maeda, H., Sato, K. (2013/11) A thermophilic Gram-negative nitrate-reducing bacterium, Calditerrivibrio nitroreducens, exhibiting electricity generation capability, Environ Sci Technol., 47(21): 12583−12590
- Fu, Q., Kobayashi, H., Kawaguchi, H., Vilcaez, J., Wakayama, T., Maeda H., Sato, K. (2013/03) Electrochemical and phylogenetic analyses of current-generating microorganisms in a thermophilic microbial fuel cell, J Biosci Bioeng., 115(3): 268-271
- Sato, K., Kawaguchi, H., Kobayashi, H. (2013/02) Bio-electrochemical conversion of carbon dioxide to methane in geological storage reservoirs, Energy Convers Manage, 66: 343-350
- Kobayashi, H., Saito, N., Fu, Q., Kawaguchi, H., Vilcaez, J., Wakayama, T., Maeda, H., Sato, K. (2013/01) Bio-electrochemical property and phylogenetic diversity of microbial communities associated with bioelectrodes of an electromethanogenic reactor, J Biosci Bioeng., 16(1): 114-117
- Kawaguchi, H., Li, Z., Masuda, Y., Sato, K., Nakagawa, H. (2012/11) Dissolved organic compounds in reused process water for steam-assisted gravity drainage oil sands extraction, Water Res., 46: 5566-5574
- Kawaguchi, H., Kobayashi, H., Sato, K. (2012/03) Metabolic engineering of hydrophilic Rhodococcus opacus for biodesulfurization in oil-water biphasic reaction mixtures, J Biosci Bioeng., 113: 360-366
- Kobayashi, H., Endo, K., Sakata, S., Mayumi, D., Kawaguchi, H., Ikarashi, M., Miyagawa, Y., Maeda, H., Sato, K. (2012/02) Phylogenetic diversity of microbial communities associated with the crude-oil, large-insoluble-particle and formation-water components of the reservoir fluid from a non-flooded high-temperature petroleum reservoir J Biosci Bioeng., 113: 204-210
- Kobayashi, H., Kawaguchi, H., Endo, K., Mayumi, D., Sakata, S., Ikarashi, M., Miyagawa, Y., Maeda, H., Sato, K. (2012/01) Analysis of methane production by microorganisms indigenous to a depleted oil reservoir for application in microbial enhanced oil recovery, J Biosci Bioeng., 113: 84-87
- Kawaguchi, H., Sakuma, T., Nakata, Y., Kobayashi, H., Endo, K., and Sato, K. (2010/07) Methane production by Methanothermobacter thermautotrophicus to recover energy from carbon dioxide sequestered in geological reservoirs, J Biosci Bioeng., 110: 106-108
- Sasaki, M., Jojima, T., Kawaguchi, H., Inui, M., Yukawa, H. (2009/11) Engineering of pentose transport in Corynebacterium glutamicum to improve simultaneous utilization of mixed sugars, Appl Microbiol Biotechnol., 85: 105-115
- Kawaguchi, H., Sasaki, M., Vertès, A.A., Inui, M., Yukawa, H. (2009/06) Identification and functional analysis of the gene cluster for L-arabinose utilization in Corynebacterium glutamicum, Appl Environ Microbiol., 75: 3419–3429
- Kawaguchi, H., Sasaki, M., Vertès, A.A., Inui, M., Yukawa, H. (2008/01) Engineering of an L-arabinose metabolic pathway in Corynebacterium glutamicum, Appl Microbiol Biotechnol., 77: 1053-1062
- Sakai, S., Tsuchida, Y., Okino, S., Ichihashi, O., Kawaguchi, H,, Watanabe, T., Inui, M., Yukawa, H. (2007/04) Effect of lignocellulose-derived inhibitors on growth and ethanol production by growth-arrested Corynebacterium glutamicum R, Appl Environ Microbiol., 73: 2349-2353
- Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., Yukawa, H. (2007/03) Efficient induction of formate hydrogen lyase of aerobically grown Escherichia coli in a three-step biohydrogen production process, Appl Microbiol Biotechnol., 74: 754-760
- Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., Yukawa, H. (2006/11) Enhanced hydrogen production from glucose using ldh- and frd-inactivated Escherichia coli strains, Appl Microbiol Biotechnol., 73: 67-72
- Kawaguchi, H., Vertès, A.A., Okino, S., Inui, M., Yukawa, H. (2006/05) Engineering of a xylose metabolic pathway in Corynebacterium glutamicum, Appl Environ Microbiol., 72: 3418-3428
- Yoshida, A., Nishimura, T., Kawaguchi, H., Inui, M., Yukawa, H. (2005/11) Enhanced hydrogen production from formic acid by formate hydrogen lyase-overexpressing Escherichia coli strains, Appl Environ Microbiol., 71: 6762-6768
- Inui, M., Kawaguchi, H., Murakami, S., Vertès, A.A., Yukawa, H. (2004) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions, J Mol Microbiol Biotechnol., 8: 243-254
- Inui, M., Murakami, S., Okino, S., Kawaguchi, H., Vertès, A.A., Yukawa, H. (2004/09) Metabolic analysis of Corynebacterium glutamicum during lactate and succinate productions under oxygen deprivation conditions, J Mol Microbiol Biotechnol., 7: 182-196
- Kawaguchi, H., Nagase, H., Kimata, S., Doi, M., Hirata, K., Miyamoto, K. (2002/07) Effect of algal extract on H2 production by a photosynthetic bacterium Rhodobium marinum A-501: Analysis of stimulating effect by a kinetic model, J Biosci Bioeng., 94: 62-69
- Kawaguchi, H., Hashimoto, K., Hirata, K., Miyamoto, K. (2001) H2 production from algal biomass by a mixed culture of Rhodobium marinum A-501 and Lactobacillus amylovorus, J Biosci Bioeng., 91: 277-282
- Ike, A., Murakawa, T., Kawaguchi, H., Hirata, K., Miyamoto, K. (1999) Photoproduction of hydrogen from raw starch using a halophilic bacterial community, J Biosci Bioeng., 88: 72-77
総説・解説等
- 川口秀夫, 近藤昭彦, リグノセルロース系バイオマスからのバイオモノマー発酵生産, ケミカルエンジニヤリング, Vol.62, No.3, 13-20 (2017/03)
- 荻野千秋, 川口秀夫, 近藤昭彦, スーパーバイオマス, 第6章, バイオリファイナリー, 慶応義塾大学出版会, 87-104 (2016/02)
- 荻野千秋, 中村聡子, 岡井直子, 若井暁, 川口秀夫, 近藤昭彦, バイオマスからの微生物によるバイオモノマー生産, ケミカルエンジニヤリング, Vol.59, No.7, 22-31 (2014/07)
- 寺村浩, 延田紘治, 川口秀夫, 荻野千秋, 西野孝, 近藤昭彦, 植物の機能解明と新たな機能材料創出の可能性, バイオインダストリー, Vol.31, No.4, 62-68 (2014/04)
- 川口秀夫, 地下微生物圏へのアプローチ:石油と微生物の関わり, 生物工学会誌, 85(12): 550 (2007/12)
- 川口秀夫, 湯川英明, バイオ法水素生産の新展開, Ceramics Japan, 41: 312 (2006/04)
- Kawaguchi, H., Yukawa, H. (2006) H2 production from formic acid using an innovative bioprocess, The Journal of Fuel Cell Technology, 5(4): 83-85
- 川口秀夫, 湯川英明, バイオ水素研究の展開, 電気評論, 91(10): 62-63 (2006)
- 川口秀夫, 湯川英明, Ⅱ.生物工学技術の実際, 「バイオマス資源からのエタノール生産」, 監修:社会法人 日本生物工学会 塩谷捨明 (編集), 『生物工学ハンドブック』, ㈱コロナ社, 東京, pp.220-225 (2005/06)
- 川口秀夫, 湯川英明, 第1章 エコエタノール, 「6. RITEバイオプロセスによるエタノール製造」, 監修:植田充美, 近藤昭彦, 『エコバイオエネルギーの最前線:ゼロエミッション型社会を目指して』, ㈱シーエムシー出版, 東京, pp.60-67 (2005/09)
- 川口秀夫, 湯川英明, 「バイオ水素法の新展開」, 監修:湯川英明, 『CO2固定化・削減・有効利用の最新技術:地球温暖化対策関連技術』, ㈱シーエムシー出版, 東京, pp.220-225 (2004/08)
- Ike, A., Kawaguchi, H., Hirata, K., Miyamoto, K. (2001) Hydrogen photoproduction from starch in algal biomass, in Miyake, J. (ed.), Biohydrogen II, Pergamon Press, Amsterdam, pp. 53-61