Members

BioProduction Engineering Lab Members (Eng. Biol. Res. C) Kentaro Noi

Assistant ProfessorKentaro Noi

Education and Experience

2005/03
Bachelor of Engineering, Tottori University
2010/03
Doctor of Medical science, Tottori University
2010/04
Research Fellow (GCOE), Kumamoto University
2012/04
Postdoctoral Fellow, Kumamoto University
2013/04
Postdoctoral Fellow, Osaka University
2014/04
Postdoctoral Fellow, Kumamoto University
2017/04
Specially Appointed Assistant Professor, Osaka University
2022/04
Assistant Professor, Institute of Engineering, Tokyo University of Agriculture and Technology
2024/05
Assistant Professor, Engineering Biology Research Center, Kobe University

Awards

  • 2022/06　Young Scientist Award, The 23nd Annual Meeting of the Protein Science Society of Japan
  • 2017/10　Young Scientist Award, The 35th Symposium on Ultrasonic Electronics (USE2017)
  • 2015/11　Academic Encouragement Award, Higo Medical Education Promotion Association
    (Public Interest Incorporated Foundation)
  • 2011/11　Poster Award, Symposium on Protein Community
  • 2011/11　Poster Award, 9th International Conference on AAA Proteins

Publications

  1. Takatsu, M., Morihiro, K., Watanabe, H., Yuki, M., Hattori, Noi, K., Aikawa, K., Noguchi, K., Yohda, M., Okazoe, T., Okamoto, A. (2023/11) Cellular Penetration and Intracellular Dynamics of Perfluorocarbon-Conjugated DNA/RNA as a Potential Means of Conditional Nucleic Acid Delivery, ACS Chemical Biology, 18(12), 2590-2598
  2. Cai, X., Ito, S., Noi, K., Kato, Y., Nagata, K., Inaba, K. (2023/11) Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP, The Journal of Biochemistry, 299(11), 105274
  3. Noi, K., Nakajima, K., Yamaguchi, K., So, M., Ikenaka, K., Mochizuki, H., Goto, Y., Ogi, H. (2022/03) Acceleration of amyloid fibril formation by multichannel sonochemical reactor, Japanese Journal of Applied Physics, 61, SG1002
  4. Noi, K., Ikenaka, K., Mochizuki, H., Goto, Y., Ogi, H. (2021/08) Disaggregation behavior of amyloid β fibrils by anthocyanins studied by total-internal-reflection-fluorescence microscopy coupled with a wireless quartz-crystal microbalance biosensor, Analytical Chemisyry, 93(32), 11176-11183
  5. Inoue, Y., Hanazono, Y., Noi, K., Kawamot, A., Kimatsuka, M., Harada, R., Takeda, K., Kita, R., Iwamasa, N., Shibata, K., Noguchi, K., Shigeta, Y., Namba, K., Ogura, T., Miki, K., Shinohara, K., Yohda, M. (2021/07) Split conformation of Chaetomium thermophilum Hsp104 disaggregase, Structure, 29(7), 721-730
  6. Saito, T., Matunaga, D., Matsui, TS., Noi, K., Deguchi, S. (2021/07) Determining the domain-level reaction-diffusion properties of an actin-binding protein transgelin-2 within cells, Experimental Cell Research, 404, 112619
  7. Nakajima, K., Noi, K., Yamaguchi, K., So, M., Ikenaka, K., Mochizuki, H., Ogi, H., Goto, Y. (2021/05) Optimized sonoreactor for accelerative amyloid-fibril assays through enhancement of primary nucleation and fragmentation, Ultrasonics Sonochemistry, 73, 105508
  8. Hirayama, C., Machida, K., Noi, K., Murakawa, T., Okumura, M., Ogura, T., Imataka, H., Inaba, K. (2021/04) Distinct roles and actions of protein disulfide isomerase family enzymes in catalysis of nascent-chain disulfide bond formation, iScience, 24(4), 102296
  9. Noi, K., Iijima, M., Kuroda, S., Kato, F., Ogi, H. (2020/03) Mechanism of affinity enhanced protein adsorption on bio-nanocapsules studied by viscoelasticity measurement with wireless QCM biosensor, Japanese Journal of Applied Physics, 59, KKB03
  10. Noi, K., Iijima, M., Kuroda, S., Ogi, H. (2019/08) Ultrahigh-Sensitive Wireless QCM with Bio-nanocapsules, Sensors and Actuators B: Chemical, 293, 59-62
  11. Noi, K., Iwata, A., Kato, F., Ogi, H. (2019/07) Ultrahigh-Frequency Wireless MEMS QCM Biosensor for Direct Label-Free Detection of Biomarkers in a Large Amount of Contaminants, Analytical Chemistry, 91(15), 9398-9402
  12. Yamauchi, S., Kobashigawa, Y., Fukuda, N., Teramoto, M., Toyota, Y., Liu, C., Ikeguchi, Y., Sato, T., Sato, Y., Kimura, H., Masuda, T., Ohtsuki, S., Noi, K., Ogura, T., Morioka, H. (2019/07) Cyclization of Single-Chain Fv Antibodies Markedly Suppressed Their Characteristic Aggregation Mediated by Lnter-Chain VH-VL Interactions, Molecules, 24, 2620
  13. Okumura, M., Noi, K., Kanemura, S., Kinoshita, M., Saio, T., Inoue, Y., Hikima, T., Akiyama, S., Ogura, T., Inaba, K. (2019/04) Dynamic assembly of protein disulfide isomerase in catalysis of oxidative folding, Nature Chemical Biology, 15, 499-509
  14. Kakuda, K., Ikenaka, K., Araki, K., So, M., Aguirre, C., Kajiyama, Y., Konaka, K., Noi, K., Baba, K., Tsuda, H., Nagano, S., Ohmichi, T., Nagai, Y., Tokuda, T., El-Agnaf, O.M.A., Ogi, H., Goto, Y., Mochizuki, H. (2019/04) Ultrasonication-based rapid amplification of α-synuclein aggregates in cerebrospinal fluid, Scientific Reports, 9, 6001
  15. Niwa, H., Miyauchi-Nanri, Y., Omoto, K., Mukai, S., Noi, K., Ogura, T., Fujiki, Y. (2018/12) A newly isoloated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein, The Journal of Biochemistry, 164(6), 437-447
  16. Morita, K., Yamamoto, YY., Hori, A., Obata, T., Uno, Y., Shinohara, K., Noguchi, K., Noi, K., Ogura, T., Ishii, K., Kato, K., Kikumoto, M., Arranz, R., Valouesta, J.M., Yohda, M. (2018/08) Expression, functional characterization, and preliminary crystallization of the cochaperone prefoldin from the thermophilic fungus Chaetomium thermophilum, International Journal of Molecular Sciences, 19(8), E2452
  17. Lai, Y-T., Ogi, H., Noi, K., Kato, F. (2018/04) Viscoelasticity response during fibrillation of amyloid β peptides on quartz crystal microbalance biosensor, Langmuir, 34, 5474-5479
  18. Fukuda, N., Noi, K., Weng, L., Kobashigawa, Y., Miyazaki, H., Wakeyama, Y., Takaki, M., Nakahara, Y., Tatsuno, Y., Uchida-Kamekura, M., Suwa, Y., Sato, T., Ichikawa-Tomikawa, N., Nomizu, M., Fujiwara, Y., Ohsaka, F., Saitoh, T., Maenaka, K., Kumeta, H., Shinya, S., Kojima, C., Ogura, T., Morioka, H. (2017/10) Production of Single-Chain Fv Antibodies Specific for GA-pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion, Molecules, 22(10), 1695
  19. Yamato, M., Matsuzaki, T., Araki, R., Tsuchida, S., Okuda, K., Ying, H., Sanada, S., Asanuma, H., Asano, Y., Asakura, M., Torii, H., Noi, K., Ogi, H., Iwamoto, R., Mekada, E., Takashima, S., Kitakaze, M., Sakata, Y., Minamino, T. (2017/09) RNA aptamer binds heparin-binding epidermal growth factor-like growth factor with high affinity and specificity and neutralizes its activity, International Journal of Gerontology, 11, 191-196
  20. Maegawa, K., Watanabe, S., Noi, K., Okumura, M., Amagai, Y., Inoue, M., Ushioda, R., Nagata, K., Ogura, T., Inaba, K. (2017/06) The highly dynamic　nature　of　ERdj5　is　key　to　efficient　elimination　of　aberrant　protein　oligomers　through　ER-associated degradation, Structure, 25(6), 846-857
  21. Yamamoto, D., Noi, K., Ogura, T. (2017/03) A substrate for observing histidine-tagged proteins by high-speed atomic force microscopy, Fukuoka University Science Reports, 47(1), 1-6
  22. Nakajima, K., Ogi, H., Adachi, K., Noi, K., Hirao, M., Yagi, H., Goto, Y. (2016/02) Nucleus factory on cavitation bubble for amyloid β fibril, Scientific Reports, 6, 22015
  23. Hamada, H., Ogi, H., Noi, K., Yagi, H., Goto, Y., Hirao, M. (2015/05) Nucleation-fibrillation dynamics of Aβ1-40 peptides on liquid-solid surface studied by total-internal-reflection fluorescence microscopy coupled with quartz-crystal microbalance biosensor, Japanese Journal of Applied Physics, 54, 07HE01
  24. Johjima, A., Noi, K., Nishikori, S., Ogi, H., Esaki, M., Ogura, T. (2015/05) Microtubule severing by katanin p60 AAA+ ATPase requires the C-terminal acidic tails of both α- and β-tubulins and basic amino acid residues in the AAA+ ring pore, The Journal of Biochemistry, 290(18), 11762-11770
  25. Ogi, H., Fukushima, M., Hamada, H., Noi, K., Hirao, M., Yagi, H., Goto, Y. (2014/11) Ultrafast propagation of β-amyloid fibrils in oligomeric cloud, Scientific Reports, 4, 6960
  26. Noi, K., Yamamoto, D., Nishikori, S., Arita-Morioka, K., Kato, T., Ando, T., Ogura, T. (2013/11) High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97, Structure, 21(10), 1992-2002
  27. Noi, K., Kitamura, A., Hirai, H., Hongo, K., Sakurai, T., Mizobata, T., Kawata, Y. (2012/07) Suppression of Sup35 amyloid fibril formation by group II chaperonin from Thermoplasma acidophilum, American Journal of Respiratory Cell and Molecular Biology, 2(3), 265-275
  28. Noi, K., Hirai, H., Hongo, K., Mizobata, T., Kawata, Y. (2009/10) A potentially versatile nucleotide hydrolysis activity of group II chaperonin monomers from Thermoplasma acidophilum, Biochemistry, 48(40), 9405-9415
  29. Hirai, H., Noi, K., Hongo, K., Mizobata, T., Kawata, Y. (2008/04) Functional characterization of the recombinant group II chaperonin alpha from Thermoplasma acidophilum, The Journal of Biochemistry, 143(4), 505-515

Reviews & Commentaries

  1. 野井 健太郎, 荻 博次, 無線QCM粘弾性計測によるBNC上の蛋白質捕捉時の親和性向上機構の解析, 超音波テクノ, 33(5) (2021)
  2. Okumura, M., Noi, K., Inaba, K. Visualization of structural dynamics of protein disulfide isomerase enzymes in catalysis of oxidative folding and reductive unfolding, Current Oppnion in Structural Biology, 66, 49-57 (2021)