メンバー紹介

TOP メンバー(イノベ) Christopher John Vavricka Jr.

特命助教Christopher John Vavricka Jr.

経歴

2000-2004
B.S., Virginia Tech
2005-2009
Ph.D., Virginia Tech
2009/10
中国科学院 微生物研究所 外国人特別研究員
2012/10
中国科学院 北京生命科学研究院 准教授
2014/10
岡山大学 農学部 日本学術振興会外国人特別研究員
2016/11
神戸大学大学院 科学技術イノベーション研究科 特命助教

受賞等

  • 荣获2013年度中国科学院病原微生物与免疫学重点实验室利德曼杯年度科研成就奖 (2013)
  • 《Nature Communications》杂志上的论文"Influenza Neuraminidase Operates via a Nucleophilic Mechanism and can be Targeted by Covalent Inhibitors"荣获2013 年度“泽平优秀论文 奖”(2013)
  • 中科院北京生命科学研究院科研论文奖励 (2013)
  • 中国科学院病原微生物与免疫学重点实验室周家炽病毒学论文奖 (2013)
  • GENEWIZ 金唯智论文奖 (2013)
  • 中国科学院病原微生物与免疫学重点实验室周家炽病毒学论文奖 (2011)
  • 中国科学院病原微生物与免疫学重点实验室度“强耀优秀论文奖”颁奖 (2011)
  • Most Courageous Award, Bishop Eustace High School Varsity Wrestling (2000)

発表論文

  1. Hasunuma, T.*, Matsuda, M., Kato, Y., Vavricka, CJ., Kondo, A. (2018) Temperature enhanced succinate production concurrent with increased central metabolism turnover in the cyanobacterium Synechocystis sp. PCC 6803, Metabolic Engineering, 48, 109-120
  2. Wu, YB., Wang, YZ., Ni, ZY., Qing, X., Shi, QW., Sauriol, F., Vavricka, CJ., Gu, YC., Kiyota, H. (2017) Xylomexicanins I and J: limonoids with unusual B/C rings from xylocarpus granatum. Journal of Natural Products, 80(9), 2547-2550
  3. Vavricka, CJ., Muto, C., Hasunuma, T., Kimura, Y., Araki, M., Wu, Y., Gao, GF., Ohrui, H., Izumi, M., Kiyota, H. (2017) Synthesis of sulfo-sialic acid analogues: potent neuraminidase inhibitors in regards to anomeric functionality, Scientific Reports, 7(1): 8239
  4. Qing, X., Yan, HM., Ni, ZY., Vavricka, CJ., Zhang, ML., Shi, QW., Gu, YC., Kiyota, H. (2017) Chemical and pharmacological research on the plants from genus Ajuga, Heterocyclic Communications, 23(4), 245
  5. Kato, Y., Ho, SH., Vavricka, CJ., Chang, JS., Hasunuma, T., Kondo, A. (2017) Evolutionary engineering of salt-resistant Chlamydomonas sp. strains reveals salinity stress-activated starch-to-lipid biosynthesis switching, Bioresource Technology, 245(Part B), 1484-1490
  6. Osada, T., Maeda, M., Tanabe, C., Furuta, K., Vavricka, CJ., Sasaki, E., Okano, M., Kimura, Y. (2017) Glycoform of a newly identified pollen allergen, Cha o 3, from Chamaecyparis obtusa (Japanese cypress, Hinoki). Carbohydrate Research, 448, 18-23
  7. Maeda, M., Ebara, N., Tani, M., Vavricka, CJ., Kimura, Y. (2017) Occurrence of complex type free N-glycans with a single GlcNAc residue at the reducing termini in the fresh-water plant, Egeria densa. Glycoconjugate Journal, doi: 10.1007/s10719-016-9758-z.
  8. Wu, Y., Gao, F., Qi, J., Bi, Y., Fu, L., Mohan, S., Chen, Y., Li, X., Pinto, BM., Vavricka CJ., Tien, P., Gao, GF. (2016) Resistance to Mutant Group 2 Influenza Virus Neuraminidases of an Oseltamivir-Zanamivir Hybrid Inhibitor. J Virol, 14;90(23): 10693-10700
  9. Maeda, M., Tani, M., Yoshiie, T., Vavricka, CJ., Kimura, Y. (2016) Structural features of N-glycans linked to glycoproteins expressed in three kinds of water plants: predominant occurrence of the plant complex type N-glycans bearing Lewis a epitope. Carbohydrate Research, 435, 50-57
  10. Wu, Y., Vavricka, CJ., Wu, Y., Li, Qing., Rudrawar, S., Thomson, RJ., von, Itzstein, M., Gao, GF., Qi, J. (2015) Atypical group 1 neuraminidase pH1N1-N1 bound to a group 1 inhibitor. Protein & Cell 6, 771-773
  11. Sun, X., Li, Q., Wu, Y., Wang, M., Liu, Y., Qi, J., Vavricka, CJ., Gao, GF. (2014) Structure of influenza virus N7: the last piece of the neuraminidase "jigsaw" puzzle. Journal of Virology, 88, 9197-207
  12. Abdel-Mageed, WM., Bayoumi, SA., Chen, C., Vavricka, CJ., Li, L., Malik, A., Dai, H., Song, F., Wang, L., Zhang, J., Gao, GF., Lv, Y., Liu, L., Liu, X., Sayed, HM., Zhang, L. (2014) Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity. Bioorganic & Medicinal Chemistry 22, 2236-43
  13. Vavricka, CJ., Han, Q., Mehere, PV., Christensen, BM., Li, J. (2014) Tyrosine metabolic enzymes in insects and mammals: a comparative perspective. Insect Science, doi:10.1111/1744-7917.12038
  14. Yan, W., Bi, Y., Vavricka, CJ., Sun, X., Zhang, Y., Gao, F., Yan, J., Zhao, M., Xiao, H., Qin, C., He, J., Liu, W., Yan, J., Gao, GF. (2013) Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Research (Front Cover and Top 10 Article), 23, 1347-1355
  15. Li, Q., Qi, J., Wu, Y., Kiyota, H., Tanaka, K., Suhara, Y., Ohrui, H., Suzuki, Y., Vavricka, CJ., Gao, GF. (2013) Functional and structural analysis of influenza neuraminidase N3 offers further insight into the mechanisms of oseltamivir-resistance. Journal of Virology, 87, 10016-10024
  16. Wu, Y., Qin, G., Gao, F., Liu, Y., Vavricka, CJ., Qi, J., Jiang, H., Yu, K., Gao, GF. (2013) Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding. Scientific Reports, 3, 1551
  17. Vavricka, CJ., Liu, Y., Kiyota, H., Sriwilaijaroen, N., Qi, J., Tanaka, Y., Wu, Y., Li, Q., Li, Y., Yan, J., Suzuki, Y., Gao, GF. (2013) Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors. Nature Communications, 4, 1491
  18. Li, Q., Sun, X., Li, Z., Liu, Y., Vavricka, CJ., Qi, J., Gao, GF. (2012) Structural and functional characterization of the neuraminidase-like molecule N10 derived from bat influenza A virus. Proceedings of the National Academy of Sciences 109, 18897-18902
  19. Vavricka, CJ.,, Li, Q., Wu, Y., Qi, J., Wang, M., Liu, Y., Gao, F., Liu, J., Feng, E., Wang, J., Hong, L., Jiang, H., Gao, GF. (2011) Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms of influenza NA inhibition. PLoS Pathogens, 7, e1002249
  20. Wang, M., Qi, J., Liu, Y., Vavricka, CJ., Wu, Y., Li, Q., Gao, GF. (2011) Influenza A virus neuraminidase N5 has an extended 150-Cavity. Journal of Virology 85, 8431-8435
  21. Vavricka, CJ. (2011) Adventures and lessons of an American biochemist in China. Protein & Cell, 2, 601-603
  22. Vavricka, CJ., Liu, Y., Li, Q., Shi, Y., Wu, Y., Sun, Y., Qi, J., Gao, GF. (2011) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase. Chinese Science Bulletin (Front Cover), 56, 1747-1752
  23. Sun, M., Vavricka, CJ., Zhu, B. (2011) What job can a bug give? A controversy over the arsenic-guzzling bacterium cultured by NASA. Protein & Cell, 2, 261-263
  24. Vavricka, CJ., Han, Q., Huang, Y., Erickson, SM., Harich, K., Christensen, BM., Li, J. (2011) From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects. PLoS One, 6, e16124
  25. Liu, J., Wu, P., Gao, F., Qi, J., Kawana-Tachikawa, A., Xie, J., Vavricka, CJ., Iwamoto, A., Li, T., Gao, GF. (2010) Novel immunodominant peptide presentation strategy: a featured HLA-A*2402 restricted CTL-epitope stabilized by intra-chain hydrogen-bonds from SARS-CoV nucleocapsid protein. Journal of Virology 84, 11849-11857
  26. Mehere, P., Han, Q., Lemkul, JA., Vavricka, CJ., Robinson, H., Bevan, DR., Li, J. (2010) Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations. Protein & Cell, 1, 1023-1032
  27. Li, Q., Qi, J., Zhang, W., Vavricka, CJ., Shi, Y., Wei, J., Feng, E., Shen, J., Chen, J., Di, Liu., He, J., Yan, J., Liu, Hong., Jiang, H., Maikun, M., Li, X., Gao, GF. (2010) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nature Structural and Molecular Biology, 17, 1266-1268
  28. Vavricka, CJ., Christensen, BM., Li, J. (2010) Melanization in living organisms: a perspective of species evolution. Protein & Cell (Front Cover), 1, 830-841
  29. Sun, Y., Shi, Y., Zhang, W., Li, Q., Liu, D., Vavricka, C., Yan, J., Gao, GF. (2010) In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus A (H1N1)-2009. Science China Life Sciences, 53, 633-642
  30. Zhang, W., Qi, J., Shi, Y., Qing, L., Gao, F., Sun, Y., Lu, X., Lu, Q., Vavricka, CJ., Liu, D., Yan, J., Gao, GF. (2010) Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein & Cell, 1, 459-467
  31. Vavricka, CJ., Ray, KW., Christensen, BM., Li, J. (2010) Purification and N-glycosylation analysis of melanoma antigen dopachrome tautomerase. Protein Journal, 29, 204-12
  32. Li, JS., Vavricka, CJ., Christensen, BM., Li, J. (2007) Proteomic analysis of N-glycosylation in mosquito dopachrome conversion enzyme. Proteomics, 7, 2557-2569